Associations between Use of Antimalarial Medications and Health among U.S. Veterans of the Wars in Iraq and Afghanistan
Mefloquine (Lariam ; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the , a population-based study of U.S. veterans who served bet...
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Published in | The American journal of tropical medicine and hygiene Vol. 99; no. 3; pp. 638 - 648 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Institute of Tropical Medicine
01.01.2018
The American Society of Tropical Medicine and Hygiene |
Subjects | |
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Abstract | Mefloquine (Lariam
; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the
, a population-based study of U.S. veterans who served between 2001 and 2008, we investigated associations between self-reported use of antimalarial medications and overall physical and mental health (MH) using the twelve-item short form, and with other MH outcomes using the post-traumatic stress disorder Checklist-17 and the Patient Health Questionnaire (anxiety, major depression, and self-harm). Multivariable logistic regression was performed to examine associations between health measures and seven antimalarial drug categories: any antimalarial, mefloquine, chloroquine, doxycycline, primaquine, mefloquine plus any other antimalarial, and any other antimalarial or antimalarial combination while adjusting for the effects of deployment and combat exposure. Data from 19,487 veterans showed that although antimalarial use was generally associated with higher odds of negative health outcomes, once deployment and combat exposure were added to the multivariable models, the associations with each of the MH outcomes became attenuated. A positive trend was observed between combat exposure intensity and prevalence of the five MH outcomes. No significant associations were found between mefloquine and MH measures. These data suggest that the poor physical and MH outcomes reported in this study population are largely because of combat deployment exposure. |
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AbstractList | Mefloquine (Lariam
; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the
, a population-based study of U.S. veterans who served between 2001 and 2008, we investigated associations between self-reported use of antimalarial medications and overall physical and mental health (MH) using the twelve-item short form, and with other MH outcomes using the post-traumatic stress disorder Checklist-17 and the Patient Health Questionnaire (anxiety, major depression, and self-harm). Multivariable logistic regression was performed to examine associations between health measures and seven antimalarial drug categories: any antimalarial, mefloquine, chloroquine, doxycycline, primaquine, mefloquine plus any other antimalarial, and any other antimalarial or antimalarial combination while adjusting for the effects of deployment and combat exposure. Data from 19,487 veterans showed that although antimalarial use was generally associated with higher odds of negative health outcomes, once deployment and combat exposure were added to the multivariable models, the associations with each of the MH outcomes became attenuated. A positive trend was observed between combat exposure intensity and prevalence of the five MH outcomes. No significant associations were found between mefloquine and MH measures. These data suggest that the poor physical and MH outcomes reported in this study population are largely because of combat deployment exposure. Mefloquine (Lariam®; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the National Health Study for a New Generation of U.S. Veterans, a population-based study of U.S. veterans who served between 2001 and 2008, we investigated associations between self-reported use of antimalarial medications and overall physical and mental health (MH) using the twelve-item short form, and with other MH outcomes using the post-traumatic stress disorder Checklist-17 and the Patient Health Questionnaire (anxiety, major depression, and self-harm). Multivariable logistic regression was performed to examine associations between health measures and seven antimalarial drug categories: any antimalarial, mefloquine, chloroquine, doxycycline, primaquine, mefloquine plus any other antimalarial, and any other antimalarial or antimalarial combination while adjusting for the effects of deployment and combat exposure. Data from 19,487 veterans showed