Melittin as a Permeability Enhancer II: In Vitro Investigations in Human Mucus Secreting Intestinal Monolayers and Rat Colonic Mucosae - Maher, Sam; Feighery, Linda; Brayden, David J.; McClean, Siobhán (Pharmaceutical research, 2007)
Keywords: Animals; Bioavailability; Biochemistry; Biological and medical sciences; Caco-2 Cells; Calcium-binding protein; Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Calmodulin; Calmodulin - metabolism; Cell Survival - drug effects; Cellular biology; Colon; Colon - drug effects; Colon - metabolism; Cytotoxicity; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Drug delivery; Drug Stability; Electric Impedance; Electrical resistivity; General pharmacology; Hemolysis - drug effects; HT29 Cells; Human subjects; Humans; In Vitro Techniques; Intestinal Absorption - drug effects; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestine; Ions; Large intestine; Male; Mannitol; Mannitol - metabolism; Medical sciences; Melitten - chemistry; Melitten - pharmacology; Membrane Potentials - drug effects; Mucosa; Mucus; Mucus - metabolism; Peptides; Permeability; Permeability - drug effects; Pharmaceutical technology. Pharmaceutical industry; Pharmacology; Pharmacology. Drug treatments; Protein Kinase Inhibitors - pharmacology; Rats; Rats, Sprague-Dawley; Rodents; Sheep; Short-circuit current; Small intestine; Sulfonamides - pharmacology; Transmission electron microscopy; Tritium; Human; Stomach; Pharmaceutical technology; gastrointestinal permeability models; Peptides; Rat; melittin; Rodentia; Gut; Oral administration; oral peptide delivery; Mucus; Permeability; Gastrointestinal; In vitro; Vertebrata; Mammalia; Animal; ussing chambers; Absorption enhancer; Colon