The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma
Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell recept...
Saved in:
| Published in | Cancer letters Vol. 593; p. 216951 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.07.2024
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-3835 1872-7980 1872-7980 |
| DOI | 10.1016/j.canlet.2024.216951 |
Cover
Loading…
| Abstract | Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell receptor (scTCR/scBCR) sequencing of CD45+ immune cells on samples from 10 patients who received neoadjuvant immunotherapy and chemotherapy. We also validated our findings using multiplexed immunofluorescence and analyzed bulk RNA-seq from other cohorts in public database. By integrating analysis of 87357 CD45+ cells, we found GZMK + effector memory T cells (Tem) were relatively enriched and CXCL13+ exhausted T cells (Tex) and regulator T cells (Treg) decreased among responders, indicating a persistent anti-tumor memory process. Additionally, the enhanced presence of BCR expansion and somatic hypermutation process within TNFRSF13B + memory B cells (Bmem) suggested their roles in antigen presentation. This was further corroborated by the evidence of the T-B co-stimulation pattern and CXCL13-CXCR5 axis. The complexity of myeloid cell heterogeneity was also particularly pronounced. The elevated expression of S100A7 in ESCC, as detected by bulk RNA-seq, was associated with an exhausted and immunosuppressive tumor microenvironment. In summary, this study has unveiled a potential regulatory network among immune cells and the clonal dynamics of their functions, and the mechanisms of exhaustion and memory conversion between GZMK + Tem and TNFRSF13B + Bmem from antigen presentation and co-stimulation perspectives during neoadjuvant PD-1 blockade treatment in ESCC.
•By integrating analysis of 87357 CD45+ cells, we defined CD8+ CXCL13+ exhausted T cells (Tex) were enriched and clonal expanded in the non-responsive patients and CD4+ LAIR2+Treg were in activated states and highly plastic with various clonal sharing, which pointed out an exhausted and immunosuppressive environment in non-responsive patient following PD-1 blockade treatment. While, GZMK + effector memory T cells (Tem) were relatively enriched in responders, which suggested a memory lasting anti-tumor process with the stem-like ab + and FCRL4+ memory B (Bmem) with more differentiated states and the BCR expansion phenomenon were observed in responders. The class-switch recombination (CSR) and somatic hypermutation (SHM) process were also enriched in TNFRSF13B + Bmem implying its mature state as antigen-presenting (APC) roles. Furthermore, T-B crosstalk process via CD28−CD86 co-stimulation pattern and CXCL13-CXCR5 chemokines axis was validated using cellphoneDB algorithm and multiplex immunofluorescence (mIF) method. We also extracted a TNFRSF13B signature to predict response and OS benefits to immune checkpoint blockade in different cohorts to underscore their clinical relevance.•And the heterogeneity of myeloid cells was quite complex. According to pan-cancer results, we also validated FOLR2+ tissue-resident macrophage in our cohort showed a correlation with increment of Tem clusters, suggesting its APC roles. On the contrary, CCL3L1+ Neutrophils tended to a pro-tumoral phenotype with immunosuppressive and neutrophil extracellular traps (NETs) features.•While the elevated S100A7 in our ESCC cohort revealed by bulk RNA-seq relating to an exhaustion and immunosuppressive TME in upstream pathway may explain the inherent ICB resistance mechanism. |
|---|---|
| AbstractList | Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell receptor (scTCR/scBCR) sequencing of CD45+ immune cells on samples from 10 patients who received neoadjuvant immunotherapy and chemotherapy. We also validated our findings using multiplexed immunofluorescence and analyzed bulk RNA-seq from other cohorts in public database. By integrating analysis of 87357 CD45+ cells, we found GZMK + effector memory T cells (Tem) were relatively enriched and CXCL13+ exhausted T cells (Tex) and regulator T cells (Treg) decreased among responders, indicating a persistent anti-tumor memory process. Additionally, the enhanced presence of BCR expansion and somatic hypermutation process within TNFRSF13B + memory B cells (Bmem) suggested their roles in antigen presentation. This was further corroborated by the evidence of the T-B co-stimulation pattern and CXCL13-CXCR5 axis. The complexity of myeloid cell heterogeneity was also particularly pronounced. The elevated expression of S100A7 in ESCC, as detected by bulk RNA-seq, was associated with an exhausted and immunosuppressive tumor microenvironment. In summary, this study has unveiled a potential regulatory network among immune cells and the clonal dynamics of their functions, and the mechanisms of exhaustion and memory conversion between GZMK + Tem and TNFRSF13B + Bmem from antigen presentation and co-stimulation perspectives during neoadjuvant PD-1 blockade treatment in ESCC.
•By integrating analysis of 87357 CD45+ cells, we defined CD8+ CXCL13+ exhausted T cells (Tex) were enriched and clonal expanded in the non-responsive patients and CD4+ LAIR2+Treg were in activated states and highly plastic with various clonal sharing, which pointed out an exhausted and immunosuppressive environment in non-responsive patient following PD-1 blockade treatment. While, GZMK + effector memory T cells (Tem) were relatively enriched in responders, which suggested a memory lasting anti-tumor process with the stem-like ab + and FCRL4+ memory B (Bmem) with more differentiated states and the BCR expansion phenomenon were observed in responders. The class-switch recombination (CSR) and somatic hypermutation (SHM) process were also enriched in TNFRSF13B + Bmem implying its mature state as antigen-presenting (APC) roles. Furthermore, T-B crosstalk process via CD28−CD86 co-stimulation pattern and CXCL13-CXCR5 chemokines axis was validated using cellphoneDB algorithm and multiplex immunofluorescence (mIF) method. We also extracted a TNFRSF13B signature to predict response and OS benefits to immune checkpoint blockade in different cohorts to underscore their clinical relevance.•And the heterogeneity of myeloid cells was quite complex. According to pan-cancer results, we also validated FOLR2+ tissue-resident macrophage in our cohort showed a correlation with increment of Tem clusters, suggesting its APC roles. On the contrary, CCL3L1+ Neutrophils tended to a pro-tumoral phenotype with immunosuppressive and neutrophil extracellular traps (NETs) features.•While the elevated S100A7 in our ESCC cohort revealed by bulk RNA-seq relating to an exhaustion and immunosuppressive TME in upstream pathway may explain the inherent ICB resistance mechanism. Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell receptor (scTCR/scBCR) sequencing of CD45 immune cells on samples from 10 patients who received neoadjuvant immunotherapy and chemotherapy. We also validated our findings using multiplexed immunofluorescence and analyzed bulk RNA-seq from other cohorts in public database. By integrating analysis of 87357 CD45 cells, we found GZMK + effector memory T cells (Tem) were relatively enriched and CXCL13+ exhausted T cells (Tex) and regulator T cells (Treg) decreased among responders, indicating a persistent anti-tumor memory process. Additionally, the enhanced presence of BCR expansion and somatic hypermutation process within TNFRSF13B + memory B cells (Bmem) suggested their roles in antigen presentation. This was further corroborated by the evidence of the T-B co-stimulation pattern and CXCL13-CXCR5 axis. The complexity of myeloid cell heterogeneity was also particularly pronounced. The elevated expression of S100A7 in ESCC, as detected by bulk RNA-seq, was associated with an exhausted and immunosuppressive tumor microenvironment. In summary, this study has unveiled a potential regulatory network among immune cells and the clonal dynamics of their functions, and the mechanisms of exhaustion and memory conversion between GZMK + Tem and TNFRSF13B + Bmem from antigen presentation and co-stimulation perspectives during neoadjuvant PD-1 blockade treatment in ESCC. Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell receptor (scTCR/scBCR) sequencing of CD45+ immune cells on samples from 10 patients who received neoadjuvant immunotherapy and chemotherapy. We also validated our findings using multiplexed immunofluorescence and analyzed bulk RNA-seq from other cohorts in public database. By integrating analysis of 87357 CD45+ cells, we found GZMK + effector memory T cells (Tem) were relatively enriched and CXCL13+ exhausted T cells (Tex) and regulator T cells (Treg) decreased among responders, indicating a persistent anti-tumor memory process. Additionally, the enhanced presence of BCR expansion and somatic hypermutation process within TNFRSF13B + memory B cells (Bmem) suggested their roles in antigen presentation. This was further corroborated by the evidence of the T-B co-stimulation pattern and CXCL13-CXCR5 axis. The complexity of myeloid cell heterogeneity was also particularly pronounced. The elevated expression of S100A7 in ESCC, as detected by bulk RNA-seq, was associated with an exhausted and immunosuppressive tumor microenvironment. In summary, this study has unveiled a potential regulatory network among immune cells and the clonal dynamics of their functions, and the mechanisms of exhaustion and memory conversion between GZMK + Tem and TNFRSF13B + Bmem from antigen presentation and co-stimulation perspectives during neoadjuvant PD-1 blockade treatment in ESCC.Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its impact on treatment sensitivity or resistance remain a subject of controversy. In this study, we conducted single-cell RNA and T/B cell receptor (scTCR/scBCR) sequencing of CD45+ immune cells on samples from 10 patients who received neoadjuvant immunotherapy and chemotherapy. We also validated our findings using multiplexed immunofluorescence and analyzed bulk RNA-seq from other cohorts in public database. By integrating analysis of 87357 CD45+ cells, we found GZMK + effector memory T cells (Tem) were relatively enriched and CXCL13+ exhausted T cells (Tex) and regulator T cells (Treg) decreased among responders, indicating a persistent anti-tumor memory process. Additionally, the enhanced presence of BCR expansion and somatic hypermutation process within TNFRSF13B + memory B cells (Bmem) suggested their roles in antigen presentation. This was further corroborated by the evidence of the T-B co-stimulation pattern and CXCL13-CXCR5 axis. The complexity of myeloid cell heterogeneity was also particularly pronounced. The elevated expression of S100A7 in ESCC, as detected by bulk RNA-seq, was associated with an exhausted and immunosuppressive tumor microenvironment. In summary, this study has unveiled a potential regulatory network among immune cells and the clonal dynamics of their functions, and the mechanisms of exhaustion and memory conversion between GZMK + Tem and TNFRSF13B + Bmem from antigen presentation and co-stimulation perspectives during neoadjuvant PD-1 blockade treatment in ESCC. |
| ArticleNumber | 216951 |
| Author | Chen, Yuting Hong, Hui Hu, Weilei Chen, Xiao Wu, Zhigang Wang, Zheyi Liu, Pengcheng Liu, Chunnan Wo, Yang Zhao, Yue Peng, Yizhou Shang, Yan Sun, Yihua Huang, Kan Li, Fei |
| Author_xml | – sequence: 1 givenname: Zheyi orcidid: 0000-0002-5016-3647 surname: Wang fullname: Wang, Zheyi organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 2 givenname: Yue surname: Zhao fullname: Zhao, Yue organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 3 givenname: Yang surname: Wo fullname: Wo, Yang organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 4 givenname: Yizhou surname: Peng fullname: Peng, Yizhou organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 5 givenname: Weilei surname: Hu fullname: Hu, Weilei organization: School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China – sequence: 6 givenname: Zhigang surname: Wu fullname: Wu, Zhigang organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 7 givenname: Pengcheng surname: Liu fullname: Liu, Pengcheng organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 8 givenname: Yan surname: Shang fullname: Shang, Yan organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 9 givenname: Chunnan orcidid: 0000-0002-6396-1672 surname: Liu fullname: Liu, Chunnan organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 10 givenname: Xiao orcidid: 0009-0003-8784-554X surname: Chen fullname: Chen, Xiao organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 11 givenname: Kan orcidid: 0009-0004-3697-2909 surname: Huang fullname: Huang, Kan organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 12 givenname: Yuting orcidid: 0009-0003-7741-9547 surname: Chen fullname: Chen, Yuting organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 13 givenname: Hui surname: Hong fullname: Hong, Hui organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China – sequence: 14 givenname: Fei surname: Li fullname: Li, Fei email: li_fei@fudan.edu.cn organization: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China – sequence: 15 givenname: Yihua surname: Sun fullname: Sun, Yihua email: sun_yihua76@hotmail.com organization: Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38734159$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUtv1DAUhS1URKeFf4CQl2wy-JGHgxASqmhBqsSmrK07zs2MB8dObafSrPnjZJQpi25mdaWr8537OFfkwgePhLznbM0Zrz_t1wa8w7wWTJRrweu24q_IiqtGFE2r2AVZMcnKQipZXZKrlPaMsapsqjfkUqpGlrxqV-Tvww5psn7rkBp0jtphmHzYog-DNdSB75KBESn0GSP1GKDbT0_g80mZdxhhPFATho312FGzw-F_13qKKYw72CI4mh4nGMKUlkkGorHzGHhLXvfgEr471Wvy-_b7w82P4v7X3c-bb_eFmXfNRWXEZlOVqhSK19CrVpge-0a1PbRQSSlR1armKIQRskVVIWJdt2UJnewkGnlNPi6-YwyPE6asB5uOq8B81pS0ZJVsFS8Fm6UfTtJpM2Cnx2gHiAf9_LhZ8HkRmBhSithrYzNkG3yOYJ3mTB9T0nu9pKSPKeklpRkuX8DP_mewrwuG85OeLEadjEVvsLMRTdZdsOcMvrwwMM56a8D9wcN5_B-hlcU9 |
| CitedBy_id | crossref_primary_10_3389_fimmu_2025_1535464 crossref_primary_10_1016_j_canlet_2024_217267 crossref_primary_10_1515_oncologie_2024_0339 crossref_primary_10_1039_D4NR05114A crossref_primary_10_1016_j_canlet_2025_217600 |
| Cites_doi | 10.1158/2159-8290.CD-22-1046 10.1056/NEJMoa2032125 10.1084/jem.20031571 10.1016/j.ccell.2023.09.011 10.1016/j.ebiom.2023.104515 10.1038/s41591-019-0750-6 10.1016/j.annonc.2021.10.218 10.1038/s43018-021-00292-8 10.1126/science.abf9419 10.1038/s41586-019-1922-8 10.1038/s41586-023-06199-x 10.1038/s41586-020-2134-y 10.1053/j.gastro.2017.08.023 10.1038/s41586-022-05400-x 10.1136/jitc-2021-004210 10.1016/j.cell.2021.01.010 10.1038/s41568-023-00560-y 10.1016/j.immuni.2021.02.014 10.1186/s13073-023-01164-9 10.1200/JCO.20.01888 10.1016/j.cytogfr.2014.01.001 10.1073/pnas.1320318110 10.1038/s41422-023-00909-w 10.1038/s41586-018-0694-x 10.1186/s13045-020-00939-6 10.1038/s41392-023-01337-3 10.1146/annurev-immunol-110519-071134 10.1016/j.immuni.2022.02.001 10.1016/j.immuni.2023.06.017 10.1038/nmeth.3317 10.1038/s41586-022-05593-1 10.1038/srep00765 10.3322/caac.21660 10.1002/ctm2.459 10.1038/s41467-021-25539-x 10.1186/s12943-021-01331-9 10.1016/j.cell.2022.06.018 10.1038/s41588-023-01499-4 10.12688/f1000research.22139.1 10.1016/j.cell.2022.02.021 10.3389/fimmu.2022.1075260 10.1016/j.cell.2018.10.038 10.1016/j.ccell.2023.03.016 10.1038/s41591-021-01323-8 10.1158/0008-5472.CAN-22-3140 10.1038/s41392-023-01518-0 10.1016/j.ccell.2022.02.002 10.1002/1878-0261.13053 10.1038/s41586-023-06511-9 10.1038/s41591-023-02469-3 10.1038/s41587-020-0505-4 10.1038/s43018-022-00433-7 10.1136/jitc-2021-004291 10.1016/j.ccell.2023.08.001 10.1038/s41586-024-07135-3 10.1038/s41392-022-01196-4 10.1016/j.cell.2020.02.015 10.1002/advs.202204565 10.1056/NEJMoa1801946 10.1016/j.cell.2023.02.032 10.4049/jimmunol.177.12.8315 10.3389/fimmu.2022.954936 10.1038/nrclinonc.2017.101 10.1016/j.cell.2023.03.031 10.1158/2159-8290.CD-21-1658 10.1016/j.ccell.2022.04.005 10.1016/j.ebiom.2022.104371 10.1038/s41591-018-0045-3 10.1038/s41586-023-06231-0 10.1038/s41587-020-0462-y 10.1126/sciimmunol.adf4968 10.1016/j.cell.2019.08.032 10.1093/bioinformatics/btv359 10.1016/j.cell.2019.06.029 10.1016/j.cell.2021.11.007 10.1016/j.ctrv.2021.102227 10.1093/bioinformatics/btu638 |
| ContentType | Journal Article |
| Copyright | 2024 Elsevier B.V. Copyright © 2024 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2024 Elsevier B.V. – notice: Copyright © 2024 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.canlet.2024.216951 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1872-7980 |
