Stratifin promotes the malignant progression of HCC via binding and hyperactivating AKT signaling

• Published in: Cancer letters Vol. 592; p. 216761
• Main Authors: Li, Rong, Yan, Xijing, Zhong, Wenhui, Zheng, Jun, Li, Xuejiao, Liang, Jinliang, Hu, Zhongying, Liu, Huanyi, Chen, Guihua, Yang, Yang, Zhang, Jianwei, Qu, Enze, Liu, Wei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.06.2024
• Subjects: 14-3-3 Proteins - genetics; 14-3-3 Proteins - metabolism; AKT; Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Proliferation; Disease Progression; Exoribonucleases - genetics; Exoribonucleases - metabolism; Female; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Humans; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Malignant progression; Mice; Middle Aged; Prognosis; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Stratifin; Therapeutic target; Hepatocellular carcinoma; AKT; Malignant progression; Stratifin; Therapeutic target

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with limited treatment options and poor prognosis. In this study, we reveal the pivotal role of Stratifin (SFN), also recognized as 14-3-3σ, in driving HCC progression. Our investigation underscores a substantial upregulation of S...