Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study

• Published in: Brain (London, England : 1878) Vol. 128; no. 6; pp. 1454 - 1460
• Main Authors: Sastre-Garriga, Jaume, Ingle, Gordon T., Chard, Declan T., Cercignani, Mara, Ramió-Torrentà, Lluís, Miller, David H., Thompson, Alan J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2005; Oxford Publishing Limited (England)
• Subjects: 3DFSPGR = 3D inversion-prepared fast spoiled gradient recalled; Adult; Atrophy; Biological and medical sciences; Brain - pathology; Disease Progression; early phase; EDSS = Expanded Disability Status Scale; enhancing lesions; Female; FOV = field of view; GM = grey matter; grey matter atrophy; Humans; Image Processing, Computer-Assisted - methods; Immunomodulators; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; MSFC = Multiple Sclerosis Functional Composite; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Chronic Progressive - pathology; Neurology; NEX = number of excitations; of atrophy; Pharmacology. Drug treatments; PPMS = primary progressive multiple sclerosis; primary progressive multiple sclerosis; Severity of Illness Index; SIENA = structural image evaluation; SPM = statistical parametric mapping; ST = slice thickness; TE = echo time; TIV = total intracranial volume; TR = repetition time; using normalization; white matter atrophy; WM = white matter; Atrophy; Multiple sclerosis; Nervous system diseases; Early phase; Grey matter; primary progressive multiple sclerosis; Central nervous system disease; enhancing lesions; white matter atrophy; White matter; grey matter atrophy; Inflammatory disease

We have recently reported brain atrophy in the early stages of primary progressive multiple sclerosis (PPMS), affecting both grey and white matter (GM and WM). However, to date no clinical or radiological predictors of GM and WM atrophy have been identified. The aim was to investigate short-term cha...