Serum levels of soluble interleukin-2 receptor alpha (sIL-2Rα) as a predictor of outcome in brucellosis

Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment...

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Published inThe Journal of infection Vol. 51; no. 3; pp. 206 - 210
Main Authors Makis, Alexandros C., Galanakis, Emmanouil, Hatzimichael, Eleftheria C., Papadopoulou, Zoe L., Siamopoulou, Antigone, Bourantas, Konstantinos L.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.10.2005
Elsevier
Subjects
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Brucella
Brucellosis
Brucellosis - drug therapy
Brucellosis - microbiology
Child
Child, Preschool
Drug Therapy, Combination
Female
Human bacterial diseases
Humans
Infant
Infectious diseases
Interleukin-2 - blood
Interleukin-2 receptor
Interleukin-2 Receptor alpha Subunit
Male
Medical sciences
Miscellaneous
Predictive Value of Tests
Receptors, Interleukin-2 - blood
Rifampin - administration & dosage
Rifampin - therapeutic use
Solubility
Treatment Outcome
Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Brucellosis
Interleukin-2 receptor
Infection
Prognosis
Interleukin 2
Bacteriosis
Serum
Predictive factor
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Abstract Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2Rα) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended. Serum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2Rα levels were significantly higher in patients ( P≤0.0001) than in controls. sIL-2Rα levels significantly declined ( P<0.001) after the 6-week antibiotic regimen in the 17 children who subsequently had a good outcome without relapses, but not in the three patients who relapsed. A decline in serum sIL-2Rα levels might be used as a marker of treatment efficacy in brucellosis.
AbstractList Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2Rα) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended. Serum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2Rα levels were significantly higher in patients ( P≤0.0001) than in controls. sIL-2Rα levels significantly declined ( P<0.001) after the 6-week antibiotic regimen in the 17 children who subsequently had a good outcome without relapses, but not in the three patients who relapsed. A decline in serum sIL-2Rα levels might be used as a marker of treatment efficacy in brucellosis.
Objectives and methods Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2R) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended. Results Serum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2R levels were significantly higher in patients (P<=0.0001) than in controls. sIL-2R levels significantly declined (P<0.001) after the 6-week antibiotic regimen in the 17 children who subsequently had a good outcome without relapses, but not in the three patients who relapsed. Conclusions A decline in serum sIL-2R levels might be used as a marker of treatment efficacy in brucellosis.
OBJECTIVES AND METHODSBrucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2Ralpha) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended.RESULTSSerum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2Ralpha levels were significantly higher in patients (P< or =0.0001) than in controls. sIL-2Ralpha levels significantly declined (P<0.001) after the 6-week antibiotic regimen in the 17 children who subsequently had a good outcome without relapses, but not in the three patients who relapsed.CONCLUSIONSA decline in serum sIL-2Ralpha levels might be used as a marker of treatment efficacy in brucellosis.
Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2Ralpha) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended. Serum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2Ralpha levels were significantly higher in patients (P< or =0.0001) than in controls. sIL-2Ralpha levels significantly declined (P<0.001) after the 6-week antibiotic regimen in the 17 children who subsequently had a good outcome without relapses, but not in the three patients who relapsed. A decline in serum sIL-2Ralpha levels might be used as a marker of treatment efficacy in brucellosis.
Author Bourantas, Konstantinos L.
Hatzimichael, Eleftheria C.
Galanakis, Emmanouil
Papadopoulou, Zoe L.
Siamopoulou, Antigone
Makis, Alexandros C.
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Issue 3
Keywords Brucellosis
Interleukin-2 receptor
Infection
Prognosis
Interleukin 2
Bacteriosis
Serum
Predictive factor
Language English
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Snippet Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the...
Objectives and methods Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may...
OBJECTIVES AND METHODSBrucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may...
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SubjectTerms Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Brucella
Brucellosis
Brucellosis - drug therapy
Brucellosis - microbiology
Child
Child, Preschool
Drug Therapy, Combination
Female
Human bacterial diseases
Humans
Infant
Infectious diseases
Interleukin-2 - blood
Interleukin-2 receptor
Interleukin-2 Receptor alpha Subunit
Male
Medical sciences
Miscellaneous
Predictive Value of Tests
Receptors, Interleukin-2 - blood
Rifampin - administration & dosage
Rifampin - therapeutic use
Solubility
Treatment Outcome
Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Title Serum levels of soluble interleukin-2 receptor alpha (sIL-2Rα) as a predictor of outcome in brucellosis
URI https://dx.doi.org/10.1016/j.jinf.2004.10.013
https://www.ncbi.nlm.nih.gov/pubmed/16230217
https://search.proquest.com/docview/20823986
https://search.proquest.com/docview/68710213
Volume 51
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