Regional Angiogenesis With Vascular Endothelial Growth Factor in Peripheral Arterial Disease A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Claudication

• Published in: Circulation (New York, N.Y.) Vol. 108; no. 16; pp. 1933 - 1938
• Main Authors: Rajagopalan, Sanjay, Mohler, Emile R., Lederman, Robert J., Mendelsohn, Farrell O., Saucedo, Jorge F., Goldman, Corey K., Blebea, John, Macko, Jennifer, Kessler, Paul D., Rasmussen, Henrik S., Annex, Brian H.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 21.10.2003; American Heart Association, Inc
• Subjects: Adenoviridae - genetics; Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Double-Blind Method; Edema - chemically induced; Endothelial Growth Factors - administration & dosage; Endothelial Growth Factors - adverse effects; Endothelial Growth Factors - genetics; Female; Genetic Therapy - adverse effects; Genetic Therapy - methods; Genetic Vectors - administration & dosage; Humans; Intercellular Signaling Peptides and Proteins - administration & dosage; Intercellular Signaling Peptides and Proteins - adverse effects; Intercellular Signaling Peptides and Proteins - genetics; Intermittent Claudication - etiology; Intermittent Claudication - therapy; Lymphokines - administration & dosage; Lymphokines - adverse effects; Lymphokines - genetics; Male; Medical sciences; Middle Aged; Neovascularization, Physiologic - drug effects; Peripheral Vascular Diseases - complications; Peripheral Vascular Diseases - therapy; Quality of Life; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Walking - statistics & numerical data; Human; Claudication; viruses; Prognosis; Cardiovascular disease; peripheral vascular disease; Genetic transfer; Arterial disease; Vascular disease; Angiogenesis; Vascular endothelium growth factor; Follow up study; Intermittent; Limb; Double blind study; Occlusive arterial disease; Gene therapy

Background— “Therapeutic angiogenesis” seeks to improve perfusion by the growth of new blood vessels. The Regional Angiogenesis with Vascular Endothelial growth factor (RAVE) trial is the first major randomized study of adenoviral vascular endothelial growth factor (VEGF) gene transfer for the treat...