| ExternalDocumentID | 38734159 10_1016_j_canlet_2024_216951 S0304383524003446 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29B 4.4 457 4CK 4G. 5GY 5RE 5VS 6J9 6PF 7-5 71M 8FE 8FH 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAWTL AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABGSF ABJNI ABMAC ABMZM ABUDA ACDAQ ACGFO ACGFS ACIEU ACIUM ACPRK ACRLP ACVFH ADBBV ADCNI ADEZE ADFRT ADUVX AEBSH AEFWE AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRAH AFRHN AFTJW AFXIZ AGCQF AGHFR AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP AXJTR BKEYQ BKOJK BLXMC BNPGV BPHCQ BVXVI CS3 DU5 EBS EFJIC EFKBS EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IH2 IHE J1W K-O KOM LK8 M29 M41 MO0 N9A O-L O9- OAUVE OC~ OO- OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 ROL RPZ SCC SDF SDG SDP SEL SES SPCBC SSH SSU SSZ T5K Z5R ~G- 7RV 7X7 8C1 AACTN AAIAV AFCTW AFKRA AFKWA AJOXV AMFUW AZQEC BBNVY BENPR HCIFZ M2M M2O M7P RIG SEW .55 .GJ 3O- 53G AAQXK AAYXX ABWVN ABXDB ACRPL ADMUD ADNMO AFFNX AGQPQ AGRDE AGRNS AI. ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HED HMK HMO HVGLF HZ~ R2- SAE UDS VH1 WUQ X7M ZGI CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c415t-5c2bb54842816af892cfef789fa9a5333e86861e22c239e85eee66944ad3d3ec3 |
| IEDL.DBID | .~1 |
| ISSN | 0304-3835 1872-7980 |
| IngestDate | Thu Jul 10 23:13:22 EDT 2025 Wed Feb 19 02:09:39 EST 2025 Thu Apr 24 23:08:58 EDT 2025 Tue Jul 01 02:29:50 EDT 2025 Sat Jul 13 15:31:43 EDT 2024 Tue Aug 26 16:33:35 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | Copyright © 2024 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c415t-5c2bb54842816af892cfef789fa9a5333e86861e22c239e85eee66944ad3d3ec3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0009-0003-8784-554X 0009-0004-3697-2909 0009-0003-7741-9547 0000-0002-5016-3647 0000-0002-6396-1672 |
| PMID | 38734159 |
| PQID | 3053981420 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3053981420 pubmed_primary_38734159 crossref_citationtrail_10_1016_j_canlet_2024_216951 crossref_primary_10_1016_j_canlet_2024_216951 elsevier_sciencedirect_doi_10_1016_j_canlet_2024_216951 elsevier_clinicalkey_doi_10_1016_j_canlet_2024_216951 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-07-01 2024-07-00 2024-Jul-01 20240701 |
| PublicationDateYYYYMMDD | 2024-07-01 |
| PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Cancer letters |
| PublicationTitleAlternate | Cancer Lett |
| PublicationYear | 2024 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Goto, Westcott, Goto, Imada, Taylor, Eng, Braverman, Deshpande, Jacks, Agudo, Yilmaz (bib34) 2024; 627 Zhang, Yu, Zheng, Zhang, Li, Fang, Gao, Kang, Zhang, Huang, Konno, Guo, Ye, Gao, Wang, Hu, Ren, Shen, Ouyang, Zhang (bib42) 2018; 564 Jaiswal, Verma, Dannenfelser, Melssen, Tirosh, Izar, Kim, Nirschl, Devi, Olson, Slingluff, Engelhard, Garraway, Regev, Minkis, Yoon, Troyanskaya, Elemento, Suarez-Farinas, Anandasabapathy (bib78) 2022; 40 Schumacher, Thommen (bib58) 2022; 375 Liu, Zhang, Ma, Yang, Ma, Wang, Wang, Wei, Chen, Tartarone, Velotta, Dayyani, Gabriel, Wakefield, Kidane, Carbonelli, Long, Liu, Su, Li (bib9) 2023; 41 Feig, Jones, Kraman, Wells, Deonarine, Chan, Connell, Roberts, Zhao, Caballero, Teichmann, Janowitz, Jodrell, Tuveson, Fearon (bib19) 2013; 110 Kruse, Buzzai, Shridhar, Braun, Gellert, Knauth, Pozniak, Peters, Dittmann, Mengoni, van der Sluis, Hohn, Antoranz, Krone, Fu, Yu, Essand, Geffers, Mougiakakos, Kahlfuss, Kashkar, Gaffal, Bosisio, Bechter, Rambow, Marine, Kastenmuller, Muller, Tuting (bib60) 2023; 618 Fang, Stehr, Naschberger, Knopf, Herrmann, Stuerzl (bib68) 2022; 13 Guo, Zhang, Zheng, Zheng, Song, Zhang, Kang, Liu, Jin, Xing, Gao, Zhang, Dong, Hu, Ren, Kirchhoff, Roider, Yan, Zhang (bib52) 2018; 24 J. Yin, J. Yuan, Y. Li, Y. Fang, R. Wang, H. Jiao, H. Tang, S. Zhang, S. Lin, F. Su, J. Gu, T. Jiang, D. Lin, Z. Huang, C. Du, K. Wu, L. Tan, Q. Zhou, Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial, Nat. Med. 29 (2023) 2068-+. Laughney, Hu, Campbell, Bakhoum, Setty, Lavallee, Xie, Masilionis, Carr, Kottapalli, Allaj, Mattar, Rekhtman, Xavier, Mazutis, Poirier, Rudin, Pe'er, Massague (bib35) 2020; 26 Rastogi, Jeon, Moseman, Muralidhar, Potluri, McNeel (bib75) 2022; 13 Bassez, Vos, Van Dyck, Floris, Arijs, Desmedt, Boeckx, Vanden Bempt, Nevelsteen, Lambein, Punie, Neven, Garg, Wildiers, Qian, Smeets, Lambrechts (bib7) 2021; 27 Chen, Wang, Jin, Zhao, Liu, Zuo, Ju, Cui, Yao, Zhang, Li, Feng, Tian, Xia, Feng, Yao, Wang, Li, Wang, Xu (bib33) 2023; 41 Chiou, Tseng, Reuben, Mallajosyula, Molina, Conley, Wilhelmy, McSween, Yang, Nishimiya, Sinha, Nabet, Wang, Shrager, Berry, Backhus, Lui, Wakelee, Neal, Padda, Berry, Delaidelli, Sorensen, Sotillo, Tran, Benson, Richards, Labanieh, Klysz, Louis, Feldman, Diehn, Weissman, Zhang, Wistuba, Futreal, Heymach, Garcia, Mackall, Davis (bib53) 2021; 54 Shang, Zhang, Zhao, Zhang, Liu, Duan, Yue, Ma, Chen, Meng, Ren, Jiang (bib6) 2021; 32 Liu, Zhang, Wang, Hu, Zhang (bib48) 2022; 3 Smillie, Biton, Ordovas-Montanes, Sullivan, Burgin, Graham, Herbst, Rogel, Slyper, Waldman, Sud, Andrews, Velonias, Haber, Jagadeesh, Vickovic, Yao, Stevens, Dionne, Nguyen, Villani, Hofree, Creasey, Huang, Rozenblatt-Rosen, Garber, Khalili, Desch, Daly, Ananthakrishnan, Shalek, Xavier, Regev (bib47) 2019; 178 Fang, Che, Zhang, Huang, Lei, Lu, Sun, He (bib72) 2021; 15 Ren, Zhang, Zhang, Li, Siemers, Zhang (bib49) 2021; 39 Zhang, Guo, Dai, Shang, Xiao, Di, Zhang, Feng, Shou, Wang (bib46) 2022; 10 Luoma, Suo, Wang, Gunasti, Porter, Nabilsi, Tadros, Ferretti, Liao, Gurer, Chen, Criscitiello, Ricker, Dionne, Rozenblatt-Rosen, Uppaluri, Haddad, Ashenberg, Regev, Van Allen, MacBeath, Schoenfeld, Wucherpfennig (bib8) 2022; 185 Wolf, Bartok, Patkar, Eli, Cohen, Litchfield, Levy, Jimenez-Sanchez, Trabish, Lee, Karathia, Barnea, Day, Cinnamon, Stein, Solomon, Bitton, Perez-Guijarro, Dubovik, Shen-Orr, Miller, Merlino, Levin, Pikarsky, Eisenbach, Admon, Swanton, Ruppin, Samuels (bib31) 2019; 179 Ly, Li, Navab, Zeltz, Fang, Cabanero, Zhu, Tsao, Zhang (bib51) 2022; 14 Liu, Zheng, Lu, Wang, Wang, Feng, Wang, Sun, He (bib71) 2022; 7 Borcherding, Bormann, Kraus (bib41) 2020; 9 Abnet, Arnold, Wei (bib2) 2018; 154 Messina, Fenstermacher, Eschrich, Qu, Berglund, Lloyd, Schell, Sondak, Weber, Mule (bib57) 2012; 2 de Vries, van de Haar, Veninga, Chalabi, Ijsselsteijn, van der Ploeg, van den Bulk, Ruano, van den Berg, Haanen, Zeverijn, Geurts, de Wit, Battaglia, Gelderblom, Verheul, Schumacher, Wessels, Koning, de Miranda, Voest (bib79) 2023; 613 Cortes, Georgopoulos (bib56) 2004; 199 Gungabeesoon, Gort-Freitas, Kiss, Bolli, Messemaker, Siwicki, Hicham, Bill, Koch, Cianciaruso, Duval, Pfirschke, Mazzola, Peters, Homicsko, Garris, Weissleder, Klein, Pittet (bib65) 2023; 186 Yang, Li, Yu, Ding, Chen, Zeng, He, Liao, Zhao, Yuan (bib23) 2023; 8 Fridman, Zitvogel, Sautes-Fridman, Kroemer (bib12) 2017; 14 Cheng, Li, Gao, Xing, Gao, Yang, Qin, Zhang, Ouyang, Du, Jiang, Zhang, Yang, Wang, Ren, Bei, Hu, Bu, Ji, Zhang (bib45) 2021; 184 Fan, Gao, Zhao, Wang, Meng, Ma, Li, Han, Lai, Gao, Li, Guo, Cao, Zhang, Zhang, Chen (bib63) 2023; 83 Wang, Xiang, Xin, Wang, Peng, Liu, Wang, Li, Cheng, Lyv, Cui, Ma, Zhang, Xin (bib74) 2020; 13 Meylan, Petitprez, Becht, Bougouin, Pupier, Calvez, Giglioli, Verkarre, Lacroix, Verneau, Sun, Laurent-Puig, Vano, Elaidi, Mejean, Sanchez-Salas, Barret, Cathelineau, Oudard, Reynaud, de Reynies, Sautes-Fridman, Fridman (bib38) 2022; 55 Omoto, Tokime, Yamanaka, Habe, Morioka, Kurokawa, Tsutsui, Yamanishi, Nakanishi, Mizutani (bib62) 2006; 177 Sattiraju, Kang, Giotti, Chen, Marallano, Brusco, Ramakrishnan, Shen, Tsankov, Hambardzumyan, Friedel, Zou (bib36) 2023; 56 Liu, Hu, Feng, Gao, Xue, Zhang, Zhang, Corse, Hu, Han, Zhang (bib11) 2022; 3 Sung, Ferlay, Siegel, Laversanne, Soerjomataram, Jemal, Bray (bib1) 2021; 71 Klichinsky, Ruella, Shestova, Lu, Best, Zeeman, Schmierer, Gabrusiewicz, Anderson, Petty, Cummins, Shen, Shan, Veliz, Blouch, Yashiro-Ohtani, Kenderian, Kim, O'Connor, Wallace, Kozlowski, Marchione, Shestov, Garcia, June, Gill (bib76) 2020; 38 Liu, Yang, Liu (bib5) 2022; 10 Jia, Zhang, Zhang, Kwong, Chang, Li, Wang, Han, Li, Zhong, Sui, Fu, Guan, Qin (bib21) 2023; 10 Gupta, Vander Heiden, Uduman, Gadala-Maria, Yaari, Kleinstein (bib44) 2015; 31 Zhang, Dong, Tu, Li, Deng, Xu, He, Ding, Xia, Sheng, Chang, Ma, Dong, Zhang, Zhang, Zhang, Liu (bib82) 2023; 8 Ge, Jin, Ma, Wang, Liu, Zhou, Zhao, Yu, Liu, Di, Shao, Jiang (bib32) 2024; 34 Zhang, Yuan, Pan, Xu, Cui, Zhang, Liu, Song, Wu, Wu, Luo, Hu, Jiao, Yang (bib25) 2023; 90 Oliveira, Wu (bib10) 2023; 23 Cui, Wang, Fagerberg, Chen, Connolly, Damo, Cheung, Mao, Askari, Chen, Fitzgerald, Foster, Eisenbarth, Zhao, Craft, Joshi (bib69) 2021; 184 Westcott, Muyas, Hauck, Smith, Sacks, Ely, Jaeger, Rideout, Zhang, Bhutkar, Beytagh, Canner, Jaramillo, Bronson, Naranjo, Jin, Patten, Cruz, Shanahan, Cortes-Ciriano, Jacks (bib29) 2023; 55 Sade-Feldman, Yizhak, Bjorgaard, Ray, de