Evidence of a Genetic Basis for the Different Geographic Occurrences of Liver/Kidney Microsomal Antibody Type 1 in Hepatitis C

• Published in: Digestive diseases and sciences Vol. 52; no. 1; pp. 179 - 184
• Main Authors: Muratori, Paolo, Czaja, Albert J., Muratori, Luigi, Granito, Alessandro, Guidi, Marcello, Ferri, Silvia, Volta, Umberto, Mantovani, Wilma, Pappas, Georgios, Cassani, Fabio, Lenzi, Marco, Bianchi, Francesco B.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.01.2007; Springer Nature B.V
• Subjects: Adult; Aged; Antibodies; Autoantibodies - genetics; Autoantibodies - immunology; Biological and medical sciences; European Continental Ancestry Group - genetics; Female; Haplotypes; Hepatitis C; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - immunology; Hepatitis, Autoimmune - genetics; HLA-DR Antigens - genetics; HLA-DR Antigens - immunology; HLA-DR7 Antigen - genetics; Human viral diseases; Humans; Infectious diseases; Interferon; Italy; Male; Medical sciences; Microsomes, Liver - immunology; Middle Aged; North America; Viral diseases; Viral hepatitis; Italy; North America; Human; Antibody; Leukocyte; Hepatic disease; Liver/kidney microsome antibodies; Microsome; Kidney; Infection; Antigen; Viral disease; Human leukocyte antigen; Digestive diseases; Genetics; Hepatitis C; Viral hepatitis C

Antibodies to liver/kidney microsome type 1 occur in Italian patients with hepatitis C, but rarely develop in North American patients. Our goals were to compare the frequencies of the HLA markers associated with autoimmune expression in Italian and North American patients with chronic hepatitis C an...