Microencapsulation and characterization of tramadol–resin complexes

• Published in: Journal of controlled release Vol. 66; no. 2; pp. 107 - 113
• Main Authors: Zhang, Zhi-Yan, Ping, Qi-Neng, Xiao, Bin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.05.2000; Elsevier
• Subjects: Biological and medical sciences; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems - methods; Ethylcellulose; General pharmacology; Medical sciences; Microencapsulation; Microscopy, Electron, Scanning; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Plasticizers; Polymers; Resins, Plant; Solvent systems; Solvents; Spray-drying; Sustained release; Tramadol; Tramadol–resin complexes; Viscosity; Solvent systems; Tramadol–resin complexes; Sustained release; Microencapsulation; Spray-drying; Ethylcellulose; Encapsulation; Viscosity; Pharmaceutical technology; Controlled release form; Control release polymer; Microcapsule; Spray drying; Cellulose(ethyl); Drug carrier; Complexes; Dissolution; Analgesic; Plasticizer; Formulation; Tramadol; Dosage form; Active ingredient; Ion exchange resin; Solvent; Release; Physicochemical properties; Rheological properties

Tramadol was complexed with a sulfonic acid cation-exchange resin by a column method. Microencapsulation of tramadol–resin complexes (TRC) was carried out by the spray-drying method. The effect of ethylcellulose (EC) of various viscosities, different solvent systems and addition of plasticizers on m...