Boer, Jenkins, Lieb, Chen, Frederick, Barzily-Rokni, Freeman, Reuben, Hoover, Villani, Ivanova, Portell, Lizotte, Aref, Eliane, Hammond, Vitzthum, Blackmon, Li, Gopalakrishnan, Reddy, Cooper, Paweletz, Barbie, Stemmer-Rachamimov, Flaherty, Wargo, Boland, Sullivan, Getz, Hacohen (bib15) 2018; 175 Bianchi, De Castro Silva, Deshpande, Singh, Mehra, Garrido, Guo, Nivelo, Kolonias, Saigh, Wieder, Rafie, Dosch, Zhou, Umland, Amirian, Ogobuiro, Zhang, Ban, Shiau, Nagathihalli, Montgomery, Hwang, Brambilla, Komanduri, Villarino, Toska, Stanger, Gabrilovich, Merchant, Datta (bib81) 2023; 13 Hao, Han, Sinjab, Gomez-Bolanos, Lazcano, Serrano, Hernandez, Dai, Cao, Hu, Dang, Wang, Chu, Song, Zhang, Parra, Wargo, Swisher, Cascone, Sepesi, Futreal, Li, Dubinett, Fujimoto, Solis Soto, Wistuba, Stevenson, Spira, Shalapour, Kadara, Wang (bib37) 2022; 12 Wen, Fang, Hu, Xi, Weng, Pan, Luo, Ling, Lai, Xie, Lin, Lin, Chen, Liu, Fu, Yang (bib22) 2022; 86 Liu, Yang, Liu, Fu, Cai, Li, Zhu, Shen, Zhang, Sun, Chen, Yu, Zhang, Shao, Zhang, Li (bib27) 2022; 10 Kelly, Ajani, Kuzdzal, Zander, Van Cutsem, Piessen, Mendez, Feliciano, Motoyama, Lievre, Uronis, Elimova, Grootscholten, Geboes, Zafar, Snow, Ko, Feeney, Schenker, Kocon, Zhang, Zhu, Lei, Singh, Kondo, Cleary, Moehler, CheckMate (bib3) 2021; 384 Goenka, Scholz, Sindhava, Cancro (bib54) 2014; 25 Helmink, Reddy, Gao, Zhang, Basar, Thakur, Yizhak, Sade-Feldman, Blando, Han, Gopalakrishnan, Xi, Zhao, Amaria, Tawbi, Cogdill, Liu, LeBleu, Kugeratski, Patel, Davies, Hwu, Lee, Gershenwald, Lucci, Arora, Woodman, Keung, Gaudreau, Reuben, Spencer, Burton, Haydu, Lazar, Zapassodi, Hudgens, Ledesma, Ong, Bailey, Warren, Rao, Krijgsman, Rozeman, Peeper, Blank, Schumacher, Butterfield, Zelazowska, McBride, Kalluri, Allison, Petitprez, Fridman, Sautes-Fridman, Hacohen, Rezvani, Sharma, Tetzlaff, Wang, Wargo (bib17) 2020; 577 Nalio Ramos, Missolo-Koussou, Gerber-Ferder, Bromley, Bugatti, Nunez, Tosello Boari, Richer, Menger, Denizeau, Sedlik, Caudana, Kotsias, Niborski, Viel, Bohec, Lameiras, Baulande, Lesage, Nicolas, Meseure, Vincent-Salomon, Reyal, Dutertre, Ginhoux, Vimeux, Donnadieu, Buttard, Galon, Zelenay, Vermi, Guermonprez, Piaggio, Helft (bib64) 2022; 185 Lu, Zheng, Liu, Wang, Zhang, Wang, Wang, Huang, Mao, Lei, Wang, Sun, He (bib70) 2021; 11 Hu, Zhang, Xia, Yan, Zhu, Sun, Sun, Li, Li, Wang, Han, Zhang, Bian, Yu, Chen, Fan, Ma, Jiang, Wang, Zhang (bib66) 2023; 15 Anders, Pyl, Huber (bib40) 2015; 31 Zhang, Peng, Luo, Zhang, Pu, Chen, Guo, Yao, Shao, Fan, Cui, Xi, Sun, Niu, Zhao, Chen, Wang, Liu, Yang, Wang, Zhong, Tan, Wang, Wu, Lin (bib20) 2021; 12 Huang, Wang, Rubelt, Scriba, Davis (bib43) 2020; 38 Kim, Langmead, Salzberg (bib39) 2015; 12 Maier, Leader, Chen, Tung, Chang, LeBerichel, Chudnovskiy, Maskey, Walker, Finnigan, Kirkling, Reizis, Ghosh, D'Amore, Bhardwaj, Rothlin, Wolf, Flores, Marron, Rahman, Kenigsberg, Brown, Merad (bib61) 2020; 580 Fang, Jin, Zhou, Hong, Ma, Zhang, Su, Chen, Yang, Xu, Liao, He, Zhao, Huang, Gao, Zhang (bib30) 2021; 20 Ullah, Mackay (bib55) 2023 Hellmann, Ciuleanu, Pluzanski, Lee, Otterson, Audigier-Valette, Minenza, Linardou, Burgers, Salman, Borghaei, Ramalingam, Brahmer, Reck, O'Byrne, Geese, Green, Chang, Szustakowski, Bhagavatheeswaran, Healey, Fu, Nathan, Paz-Ares (bib28) 2018; 378 Gerard, Delyon, Wicky, Homicsko, Cuendet, Michielin (bib13) 2021; 101 Z. Liu, Y. Zhang, N. Ma, Y. Yang, Y. Ma, F. Wang, Y. Wang, J. Wei, H. Chen, A. Tartarone, J.B. Velotta, F. Dayyani, E. Gabriel, C.J. Wakefield, B. Kidane, C. Carbonelli, L. L 10.1016/j.canlet.2024.216951_bib24 Klichinsky (10.1016/j.canlet.2024.216951_bib76) 2020; 38 Smillie (10.1016/j.canlet.2024.216951_bib47) 2019; 178 Lu (10.1016/j.canlet.2024.216951_bib77) 2020; 180 Rastogi (10.1016/j.canlet.2024.216951_bib75) 2022; 13 Liu (10.1016/j.canlet.2024.216951_bib48) 2022; 3 Sattiraju (10.1016/j.canlet.2024.216951_bib36) 2023; 56 10.1016/j.canlet.2024.216951_bib26 Zhang (10.1016/j.canlet.2024.216951_bib46) 2022; 10 Abnet (10.1016/j.canlet.2024.216951_bib2) 2018; 154 Liu (10.1016/j.canlet.2024.216951_bib9) 2023; 41 Xue (10.1016/j.canlet.2024.216951_bib67) 2022; 612 Laughney (10.1016/j.canlet.2024.216951_bib35) 2020; 26 Huang (10.1016/j.canlet.2024.216951_bib43) 2020; 38 Nalio Ramos (10.1016/j.canlet.2024.216951_bib64) 2022; 185 Liu (10.1016/j.canlet.2024.216951_bib11) 2022; 3 Zhang (10.1016/j.canlet.2024.216951_bib82) 2023; 8 Jia (10.1016/j.canlet.2024.216951_bib21) 2023; 10 Feig (10.1016/j.canlet.2024.216951_bib19) 2013; 110 Fang (10.1016/j.canlet.2024.216951_bib68) 2022; 13 Goenka (10.1016/j.canlet.2024.216951_bib54) 2014; 25 Luoma (10.1016/j.canlet.2024.216951_bib8) 2022; 185 Ly (10.1016/j.canlet.2024.216951_bib51) 2022; 14 Fridman (10.1016/j.canlet.2024.216951_bib12) 2017; 14 Anders (10.1016/j.canlet.2024.216951_bib40) 2015; 31 Kruse (10.1016/j.canlet.2024.216951_bib60) 2023; 618 Fang (10.1016/j.canlet.2024.216951_bib30) 2021; 20 Gerard (10.1016/j.canlet.2024.216951_bib13) 2021; 101 Fan (10.1016/j.canlet.2024.216951_bib63) 2023; 83 Fang (10.1016/j.canlet.2024.216951_bib72) 2021; 15 Wen (10.1016/j.canlet.2024.216951_bib22) 2022; 86 Cortes (10.1016/j.canlet.2024.216951_bib56) 2004; 199 Lu (10.1016/j.canlet.2024.216951_bib70) 2021; 11 Ge (10.1016/j.canlet.2024.216951_bib32) 2024; 34 Kim (10.1016/j.canlet.2024.216951_bib39) 2015; 12 Bianchi (10.1016/j.canlet.2024.216951_bib81) 2023; 13 10.1016/j.canlet.2024.216951_bib80 Helmink (10.1016/j.canlet.2024.216951_bib17) 2020; 577 Hellmann (10.1016/j.canlet.2024.216951_bib28) 2018; 378 Westcott (10.1016/j.canlet.2024.216951_bib29) 2023; 55 Wang (10.1016/j.canlet.2024.216951_bib74) 2020; 13 Zhang (10.1016/j.canlet.2024.216951_bib25) 2023; 90 Zhang (10.1016/j.canlet.2024.216951_bib42) 2018; 564 Shang (10.1016/j.canlet.2024.216951_bib6) 2021; 32 Oliveira (10.1016/j.canlet.2024.216951_bib10) 2023; 23 Chen (10.1016/j.canlet.2024.216951_bib33) 2023; 41 Jaiswal (10.1016/j.canlet.2024.216951_bib78) 2022; 40 Omoto (10.1016/j.canlet.2024.216951_bib62) 2006; 177 Messina (10.1016/j.canlet.2024.216951_bib57) 2012; 2 Xue (10.1016/j.canlet.2024.216951_bib18) 2022; 612 Cui (10.1016/j.canlet.2024.216951_bib69) 2021; 184 Meylan (10.1016/j.canlet.2024.216951_bib38) 2022; 55 Escobar (10.1016/j.canlet.2024.216951_bib50) 2023; 41 Gupta (10.1016/j.canlet.2024.216951_bib44) 2015; 31 Bod (10.1016/j.canlet.2024.216951_bib59) 2023; 619 Liu (10.1016/j.canlet.2024.216951_bib5) 2022; 10 Hao (10.1016/j.canlet.2024.216951_bib37) 2022; 12 Cheng (10.1016/j.canlet.2024.216951_bib45) 2021; 184 Gungabeesoon (10.1016/j.canlet.2024.216951_bib65) 2023; 186 Goto (10.1016/j.canlet.2024.216951_bib34) 2024; 627 Guo (10.1016/j.canlet.2024.216951_bib52) 2018; 24 Kojima (10.1016/j.canlet.2024.216951_bib4) 2020; 38 Yang (10.1016/j.canlet.2024.216951_bib23) 2023; 8 Hu (10.1016/j.canlet.2024.216951_bib66) 2023; 15 Liu (10.1016/j.canlet.2024.216951_bib27) 2022; 10 Maier (10.1016/j.canlet.2024.216951_bib61) 2020; 580 Ullah (10.1016/j.canlet.2024.216951_bib55) 2023 Oliveira (10.1016/j.canlet.2024.216951_bib14) 2023; 8 Zhang (10.1016/j.canlet.2024.216951_bib20) 2021; 12 Patil (10.1016/j.canlet.2024.216951_bib16) 2022; 40 Kelly (10.1016/j.canlet.2024.216951_bib3) 2021; 384 Bassez (10.1016/j.canlet.2024.216951_bib7) 2021; 27 de Vries (10.1016/j.canlet.2024.216951_bib79) 2023; 613 Chiou (10.1016/j.canlet.2024.216951_bib53) 2021; 54 Borcherding (10.1016/j.canlet.2024.216951_bib41) 2020; 9 Liu (10.1016/j.canlet.2024.216951_bib73) 2023; 186 Wolf (10.1016/j.canlet.2024.216951_bib31) 2019; 179 Schumacher (10.1016/j.canlet.2024.216951_bib58) 2022; 375 Sade-Feldman (10.1016/j.canlet.2024.216951_bib15) 2018; 175 Sung (10.1016/j.canlet.2024.216951_bib1) 2021; 71 Ren (10.1016/j.canlet.2024.216951_bib49) 2021; 39 Liu (10.1016/j.canlet.2024.216951_bib71) 2022; 7 |
