Multinight "bedside" closed-loop control for patients with type 1 diabetes

• Published in: Diabetes technology & therapeutics Vol. 17; no. 3; p. 203
• Main Authors: Brown, Sue A, Kovatchev, Boris P, Breton, Marc D, Anderson, Stacey M, Keith-Hynes, Patrick, Patek, Stephen D, Jiang, Boyi, Ben Brahim, Najib, Vereshchetin, Paul, Bruttomesso, Daniela, Avogaro, Angelo, Del Favero, Simone, Boscari, Federico, Galasso, Silvia, Visentin, Roberto, Monaro, Marco, Cobelli, Claudio
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Adult; Blood Glucose - metabolism; Blood Glucose Self-Monitoring - methods; Blood Glucose Self-Monitoring - statistics & numerical data; Cross-Over Studies; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Drug Chronotherapy; Fasting - blood; Female; Humans; Hypoglycemic Agents - administration & dosage; Insulin - administration & dosage; Insulin Infusion Systems; Italy; Male; Middle Aged; Time Factors; Treatment Outcome; United States; United States; Italy
• ISSN: 1557-8593
• DOI: 10.1089/dia.2014.0259

Studies of closed-loop control (CLC) systems have improved glucose levels in patients with type 1 diabetes. In this study we test a new CLC concept aiming to "reset" the patient overnight to near-normoglycemia each morning, for several consecutive nights. Ten insulin pump users with type 1 diabetes (mean age, 46.4±8.5 years) were enrolled in a two-center (in the United States and Italy) randomized crossover trial comparing 5 consecutive nights of CLC (23:00-07:00 h) in an outpatient setting versus sensor-augmented insulin pump therapy of the same duration at home. Primary end points included time spent in 80-140 mg/dL as measured by continuous glucose monitoring overnight and fasting blood glucose distribution at 7:00 h. Compared with sensor-augmented pump therapy, CLC improved significantly time spent between 80 and 140 mg/dL (54.5% vs. 32.2%; P<0.001) and between 70 and 180 mg/dL (85.4% vs. 59.1%; P<0.001); CLC reduced the mean glucose level at 07:00 h (119.3 vs. 152.9 mg/dL; P<0.001) and overnight mean glucose level (139.0 vs. 170.3 mg/dL; P<0.001) using a marginally lower amount of insulin (6.1 vs. 6.8 units; P=0.1). Tighter overnight control led to improved daytime control on the next day: the overnight/next-day control correlation was r=0.52, P<0.01. Multinight CLC of insulin delivery (artificial pancreas) results in significant improvement in morning and overnight glucose levels and time in target range, with the potential to improve daytime control when glucose levels were "reset" to near-normoglycemia each morning.