that although antimalarial use was generally associated with higher odds of negative health outcomes, once deployment and combat exposure were added to the multivariable models, the associations with each of the MH outcomes became attenuated. A positive trend was observed between combat exposure intensity and prevalence of the five MH outcomes. No significant associations were found between mefloquine and MH measures. These data suggest that the poor physical and MH outcomes reported in this study population are largely because of combat deployment exposure. Mefloquine (Lariam ® ; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the National Health Study for a New Generation of U.S. Veterans , a population-based study of U.S. veterans who served between 2001 and 2008, we investigated associations between self-reported use of antimalarial medications and overall physical and mental health (MH) using the twelve-item short form, and with other MH outcomes using the post-traumatic stress disorder Checklist-17 and the Patient Health Questionnaire (anxiety, major depression, and self-harm). Multivariable logistic regression was performed to examine associations between health measures and seven antimalarial drug categories: any antimalarial, mefloquine, chloroquine, doxycycline, primaquine, mefloquine plus any other antimalarial, and any other antimalarial or antimalarial combination while adjusting for the effects of deployment and combat exposure. Data from 19,487 veterans showed that although antimalarial use was generally associated with higher odds of negative health outcomes, once deployment and combat exposure were added to the multivariable models, the associations with each of the MH outcomes became attenuated. A positive trend was observed between combat exposure intensity and prevalence of the five MH outcomes. No significant associations were found between mefloquine and MH measures. These data suggest that the poor physical and MH outcomes reported in this study population are largely because of combat deployment exposure. Mefloquine (Lariam ® ; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may have used mefloquine during recent Southwest Asia deployments. Using data from the National Health Study for a New Generation of U.S. Veterans , a population-based study of U.S. veterans who served between 2001 and 2008, we investigated associations between self-reported use of antimalarial medications and overall physical and mental health (MH) using the twelve-item short form, and with other MH outcomes using the post-traumatic stress disorder Checklist-17 and the Patient Health Questionnaire (anxiety, major depression, and self-harm). Multivariable logistic regression was performed to examine associations between health measures and seven antimalarial drug categories: any antimalarial, mefloquine, chloroquine, doxycycline, primaquine, mefloquine plus any other antimalarial, and any other antimalarial or antimalarial combination while adjusting for the effects of deployment and combat exposure. Data from 19,487 veterans showed that although antimalarial use was generally associated with higher odds of negative health outcomes, once deployment and combat exposure were added to the multivariable models, the associations with each of the MH outcomes became attenuated. A positive trend was observed between combat exposure intensity and prevalence of the five MH outcomes. No significant associations were found between mefloquine and MH measures. These data suggest that the poor physical and MH outcomes reported in this study population are largely because of combat deployment exposure. |
Author | Cypel, Yasmin S Dursa, Erin K Bossarte, Robert M Schneiderman, Aaron I |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors’ addresses: Aaron I. Schneiderman, Yasmin S. Cypel, and Erin K. Dursa, Department of Veterans Affairs, Epidemiology Program, Post Deployment Health Services (10P4Q), Office of Patient Care Services, Veterans Health Administration, Washington, DC, E-mails: aaron.schneiderman@va.gov, yasmin.cypel@va.gov, and erin.dursa2@va.gov. Robert Bossarte, Department of Behavioral Medicine and Psychiatry, West Virginia University Injury Control Research Center, West Virginia University School of Medicine, Morgantown, WV, E-mail: rbossarte@hsc.wvu.edu. |