| References_xml | – volume: 2 start-page: 765 year: 2012 ident: bib57 article-title: 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy? publication-title: Sci. Rep. – volume: 55 year: 2022 ident: bib38 article-title: Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer publication-title: Immunity – volume: 154 start-page: 360 year: 2018 end-page: 373 ident: bib2 article-title: Epidemiology of esophageal squamous cell carcinoma publication-title: Gastroenterology – volume: 564 start-page: 268 year: 2018 end-page: 272 ident: bib42 article-title: Lineage tracking reveals dynamic relationships of T cells in colorectal cancer publication-title: Nature – volume: 41 year: 2023 ident: bib33 article-title: An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma publication-title: Cancer Cell – volume: 184 year: 2021 ident: bib69 article-title: Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses publication-title: Cell – volume: 31 start-page: 3356 year: 2015 end-page: 3358 ident: bib44 article-title: Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data publication-title: Bioinformatics – volume: 24 start-page: 978 year: 2018 end-page: 985 ident: bib52 article-title: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing publication-title: Nat. Med. – volume: 40 year: 2022 ident: bib16 article-title: Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer publication-title: Cancer Cell – volume: 185 year: 2022 ident: bib8 article-title: Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy publication-title: Cell – volume: 101 year: 2021 ident: bib13 article-title: Turning tumors from cold to inflamed to improve immunotherapy response publication-title: Cancer Treat Rev. – volume: 55 start-page: 1686 year: 2023 end-page: 1695 ident: bib29 article-title: Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity publication-title: Nat. Genet. – volume: 86 year: 2022 ident: bib22 article-title: Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma publication-title: EBioMedicine – volume: 186 year: 2023 ident: bib65 article-title: A neutrophil response linked to tumor control in immunotherapy publication-title: Cell – volume: 177 start-page: 8315 year: 2006 end-page: 8319 ident: bib62 article-title: Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment publication-title: J. Immunol. – volume: 8 year: 2023 ident: bib14 article-title: Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer publication-title: Sci Immunol – volume: 8 start-page: 298 year: 2023 ident: bib23 article-title: Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics publication-title: Signal Transduct. Targeted Ther. – volume: 175 year: 2018 ident: bib15 article-title: Defining T cell states associated with response to checkpoint immunotherapy in melanoma publication-title: Cell – start-page: 15 year: 2023 ident: bib55 article-title: The BAFF-APRIL system in cancer publication-title: Cancers – volume: 199 start-page: 209 year: 2004 end-page: 219 ident: bib56 article-title: Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity publication-title: J. Exp. Med. – volume: 110 start-page: 20212 year: 2013 end-page: 20217 ident: bib19 article-title: Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 12 start-page: 357 year: 2015 end-page: 360 ident: bib39 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods – volume: 375 year: 2022 ident: bib58 article-title: Tertiary lymphoid structures in cancer publication-title: Science – volume: 12 start-page: 2626 year: 2022 end-page: 2645 ident: bib37 article-title: The single-cell immunogenomic landscape of B and plasma cells in early-stage lung adenocarcinoma publication-title: Cancer Discov. – volume: 23 start-page: 295 year: 2023 end-page: 316 ident: bib10 article-title: Dynamics and specificities of T cells in cancer immunotherapy publication-title: Nat. Rev. Cancer – volume: 83 start-page: 2690 year: 2023 end-page: 2703 ident: bib63 article-title: Elevated mast cell abundance is associated with enrichment of CCR2+Cytotoxic T cells and favorable prognosis in lung adenocarcinoma publication-title: Cancer Res. – volume: 613 start-page: 743 year: 2023 end-page: 750 ident: bib79 article-title: Gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects publication-title: Nature – reference: C.X. Wang, X.C. Zheng, J.L. Zhang, X.Y. Jiang, J. Wang, Y.W. Li, X.A. Li, G.H. Shen, J.Y. Peng, P.X. Zheng, Y.Q. Gu, J.J. Chen, M.B. Lin, C.W. Deng, H. Gao, Z.G. Lu, Y. Zhao, M. Luo, CD300ld on neutrophils is required for tumour-driven immune suppression, Nature, 621 (2023) 830-+. – volume: 12 start-page: 5291 year: 2021 ident: bib20 article-title: Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis publication-title: Nat. Commun. – volume: 27 start-page: 820 year: 2021 end-page: 832 ident: bib7 article-title: A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer publication-title: Nat. Med. – volume: 179 year: 2019 ident: bib31 article-title: UVB-induced tumor heterogeneity diminishes immune response in melanoma publication-title: Cell – volume: 180 year: 2020 ident: bib77 article-title: Complement signals determine opposite effects of B cells in chemotherapy-induced immunity publication-title: Cell – volume: 14 year: 2022 ident: bib51 article-title: Tumor-associated regulatory T cell expression of LAIR2 is prognostic in lung adenocarcinoma publication-title: Cancers – volume: 15 start-page: 14 year: 2023 ident: bib66 article-title: Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing publication-title: Genome Med. – volume: 577 start-page: 549 year: 2020 end-page: 555 ident: bib17 article-title: B cells and tertiary lymphoid structures promote immunotherapy response publication-title: Nature – volume: 41 year: 2023 ident: bib50 article-title: Tumor immunogenicity dictates reliance on TCF1 in CD8(+) T cells for response to immunotherapy publication-title: Cancer Cell – reference: Z. Liu, Y. Zhang, N. Ma, Y. Yang, Y. Ma, F. Wang, Y. Wang, J. Wei, H. Chen, A. Tartarone, J.B. Velotta, F. Dayyani, E. Gabriel, C.J. Wakefield, B. Kidane, C. Carbonelli, L. Long, Z. Liu, J. Su, Z. Li, Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma, Cancer Cell, 41 (2023) 1852-+. – volume: 580 year: 2020 ident: bib61 article-title: A conserved dendritic-cell regulatory program limits antitumour immunity publication-title: Nature – volume: 612 start-page: 141 year: 2022 end-page: 147 ident: bib18 article-title: Liver tumour immune microenvironment subtypes and neutrophil heterogeneity publication-title: Nature – volume: 10 year: 2022 ident: bib27 article-title: Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma publication-title: J Immunother Cancer – volume: 26 start-page: 259 year: 2020 end-page: 269 ident: bib35 article-title: Regenerative lineages and immune-mediated pruning in lung cancer metastasis publication-title: Nat. Med. – reference: J. Yin, J. Yuan, Y. Li, Y. Fang, R. Wang, H. Jiao, H. Tang, S. Zhang, S. Lin, F. Su, J. Gu, T. Jiang, D. Lin, Z. Huang, C. Du, K. Wu, L. Tan, Q. Zhou, Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial, Nat. Med. 29 (2023) 2068-+. – volume: 13 year: 2022 ident: bib68 article-title: No NETs no TIME: crosstalk between neutrophil extracellular traps and the tumor immune microenvironment publication-title: Front. Immunol. – volume: 618 start-page: 1033 year: 2023 end-page: 1040 ident: bib60 article-title: CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours publication-title: Nature – volume: 13 year: 2022 ident: bib75 article-title: Role of B cells as antigen presenting cells publication-title: Front. Immunol. – volume: 612 year: 2022 ident: bib67 article-title: Liver tumour immune microenvironment subtypes and neutrophil heterogeneity publication-title: Nature – volume: 8 start-page: 97 year: 2023 ident: bib82 article-title: PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway publication-title: Signal Transduct. Targeted Ther. – volume: 184 year: 2021 ident: bib45 article-title: A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells publication-title: Cell – volume: 10 year: 2022 ident: bib46 article-title: A signature for pan-cancer prognosis based on neutrophil extracellular traps publication-title: J Immunother Cancer – volume: 15 start-page: 3125 year: 2021 end-page: 3146 ident: bib72 article-title: LAMC1 upregulation via TGFbeta induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-kappaB-CXCL1-STAT3 publication-title: Mol. Oncol. – volume: 378 start-page: 2093 year: 2018 end-page: 2104 ident: bib28 article-title: Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden publication-title: N. Engl. J. Med. – volume: 627 start-page: 636 year: 2024 end-page: 645 ident: bib34 article-title: SOX17 enables immune evasion of early colorectal adenomas and cancers publication-title: Nature – volume: 10 year: 2022 ident: bib5 article-title: Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma publication-title: Journal for Immunotherapy of Cancer – volume: 34 start-page: 58 year: 2024 end-page: 75 ident: bib32 article-title: ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer publication-title: Cell Res. – volume: 178 year: 2019 ident: bib47 article-title: Intra- and inter-cellular rewiring of the human colon during ulcerative colitis publication-title: Cell – volume: 39 start-page: 