Regional Angiogenesis With Vascular Endothelial Growth Factor in Peripheral Arterial Disease: A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Claudication - Rajagopalan, Sanjay; Mohler, Emile R.; Lederman, Robert J.; Mendelsohn, Farrell O.; Saucedo, Jorge F.; Goldman, Corey K.; Blebea, John; Macko, Jennifer; Kessler, Paul D.; Rasmussen, Henrik S.; Annex, Brian H. (Circulation (New York, N.Y.), 2003)
Keywords: Adenoviridae - genetics; Aged; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Double-Blind Method; Edema - chemically induced; Endothelial Growth Factors - administration & dosage; Endothelial Growth Factors - adverse effects; Endothelial Growth Factors - genetics; Female; Genetic Therapy - adverse effects; Genetic Therapy - methods; Genetic Vectors - administration & dosage; Humans; Intercellular Signaling Peptides and Proteins - administration & dosage; Intercellular Signaling Peptides and Proteins - adverse effects; Intercellular Signaling Peptides and Proteins - genetics; Intermittent Claudication - etiology; Intermittent Claudication - therapy; Lymphokines - administration & dosage; Lymphokines - adverse effects; Lymphokines - genetics; Male; Medical sciences; Middle Aged; Neovascularization, Physiologic - drug effects; Peripheral Vascular Diseases - complications; Peripheral Vascular Diseases - therapy; Quality of Life; Treatment Outcome; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Walking - statistics & numerical data; Human; Claudication; viruses; Prognosis; Cardiovascular disease; peripheral vascular disease; Genetic transfer; Arterial disease; Vascular disease; Angiogenesis; Vascular endothelium growth factor; Follow up study; Intermittent; Limb; Double blind study; Occlusive arterial disease; Gene therapy