A Pilot Study Assessing the Impact of rs174537 on Circulating Polyunsaturated Fatty Acids and the Inflammatory Response in Patients with Traumatic Brain Injury

• Published in: Journal of neurotrauma Vol. 37; no. 17; pp. 1880 - 1891
• Main Authors: Waits, Charlotte Mae K, Bower, Aaron, Simms, Kelli N, Feldman, Bradford C, Kim, Nathan, Sergeant, Susan, Chilton, Floyd H, VandeVord, Pamela J, Langefeld, Carl D, Rahbar, Elaheh
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.09.2020; Mary Ann Liebert, Inc., publishers
• Subjects: Acyltransferases - blood; Adult; Biomarkers; Biomarkers - blood; Blood pressure; Brain Injuries, Traumatic - blood; Brain Injuries, Traumatic - diagnosis; Brain Injuries, Traumatic - genetics; Clinical outcomes; Deoxyribonucleic acid; DNA; Docosahexaenoic acid; Fatalities; Fatty acids; Fatty Acids, Omega-3 - blood; Fatty Acids, Omega-3 - genetics; Fatty Acids, Unsaturated - blood; Fatty Acids, Unsaturated - genetics; Female; Genetic diversity; Genotype & phenotype; Genotypes; Humans; Inflammation; Inflammation Mediators - blood; Interleukin 8; Male; Metabolic pathways; Metabolism; Middle Aged; Neuroprotection; Original; Patients; Pilot Projects; Plasma; Plasma levels; Polyunsaturated fatty acids; Prospective Studies; Single-nucleotide polymorphism; Trauma; Traumatic brain injury; Tumor necrosis factor-TNF; TBI; omega-3 fatty acids; rs174537; inflammatory cytokines; FADS variation

Traumatic brain injury (TBI) is a leading cause of death and disability in persons under age 45. The hallmark secondary injury profile after TBI involves dynamic interactions between inflammatory and metabolic pathways including fatty acids. Omega-3 polyunsaturated fatty acids (PUFAs) such as docosa...