Selective cytotoxicity of synthesized procyanidin 3-O-Galloylepicatechin-4b,8-3-O-galloylcatechin to human cancer cells

• Published in: Cell cycle (Georgetown, Tex.) Vol. 7; no. 11; pp. 1648 - 1657
• Main Authors: Kim, Min, Wu, Xiaofang, Song, Insun, Fu, Maofu, Chang, Seo-Hee, Lisanti, Michael P., Pestell, Richard G.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.06.2008
• Subjects: Apoptosis - drug effects; Binding; Biology; Bioscience; Blotting, Western; Calcium; Cancer; Catechin - analogs & derivatives; Catechin - chemical synthesis; Catechin - toxicity; Cell; Cell Line, Tumor; Cell Proliferation - drug effects; Cycle; Gene Expression Profiling; Humans; I-kappa B Kinase - metabolism; Landes; Membrane Potential, Mitochondrial - drug effects; Organogenesis; Polymerase Chain Reaction; Proanthocyanidins - chemical synthesis; Proanthocyanidins - toxicity; Proteins; Signal Transduction - physiology

Cocoa-derived flavanols and procyanidins have been previously reported to exhibit anti-oxidant and anti-tumor properties. In this study, we have investigated the cellular growth inhibitory effect of chemically-synthesized procyanidin 3-O-Galloylepicatechin-4b,8-3-O-galloylcatechin (GECGC) on a varie...