Late Contrast Enhancing Brain Lesions in Proton-Treated Patients With Low-Grade Glioma: Clinical Evidence for Increased Periventricular Sensitivity and Variable RBE

• Published in: International journal of radiation oncology, biology, physics Vol. 107; no. 3; pp. 571 - 578
• Main Authors: Bahn, Emanuel, Bauer, Julia, Harrabi, Semi, Herfarth, Klaus, Debus, Jürgen, Alber, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020
• Subjects: Adolescent; Adult; Brain Neoplasms - pathology; Brain Neoplasms - radiotherapy; Child; Child, Preschool; Female; Glioma - pathology; Glioma - radiotherapy; Humans; Linear Energy Transfer; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Proton Therapy; Relative Biological Effectiveness; Retrospective Studies; Young Adult

Late radiation-induced contrast-enhancing brain lesions (CEBLs) on magnetic resonance imaging (MRI) after proton therapy of brain tumors have been observed to occur frequently in regions of high linear energy transfer (LET) and in proximity to the ventricular system. We analyzed 110 patients with lo...