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References | Ware (b49) 1996; 34 Grabias (b46) 2016; 15 Wells (b63) 2006; 74 Schlagenhauf (b27) 2003; 327 Dursa (b37) 2014; 27 SAS Institute Inc (b53) 2014 Brisson (b7) 2012; 86 Lobel (b64) 1993; 341 Cronbach (b48) 1951; 16 Costedoat-Chalumeau (b21) 2015; 49 Baird (b68) 2001; 33 Hill (b24) 2006; 75 Weinke (b25) 1991; 45 Spitzer (b52) 1999; 282 Taylor (b5) 2004; 27 Weathers (b50) 1993 Ollivier (b60) 2004; 98 Department of Veterans Affairs, Epidemiology Program, Post-Deployment Health Group (b8) 2017 Peterson (b43) 2011; 2011 Lee (b39) 2015; 180 Van Riemsdijk (b57) 1997; 52 Ringqvist (b30) 2015; 13 Eber (b41) 2013; 178 Fukuda (b6) 2017 Stürchler (b26) 1990; 322 Lee (b17) 2013; 43 Pagès (b16) 2002; 7 Jaspers (b61) 1996; 55 Tan (b34) 2017; 17 Nevin (b40) 2010; 19 Toovey (b28) 2009; 7 Korhonen (b3) 2007; 33 Seal (b38) 2009; 99 Schlagenhauf (b59) 2009; 16 Department of Defense (DoD) (b47) 2003 Armed Forces Epidemiological Board (b11) 2003 Office of the Assistant Secretary of Defense for Health Affairs (b9) 2009 Javorsky (b44) 2001; 13 Van Riemsdijk (b31) 2002; 58 Tan (b13) 2011; 84 Alkadi (b4) 2007; 53 Melles (b19) 2015; 122 Office of the Assistant Secretary of Defense for Health Affairs (b10) 2013 Van Riemsdijk (b32) 2002; 72 Sonmez (b15) 2005; 51 Keen (b51) 2008; 45 Boudreau (b45) 1993; 44 Food and Drug Administration (b35) 2013 Schneider (b62) 2013; 11 Ebringer (b66) 2011; 105 Schlagenhauf (b58) 1996; 1 Jong (b20) 2001; 8 Braga (b22) 2015; 2015 Kolifarhood (b65) 2017; 17 Dillman (b42) 2014 McArdle (b36) 2005; 49 Schwartz (b67) 1999; 29 Barrett (b56) 1996; 313 Saunders (b14) 2015; 93 Van Riemsdijk (b33) 2005; 66 Chen (b1) 2007; 297 Sloan (b18) 2008; 7 Yoon (b54) 2013 Nevin (b69) 2016; 15 Tickell-Painter (b2) 2017; 20 Armed Forces Epidemiological Board (b12) 2004 Eick-Cost (b29) 2017; 96 Ashley (b23) 2014; 13 Kuha (b55) 1997 |
References_xml | – volume: 43 start-page: 919 year: 2013 ident: b17 article-title: Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in Australians deployed abroad contributor: fullname: Lee – volume: 66 start-page: 199 year: 2005 ident: b33 article-title: Mefloquine increases the risk of serious psychiatric events during travel abroad: a nationwide case-control study in the Netherlands contributor: fullname: Van Riemsdijk – volume: 45 start-page: 465 year: 2008 ident: b51 article-title: Psychometric properties of PTSD checklist in sample of male veterans contributor: fullname: Keen – volume: 322 start-page: 1752 year: 1990 ident: b26 article-title: Neuropsychiatric side effects of mefloquine contributor: fullname: Stürchler – volume: 122 start-page: 110 year: 2015 ident: b19 article-title: Pericentral retinopathy and racial differences in hydroxychloroquine toxicity contributor: fullname: Melles – volume: 84 start-page: 517 year: 2011 ident: b13 article-title: Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis contributor: fullname: Tan – volume: 72 start-page: 294 year: 2002 ident: b32 article-title: Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: a focus on neuropsychiatric adverse events contributor: fullname: Van Riemsdijk – year: 1993 ident: b50 contributor: fullname: Weathers – volume: 7 start-page: 919 year: 2002 ident: b16 article-title: Tolerability of doxycycline monohydrate salt vs. chloroquine-proguanil in malaria chemoprophylaxis contributor: fullname: Pagès – volume: 58 start-page: 441 year: 2002 ident: b31 article-title: Neuropsychiatric events during prophylactic use of mefloquine before travelling contributor: fullname: Van Riemsdijk – year: 2004 ident: b12 contributor: fullname: Armed Forces Epidemiological Board – volume: 98 start-page: 639 year: 2004 ident: b60 article-title: The relationship between body weight and tolerance to mefloquine prophylaxis in non-immune adults: results of a questionnaire-based study contributor: fullname: Ollivier – volume: 341 start-page: 848 year: 1993 ident: b64 article-title: Long-term malaria prophylaxis with weekly mefloquine contributor: fullname: Lobel – volume: 17 start-page: 5 year: 2017 ident: b65 article-title: Prophylactic efficacy of primaquine for preventing Plasmodium falciparum and Plasmodium vivax parasitaemia in travelers: a meta-analysis and systematic review contributor: fullname: Kolifarhood – volume: 327 start-page: 1078 year: 2003 ident: b27 article-title: Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study contributor: fullname: Schlagenhauf – year: 2003 ident: b47 contributor: fullname: Department of Defense (DoD) – volume: 7 start-page: 2 year: 2009 ident: b28 article-title: Mefloquine toxicity: a literature review contributor: fullname: Toovey – volume: 17 