583 year: 2021 end-page: 609 ident: bib49 article-title: Insights gained from single-cell analysis of immune cells in the tumor microenvironment publication-title: Annu. Rev. Immunol. – volume: 9 start-page: 47 year: 2020 ident: bib41 article-title: scRepertoire: an R-based toolkit for single-cell immune receptor analysis publication-title: F1000Res – volume: 186 year: 2023 ident: bib73 article-title: A tissue injury sensing and repair pathway distinct from host pathogen defense publication-title: Cell – volume: 41 year: 2023 ident: bib9 article-title: Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma publication-title: Cancer Cell – volume: 31 start-page: 166 year: 2015 end-page: 169 ident: bib40 article-title: HTSeq--a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics – volume: 38 start-page: 1194 year: 2020 end-page: 1202 ident: bib43 article-title: Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening publication-title: Nat. Biotechnol. – volume: 13 start-page: 107 year: 2020 ident: bib74 article-title: Dendritic cell biology and its role in tumor immunotherapy publication-title: J. Hematol. Oncol. – volume: 56 year: 2023 ident: bib36 article-title: Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression publication-title: Immunity – volume: 71 start-page: 209 year: 2021 end-page: 249 ident: bib1 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA A Cancer J. Clin. – volume: 185 year: 2022 ident: bib64 article-title: Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer publication-title: Cell – volume: 90 year: 2023 ident: bib25 article-title: Multi-omics analysis uncovers tumor ecosystem dynamics during neoadjuvant toripalimab plus nab-paclitaxel and S-1 for esophageal squamous cell carcinoma: a single-center, open-label, single-arm phase 2 trial publication-title: EBioMedicine – volume: 3 start-page: 1123 year: 2022 end-page: 1136 ident: bib48 article-title: Single-cell meta-analyses reveal responses of tumor-reactive CXCL13(+) T cells to immune-checkpoint blockade publication-title: Nat. Can. (Ott.) – volume: 11 year: 2021 ident: bib70 article-title: S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis publication-title: Clin. Transl. Med. – volume: 13 start-page: 1428 year: 2023 end-page: 1453 ident: bib81 article-title: Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer publication-title: Cancer Discov. – volume: 38 start-page: 4138 year: 2020 end-page: 4148 ident: bib4 article-title: Randomized phase III KEYNOTE-181 study of pembrolizumab versus chemotherapy in advanced esophageal cancer publication-title: J. Clin. Oncol. – volume: 3 start-page: 108 year: 2022 end-page: 121 ident: bib11 article-title: Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer publication-title: Nat. Can. (Ott.) – volume: 20 start-page: 37 year: 2021 ident: bib30 article-title: Intratumoral heterogeneity as a predictive biomarker in anti-PD-(L)1 therapies for non-small cell lung cancer publication-title: Mol. Cancer – volume: 54 year: 2021 ident: bib53 article-title: Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery publication-title: Immunity – volume: 40 start-page: 524 year: 2022 end-page: 544 e525 ident: bib78 article-title: An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes publication-title: Cancer Cell – volume: 25 start-page: 107 year: 2014 end-page: 113 ident: bib54 article-title: New roles for the BLyS/BAFF family in antigen-experienced B cell niches publication-title: Cytokine Growth Factor Rev. – volume: 7 start-page: 368 year: 2022 ident: bib71 article-title: S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma publication-title: Signal Transduct. Targeted Ther. – volume: 14 start-page: 717 year: 2017 end-page: 734 ident: bib12 article-title: The immune contexture in cancer prognosis and treatment publication-title: Nat. Rev. Clin. Oncol. – volume: 619 start-page: 348 year: 2023 end-page: 356 ident: bib59 article-title: B-cell-specific checkpoint molecules that regulate anti-tumour immunity publication-title: Nature – volume: 384 start-page: 1191 year: 2021 end-page: 1203 ident: bib3 article-title: Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer publication-title: N. Engl. J. Med. – volume: 32 start-page: S1428 year: 2021 end-page: S1429 ident: bib6 article-title: Safety and efficacy of pembrolizumab combined with paclitaxel and cisplatin as a neoadjuvant treatment for locally advanced resectable (stage III) esophageal squamous cell carcinoma (Keystone-001): interim analysis of a prospective, single-arm, single-center, phase II trial publication-title: Ann. Oncol. – volume: 10 year: 2023 ident: bib21 article-title: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in esophageal squamous cell carcinoma publication-title: Adv. Sci. – volume: 38 start-page: 947 year: 2020 end-page: 953 ident: bib76 article-title: Human chimeric antigen receptor macrophages for cancer immunotherapy publication-title: Nat. Biotechnol. – volume: 13 start-page: 1428 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib81 article-title: Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-22-1046 – volume: 384 start-page: 1191 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib3 article-title: Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2032125 – volume: 199 start-page: 209 year: 2004 ident: 10.1016/j.canlet.2024.216951_bib56 article-title: Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity publication-title: J. Exp. Med. doi: 10.1084/jem.20031571 – volume: 41 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib9 article-title: Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma publication-title: Cancer Cell doi: 10.1016/j.ccell.2023.09.011 – volume: 90 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib25 article-title: Multi-omics analysis uncovers tumor ecosystem dynamics during neoadjuvant toripalimab plus nab-paclitaxel and S-1 for esophageal squamous cell carcinoma: a single-center, open-label, single-arm phase 2 trial publication-title: EBioMedicine doi: 10.1016/j.ebiom.2023.104515 – volume: 14 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib51 article-title: Tumor-associated regulatory T cell expression of LAIR2 is prognostic in lung adenocarcinoma publication-title: Cancers – volume: 26 start-page: 259 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib35 article-title: Regenerative lineages and immune-mediated pruning in lung cancer metastasis publication-title: Nat. Med. doi: 10.1038/s41591-019-0750-6 – volume: 32 start-page: S1428 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib6 publication-title: Ann. Oncol. doi: 10.1016/j.annonc.2021.10.218 – volume: 3 start-page: 108 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib11 article-title: Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer publication-title: Nat. Can. (Ott.) doi: 10.1038/s43018-021-00292-8 – volume: 375 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib58 article-title: Tertiary lymphoid structures in cancer publication-title: Science doi: 10.1126/science.abf9419 – volume: 577 start-page: 549 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib17 article-title: B cells and tertiary lymphoid structures promote immunotherapy response publication-title: Nature doi: 10.1038/s41586-019-1922-8 – volume: 618 start-page: 1033 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib60 article-title: CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours publication-title: Nature doi: 10.1038/s41586-023-06199-x – volume: 580 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib61 article-title: A conserved dendritic-cell regulatory program limits antitumour immunity publication-title: Nature doi: 10.1038/s41586-020-2134-y – volume: 154 start-page: 360 year: 2018 ident: 10.1016/j.canlet.2024.216951_bib2 article-title: Epidemiology of esophageal squamous cell carcinoma publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.08.023 – volume: 612 start-page: 141 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib18 article-title: Liver tumour immune microenvironment subtypes and neutrophil heterogeneity publication-title: Nature doi: 10.1038/s41586-022-05400-x – volume: 10 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib46 article-title: A signature for pan-cancer prognosis based on neutrophil extracellular traps publication-title: J Immunother Cancer doi: 10.1136/jitc-2021-004210 – volume: 184 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib45 article-title: A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells publication-title: Cell doi: 10.1016/j.cell.2021.01.010 – volume: 23 start-page: 295 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib10 article-title: Dynamics and specificities of T cells in cancer immunotherapy publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-023-00560-y – volume: 54 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib53 article-title: Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery publication-title: Immunity doi: 10.1016/j.immuni.2021.02.014 – volume: 15 start-page: 14 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib66 article-title: Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing publication-title: Genome Med. doi: 10.1186/s13073-023-01164-9 – volume: 38 start-page: 4138 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib4 article-title: Randomized phase III KEYNOTE-181 study of pembrolizumab versus chemotherapy in advanced esophageal cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.20.01888 – volume: 25 start-page: 107 year: 2014 ident: 10.1016/j.canlet.2024.216951_bib54 article-title: New roles for the BLyS/BAFF family in antigen-experienced B cell niches publication-title: Cytokine Growth Factor Rev. doi: 10.1016/j.cytogfr.2014.01.001 – volume: 110 start-page: 20212 year: 2013 ident: 10.1016/j.canlet.2024.216951_bib19 article-title: Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1320318110 – volume: 34 start-page: 58 year: 2024 ident: 10.1016/j.canlet.2024.216951_bib32 article-title: ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer publication-title: Cell Res. doi: 10.1038/s41422-023-00909-w – volume: 564 start-page: 268 year: 2018 ident: 10.1016/j.canlet.2024.216951_bib42 article-title: Lineage tracking reveals dynamic relationships of T cells in colorectal cancer publication-title: Nature doi: 10.1038/s41586-018-0694-x – volume: 13 start-page: 107 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib74 article-title: Dendritic cell biology and its role in tumor immunotherapy publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-020-00939-6 – volume: 8 start-page: 97 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib82 article-title: PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway publication-title: Signal Transduct. Targeted Ther. doi: 10.1038/s41392-023-01337-3 – volume: 39 start-page: 583 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib49 article-title: Insights gained from single-cell analysis of immune cells in the tumor microenvironment publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-110519-071134 – volume: 55 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib38 article-title: Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer publication-title: Immunity doi: 10.1016/j.immuni.2022.02.001 – volume: 56 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib36 article-title: Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression publication-title: Immunity doi: 10.1016/j.immuni.2023.06.017 – volume: 12 start-page: 357 year: 2015 ident: 10.1016/j.canlet.2024.216951_bib39 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 – volume: 613 start-page: 743 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib79 article-title: Gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects publication-title: Nature doi: 10.1038/s41586-022-05593-1 – volume: 2 start-page: 765 year: 2012 ident: 10.1016/j.canlet.2024.216951_bib57 article-title: 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy? publication-title: Sci. Rep. doi: 10.1038/srep00765 – volume: 71 start-page: 209 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib1 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA A Cancer J. Clin. doi: 10.3322/caac.21660 – volume: 11 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib70 article-title: S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis publication-title: Clin. Transl. Med. doi: 10.1002/ctm2.459 – volume: 12 start-page: 5291 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib20 article-title: Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis publication-title: Nat. Commun. doi: 10.1038/s41467-021-25539-x – volume: 20 start-page: 37 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib30 article-title: Intratumoral heterogeneity as a predictive biomarker in anti-PD-(L)1 therapies for non-small cell lung cancer publication-title: Mol. Cancer doi: 10.1186/s12943-021-01331-9 – volume: 185 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib8 article-title: Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy publication-title: Cell doi: 10.1016/j.cell.2022.06.018 – volume: 612 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib67 article-title: Liver tumour immune microenvironment subtypes and neutrophil heterogeneity publication-title: Nature doi: 10.1038/s41586-022-05400-x – volume: 55 start-page: 1686 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib29 article-title: Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity publication-title: Nat. Genet. doi: 10.1038/s41588-023-01499-4 – volume: 9 start-page: 47 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib41 article-title: scRepertoire: an R-based toolkit for single-cell immune receptor analysis publication-title: F1000Res doi: 10.12688/f1000research.22139.1 – volume: 185 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib64 article-title: Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer publication-title: Cell doi: 10.1016/j.cell.2022.02.021 – start-page: 15 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib55 article-title: The BAFF-APRIL system in cancer publication-title: Cancers – volume: 13 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib68 article-title: No NETs no TIME: crosstalk between neutrophil extracellular traps and the tumor immune microenvironment publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.1075260 – volume: 175 year: 2018 ident: 10.1016/j.canlet.2024.216951_bib15 article-title: Defining T cell states associated with response to checkpoint immunotherapy in melanoma publication-title: Cell doi: 10.1016/j.cell.2018.10.038 – volume: 41 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib33 article-title: An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma publication-title: Cancer Cell doi: 10.1016/j.ccell.2023.03.016 – volume: 27 start-page: 820 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib7 article-title: A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer publication-title: Nat. Med. doi: 10.1038/s41591-021-01323-8 – volume: 83 start-page: 2690 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib63 article-title: Elevated mast cell abundance is associated with enrichment of CCR2+Cytotoxic T cells and favorable prognosis in lung adenocarcinoma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-22-3140 – volume: 8 start-page: 298 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib23 article-title: Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics publication-title: Signal Transduct. Targeted Ther. doi: 10.1038/s41392-023-01518-0 – volume: 40 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib16 article-title: Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer publication-title: Cancer Cell doi: 10.1016/j.ccell.2022.02.002 – volume: 15 start-page: 3125 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib72 article-title: LAMC1 upregulation via TGFbeta induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-kappaB-CXCL1-STAT3 publication-title: Mol. Oncol. doi: 10.1002/1878-0261.13053 – ident: 10.1016/j.canlet.2024.216951_bib80 doi: 10.1038/s41586-023-06511-9 – ident: 10.1016/j.canlet.2024.216951_bib24 doi: 10.1038/s41591-023-02469-3 – volume: 38 start-page: 1194 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib43 article-title: Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0505-4 – volume: 3 start-page: 1123 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib48 article-title: Single-cell meta-analyses reveal responses of tumor-reactive CXCL13(+) T cells to immune-checkpoint blockade publication-title: Nat. Can. (Ott.) doi: 10.1038/s43018-022-00433-7 – volume: 10 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib5 article-title: Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma publication-title: Journal for Immunotherapy of Cancer doi: 10.1136/jitc-2021-004291 – volume: 41 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib50 article-title: Tumor immunogenicity dictates reliance on TCF1 in CD8(+) T cells for response to