Hepatoprotective effect of silymarin
The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from t...
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| Published in | World journal of hepatology Vol. 6; no. 3; pp. 144 - 149 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Baishideng Publishing Group Co., Limited
27.03.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1948-5182 1948-5182 |
| DOI | 10.4254/wjh.v6.i3.144 |
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| Abstract | The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from the species Silybum marianum,which is commonly known as Milk thistle.This plant contains at least seven flavoligands and the flavonoid taxifolin.The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon tetrachloride.The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation.Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. |
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| AbstractList | The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum marianum,Phyllanthus niruri,and Panus giganteus(Berk.)have been shown to ameliorate hepatic lesions.Silymarin is a natural compound derived from the species Silybum marianum,which is commonly known as Milk thistle.This plant contains at least seven flavoligands and the flavonoid taxifolin.The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol,acetaminophen,and carbon tetrachloride.The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation.Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity.A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls.The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum , Phyllanthus niruri , and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum , which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. |
| Author | Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y González-Rubio Juan A Gayosso-de-Lucio José A Morales-González |
| AuthorAffiliation | Institute of Health Sciences,Autonomous University of Hidalgo State Laboratorio Medicina de Conservación,Escuela Superior de Medicina,Instituto Politécnico Nacional Escuela Superior de Cómputo,Instituto Politécnico Nacional,Av.Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal,Unidad Profesional Adolfo López Mateos Faculty of Dentistry,UNAM |
| Author_xml | – sequence: 1 fullname: Nancy Vargas-Mendoza Eduardo Madrigal-Santillán ngel Morales-González Jaime Esquivel-Soto Cesar Esquivel-Chirino Manuel García-Luna y González-Rubio Juan A Gayosso-de-Lucio José A Morales-González |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24672644$$D View this record in MEDLINE/PubMed |
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| Issue | 3 |
| Keywords | Silybum marianum Silymarin Hepatoprotector Lipoperoxidation |
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| Notes | Nancy Vargas-Mendoza;Eduardo Madrigal-Santillán;ngel Morales-González;Jaime Esquivel-Soto;Cesar Esquivel-Chirino;Manuel García-Luna y González-Rubio;Juan A Gayosso-de-Lucio;José A Morales-González;Institute of Health Sciences,Autonomous University of Hidalgo State;Laboratorio Medicina de Conservación,Escuela Superior de Medicina,Instituto Politécnico Nacional;Escuela Superior de Cómputo,Instituto Politécnico Nacional,Av.Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal,Unidad Profesional Adolfo López Mateos;Faculty of Dentistry,UNAM ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Author contributions: All of the authors participated equally in the creation of this document. Telephone: +1-55-57296300-62753 Fax: +1-55-53963503 Correspondence to: José A Morales-González, MD, PhD, Laboratorio Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, México City 11340, México. jmorales101@yahoo.com.mx |
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| PublicationTitle | World journal of hepatology |
| PublicationTitleAlternate | World Journal of Hepatology |
| PublicationYear | 2014 |
| Publisher | Baishideng Publishing Group Co., Limited |
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| Snippet | The use of medicinal plants in treating illnesses has been reported since ancestral times.In the case of hepatic diseases,several species such as Silybum... The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum... The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum... |
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| SubjectTerms | Hepatoprotector Lipoperoxidation marianum Minireviews Silybum Silymarin |
| Title | Hepatoprotective effect of silymarin |
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