start-page: 50 year: 2017 ident: b34 article-title: Long term health outcomes among returned Peace Corps volunteers after malaria prophylaxis, 1995–2014 contributor: fullname: Tan – year: 2014 ident: b53 contributor: fullname: SAS Institute Inc – volume: 33 start-page: 1990 year: 2001 ident: b68 article-title: Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia contributor: fullname: Baird – volume: 20 start-page: 5 year: 2017 ident: b2 article-title: Deaths and parasuicides associated with mefloquine chemoprophylaxis: a systematic review contributor: fullname: Tickell-Painter – volume: 13 start-page: 302 year: 2001 ident: b44 article-title: Cognitive and neuropsychiatric side effects of mefloquine contributor: fullname: Javorsky – volume: 45 start-page: 86 year: 1991 ident: b25 article-title: Neuropsychiatric side effects after the use of mefloquine contributor: fullname: Weinke – volume: 34 start-page: 220 year: 1996 ident: b49 article-title: A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity contributor: fullname: Ware – volume: 19 start-page: 206 year: 2010 ident: b40 article-title: Mefloquine prescriptions in the presence of contraindications: prevalence among US military personnel deployed to Afghanistan, 2007 contributor: fullname: Nevin – volume: 178 start-page: 966 year: 2013 ident: b41 article-title: The National Health Study for a new generation of United States veterans: methods for a large-scale study on the health of recent veterans contributor: fullname: Eber – year: 2017 ident: b8 contributor: fullname: Department of Veterans Affairs, Epidemiology Program, Post-Deployment Health Group – year: 2017 ident: b6 contributor: fullname: Fukuda – year: 2013 ident: b54 contributor: fullname: Yoon – volume: 86 start-page: 587 year: 2012 ident: b7 article-title: Compliance with antimalarial chemoprophylaxis in a combat zone contributor: fullname: Brisson – volume: 49 start-page: 1132 year: 2005 ident: b36 article-title: Mefloquine inhibits cholinesterases at the mouse neuromuscular junction contributor: fullname: McArdle – volume: 297 start-page: 2251 year: 2007 ident: b1 article-title: Controversies and misconceptions in malaria chemoprophylaxis for travelers contributor: fullname: Chen – volume: 13 start-page: 80 year: 2015 ident: b30 article-title: Acute and long-term psychiatric side effects of mefloquine: a follow-up on Danish adverse event reports contributor: fullname: Ringqvist – volume: 282 start-page: 1737 year: 1999 ident: b52 article-title: Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study contributor: fullname: Spitzer – volume: 2011 start-page: 1 year: 2011 ident: b43 article-title: Severe neuropsychiatric reaction in a deployed military member after prophylactic mefloquine contributor: fullname: Peterson – volume: 52 start-page: 1 year: 1997 ident: b57 article-title: Neuro-psychiatric effects of antimalarials contributor: fullname: Van Riemsdijk – year: 1997 ident: b55 contributor: fullname: Kuha – volume: 55 start-page: 230 year: 1996 ident: b61 article-title: Tolerance of mefloquine chemoprophylaxis in Dutch military personnel contributor: fullname: Jaspers – year: 2009 ident: b9 contributor: fullname: Office of the Assistant Secretary of Defense for Health Affairs – volume: 15 start-page: 332 year: 2016 ident: b69 article-title: Psychiatric effects of malaria and antimalarial drugs: historical and modern perspectives contributor: fullname: Nevin – volume: 51 start-page: 253 year: 2005 ident: b15 article-title: The efficacy and tolerability of doxycycline and mefloquine in malaria prophylaxis of the ISAF troops in Afghanistan contributor: fullname: Sonmez – volume: 27 start-page: 542 year: 2014 ident: b37 article-title: Prevalence of a positive screen for PTSD among OEF/OIF and OEF/OIF-Era veterans in a large population-based cohort contributor: fullname: Dursa – volume: 16 start-page: 297 year: 1951 ident: b48 article-title: Coefficient alpha and the internal structure of tests contributor: fullname: Cronbach – volume: 7 start-page: 571 year: 2008 ident: b18 article-title: The use and safety of doxycycline hyclate and other second-generation tetracyclines contributor: fullname: Sloan – volume: 49 start-page: 317 year: 2015 ident: b21 article-title: A critical review of the effects of hydroxychloroquine and chloroquine on the eye contributor: fullname: Costedoat-Chalumeau – volume: 29 start-page: 1502 year: 1999 ident: b67 article-title: Primaquine as prophylaxis for malaria for nonimmune travelers: a comparison