immunotherapy publication-title: Cancer Cell doi: 10.1016/j.ccell.2023.08.001 – volume: 627 start-page: 636 year: 2024 ident: 10.1016/j.canlet.2024.216951_bib34 article-title: SOX17 enables immune evasion of early colorectal adenomas and cancers publication-title: Nature doi: 10.1038/s41586-024-07135-3 – volume: 7 start-page: 368 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib71 article-title: S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma publication-title: Signal Transduct. Targeted Ther. doi: 10.1038/s41392-022-01196-4 – volume: 180 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib77 article-title: Complement signals determine opposite effects of B cells in chemotherapy-induced immunity publication-title: Cell doi: 10.1016/j.cell.2020.02.015 – volume: 10 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib21 article-title: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in esophageal squamous cell carcinoma publication-title: Adv. Sci. doi: 10.1002/advs.202204565 – volume: 378 start-page: 2093 year: 2018 ident: 10.1016/j.canlet.2024.216951_bib28 article-title: Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1801946 – volume: 186 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib65 article-title: A neutrophil response linked to tumor control in immunotherapy publication-title: Cell doi: 10.1016/j.cell.2023.02.032 – volume: 177 start-page: 8315 year: 2006 ident: 10.1016/j.canlet.2024.216951_bib62 article-title: Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment publication-title: J. Immunol. doi: 10.4049/jimmunol.177.12.8315 – volume: 13 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib75 article-title: Role of B cells as antigen presenting cells publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.954936 – volume: 14 start-page: 717 year: 2017 ident: 10.1016/j.canlet.2024.216951_bib12 article-title: The immune contexture in cancer prognosis and treatment publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2017.101 – volume: 186 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib73 article-title: A tissue injury sensing and repair pathway distinct from host pathogen defense publication-title: Cell doi: 10.1016/j.cell.2023.03.031 – volume: 12 start-page: 2626 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib37 article-title: The single-cell immunogenomic landscape of B and plasma cells in early-stage lung adenocarcinoma publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-21-1658 – volume: 40 start-page: 524 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib78 article-title: An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes publication-title: Cancer Cell doi: 10.1016/j.ccell.2022.04.005 – volume: 86 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib22 article-title: Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma publication-title: EBioMedicine doi: 10.1016/j.ebiom.2022.104371 – volume: 24 start-page: 978 year: 2018 ident: 10.1016/j.canlet.2024.216951_bib52 article-title: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing publication-title: Nat. Med. doi: 10.1038/s41591-018-0045-3 – volume: 619 start-page: 348 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib59 article-title: B-cell-specific checkpoint molecules that regulate anti-tumour immunity publication-title: Nature doi: 10.1038/s41586-023-06231-0 – volume: 38 start-page: 947 year: 2020 ident: 10.1016/j.canlet.2024.216951_bib76 article-title: Human chimeric antigen receptor macrophages for cancer immunotherapy publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0462-y – volume: 8 year: 2023 ident: 10.1016/j.canlet.2024.216951_bib14 article-title: Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer publication-title: Sci Immunol doi: 10.1126/sciimmunol.adf4968 – volume: 179 year: 2019 ident: 10.1016/j.canlet.2024.216951_bib31 article-title: UVB-induced tumor heterogeneity diminishes immune response in melanoma publication-title: Cell doi: 10.1016/j.cell.2019.08.032 – volume: 31 start-page: 3356 year: 2015 ident: 10.1016/j.canlet.2024.216951_bib44 article-title: Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv359 – volume: 178 year: 2019 ident: 10.1016/j.canlet.2024.216951_bib47 article-title: Intra- and inter-cellular rewiring of the human colon during ulcerative colitis publication-title: Cell doi: 10.1016/j.cell.2019.06.029 – volume: 184 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib69 article-title: Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses publication-title: Cell doi: 10.1016/j.cell.2021.11.007 – ident: 10.1016/j.canlet.2024.216951_bib26 doi: 10.1016/j.ccell.2023.09.011 – volume: 10 year: 2022 ident: 10.1016/j.canlet.2024.216951_bib27 article-title: Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma publication-title: J Immunother Cancer doi: 10.1136/jitc-2021-004291 – volume: 101 year: 2021 ident: 10.1016/j.canlet.2024.216951_bib13 article-title: Turning tumors from cold to inflamed to improve immunotherapy response publication-title: Cancer Treat Rev. doi: 10.1016/j.ctrv.2021.102227 – volume: 31 start-page: 166 year: 2015 ident: 10.1016/j.canlet.2024.216951_bib40 article-title: HTSeq--a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu638 |
| SSID | ssj0005475 |
| Score | 2.4816089 |
| Snippet | Neoadjuvant immunotherapy represents promising strategy in the treatment of esophageal squamous cell carcinoma (ESCC). However, the mechanisms underlying its... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 216951 |
| SubjectTerms | Aged Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemokine CXCL13 - genetics Chemokine CXCL13 - metabolism Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - immunology Esophageal Squamous Cell Carcinoma - pathology Esophageal Squamous Cell Carcinoma - therapy Female Humans Immunotherapy - methods Leukocyte Common Antigens - genetics Leukocyte Common Antigens - metabolism Male Memory T Cells - immunology Memory T Cells - metabolism Middle Aged Neoadjuvant Therapy - methods Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism Receptors, CXCR5 - genetics Receptors, CXCR5 - metabolism Single-Cell Analysis - methods T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Tumor Microenvironment - immunology |
| Title | The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0304383524003446 https://dx.doi.org/10.1016/j.canlet.2024.216951 https://www.ncbi.nlm.nih.gov/pubmed/38734159 https://www.proquest.com/docview/3053981420 |
| Volume | 593 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQlapeKvqiy0uu1GvYjV9rHxECbUFwaZG4WY4zloIgS8vugQuX_vHOxMmqHBCIYyxbdmbs8TeeF2PfrU0QU8KTBqlCBUVPCgeGDI6EDmpna0PRyGfnZnahTi715Ro7HGJhyK2yl_1ZpnfSum8Z99Qc3zbN-CcZ9SQBCNXlraO025S9Dvf0_sN_bh6qS7ZLnQvqPYTPdT5euHqkDmqJQu2L0jhdPnU9PQU_u2voeIO97_EjP8hL_MDWoP3I3p71FvJP7C_ynZP-fw2cHuV5QwEgc0rFetNE3kX2ks8T74qD8xbmob5aIpxe9D1zQNY9R4Kg0gw1R67erFqblgMVPkAphKu4-70M9HSQZ4pUlginCZ_ZxfHRr8NZ0RdaKCLe34tCR1FVqLqgKlKakKwTMUGaWpeCC4gHJVhjTQlCRCEdWA0AxjilQi1rCVF-YevtvIWvjGs5lTJqB6IGJYOycRKqpKMkqztirRGTA3197LOQUzGMaz-4m135zBVPXPGZKyNWrEbd5iwcz_TXA-v8EGGKMtHjNfHMuOlq3KNd-IKR34Yd4vGAEtkDsnB551GgSmdLJSYjtpm3zuofpJ0iitBu69XzbrN39JUdiHfY-uLPEnYRJi2qve4c7LE3Bz9OZ-f_AASlE5k |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELZKKkEviDfhaSSuS7J-xT5WFVVKm1xopd4sr3dW2qrdFJoceuaPM7P2BnGoirh6PbJ3xh5_Y8-Dsc_WNhCbBncaNBUaKHpaODD04EjooHa2NhSNvFia-Zn6dq7Pd9jBEAtDbpVZ9yed3mvr3DLJ3Jxct-3kOz3qSQIQqs9bZx6wXcpOpUZsd__oeL784-mh-ny71L8ggiGCrnfzwh9ABqGhKNQXURqny7tOqLsQaH8SHT5hjzOE5Ptplk_ZDnTP2MNFfiR_zn6h6DldAVwCp3t53lIMyIqysV61kffBveT2xPv64LyDVagvNoio17lnism65cgTtJuh5ijYq21r23Gg2geoiHAWNz82gW4P0kiRKhPhMOEFOzv8enowL3KthSLiEb4udBRVhdYLWiOlCY11IjbQzKxrggsICSVYY00JQkQhHVgNAMY4pUItawlRvmSjbtXBa8a1nEkZtQNRg5JB2TgNVaOjpId3hFtjJgf--pgTkVM9jEs_eJxd-CQVT1LxSSpjVmyprlMijnv660F0fggyRbXo8aS4h262pftrIf4D5adhhXjco8T2gCLc3HjUqdLZUonpmL1KS2f7D9LOEEho9-a_x_3IHs1PFyf-5Gh5_Jbt0ZfkT_yOjdY_N_AeUdO6-pB3xW9jyxZK |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+single+cell+immunogenomic+landscape+after+neoadjuvant+immunotherapy+combined+chemotherapy+in+esophageal+squamous+cell+carcinoma&rft.jtitle=Cancer+letters&rft.au=Wang%2C+Zheyi&rft.au=Zhao%2C+Yue&rft.au=Wo%2C+Yang&rft.au=Peng%2C+Yizhou&rft.date=2024-07-01&rft.pub=Elsevier+B.V&rft.issn=0304-3835&rft.volume=593&rft_id=info:doi/10.1016%2Fj.canlet.2024.216951&rft.externalDocID=S0304383524003446 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3835&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3835&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3835&client=summon |