Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA

• Published in: Human molecular genetics Vol. 21; no. 9; pp. 2102 - 2110
• Main Authors: Low, Siew-Kee, Takahashi, Atsushi, Cha, Pei-Chieng, Zembutsu, Hitoshi, Kamatani, Naoyuki, Kubo, Michiaki, Nakamura, Yusuke
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2012
• Subjects: Aneurysm; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Case-Control Studies; chromosome 4; chromosome 9; Chromosomes, Human, Pair 4 - genetics; Chromosomes, Human, Pair 9 - genetics; Cyclin-Dependent Kinase Inhibitor p15 - genetics; Fundamental and applied biological sciences. Psychology; Genetic factors; Genetic Predisposition to Disease; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Hemodynamics; Humans; Intracranial Aneurysm - genetics; Japan; Medical sciences; Molecular and cellular biology; Neurology; Polymorphism, Single Nucleotide; Receptor, Endothelin A - genetics; Single-nucleotide polymorphism; Stress; Stroke; subarachnoid hemorrhage; Transcription; Vascular diseases and vascular malformations of the nervous system; Asia; Japan; Human; Nervous system diseases; Genetic variant; Cardiovascular disease; Identification; Japanese; Cerebral disorder; Vascular disease; Association; intracranial aneurysm; Central nervous system disease; Genetics; Locus; Cerebrovascular disease

Aneurysmal subarachnoid hemorrhage (aSAH) is the most serious subtype of stroke. Genetic factors have been known to play an important role in the development of intracranial aneurysm (IA), some of which further progress to subarachnoid hemorrhage (SAH). In this study, we conducted a genome-wide asso...