with mefloquine and doxycycline contributor: fullname: Schwartz – year: 2013 ident: b10 contributor: fullname: Office of the Assistant Secretary of Defense for Health Affairs – year: 2013 ident: b35 contributor: fullname: Food and Drug Administration – volume: 1 start-page: 485 year: 1996 ident: b58 article-title: Mefloquine tolerability during chemoprophylaxis: focus on adverse event assessments, stereochemistry and compliance contributor: fullname: Schlagenhauf – volume: 11 start-page: 71 year: 2013 ident: b62 article-title: Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders contributor: fullname: Schneider – volume: 33 start-page: 194 year: 2007 ident: b3 article-title: Self-reported adverse events associated with antimalarial chemoprophylaxis in Peace Corps volunteers contributor: fullname: Korhonen – year: 2003 ident: b11 contributor: fullname: Armed Forces Epidemiological Board – volume: 99 start-page: 1651 year: 2009 ident: b38 article-title: Trends and risk factors for mental health diagnoses among Iraq and Afghanistan veterans using Department of Veterans Affairs health care, 2002–2008 contributor: fullname: Seal – volume: 16 start-page: 42 year: 2009 ident: b59 article-title: Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study contributor: fullname: Schlagenhauf – volume: 44 start-page: 257 year: 1993 ident: b45 article-title: Tolerability of prophylactic Lariam® regimens contributor: fullname: Boudreau – volume: 313 start-page: 525 year: 1996 ident: b56 article-title: Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers contributor: fullname: Barrett – volume: 74 start-page: 744 year: 2006 ident: b63 article-title: Mefloquine use and hospitalizations among US service members, 2002–2004 contributor: fullname: Wells – volume: 13 start-page: 418 year: 2014 ident: b23 article-title: Primaquine: the risks and the benefits contributor: fullname: Ashley – volume: 15 start-page: 903 year: 2016 ident: b46 article-title: Adverse neuropsychiatric effects of antimalarial drugs contributor: fullname: Grabias – volume: 27 start-page: 25 year: 2004 ident: b5 article-title: Antimalarial drug toxicity: a review contributor: fullname: Taylor – volume: 93 start-page: 584 year: 2015 ident: b14 article-title: Safety, tolerability, and compliance with long-term antimalarial chemoprophylaxis in American soldiers in Afghanistan contributor: fullname: Saunders – volume: 2015 start-page: 1 year: 2015 ident: b22 article-title: Side effects of chloroquine and primaquine and symptom reduction in malaria endemic area (Mâncio Lima, Acre, Brazil) contributor: fullname: Braga – year: 2014 ident: b42 contributor: fullname: Dillman – volume: 180 start-page: 374 year: 2015 ident: b39 article-title: Health care utilization behavior of veterans who deployed to Afghanistan and Iraq contributor: fullname: Lee – volume: 75 start-page: 402 year: 2006 ident: b24 article-title: Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I contributor: fullname: Hill – volume: 105 start-page: 568 year: 2011 ident: b66 article-title: Evaluation of the safety and tolerability of a short higher-dose primaquine regimen for presumptive anti-relapse therapy in healthy subjects contributor: fullname: Ebringer – volume: 53 start-page: 385 year: 2007 ident: b4 article-title: Antimalarial drug toxicity: a review contributor: fullname: Alkadi – volume: 8 start-page: S48 year: 2001 ident: b20 article-title: Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety contributor: fullname: Jong – volume: 96 start-page: 159 year: 2017 ident: b29 article-title: Neuropsychiatric outcomes after mefloquine exposure among US military service members contributor: fullname: Eick-Cost |
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Snippet | Mefloquine (Lariam
; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may... Mefloquine (Lariam ® ; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who... Mefloquine (Lariam®; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who may... Mefloquine (Lariam ® ; Roche Holding AG, Basel, Switzerland) has been linked to acute neuropsychiatric side effects. This is a concern for U.S. veterans who... |
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SubjectTerms | Drug therapy Malaria Mental health Military deployment Preventive medicine Side effects Veterans |
Title | Associations between Use of Antimalarial Medications and Health among U.S. Veterans of the Wars in Iraq and Afghanistan |
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