Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

• Published in: Nature medicine Vol. 24; no. 9; pp. 1418 - 1429
• Main Authors: Gomez, Delphine, Baylis, Richard A, Durgin, Brittany G, Newman, Alexandra A C, Alencar, Gabriel F, Mahan, Sidney, St Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E, Pinteaux, Emmanuel, Randolph, Gwendalyn J, Gram, Hermann, Owens, Gary K
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.09.2018
• Subjects: Animals; Antibodies; Antibodies, Neutralizing - pharmacology; Apolipoprotein E; Apoptosis - drug effects; Arteriosclerosis; Atherosclerosis; Atherosclerosis - metabolism; Atherosclerosis - pathology; Cell Polarity - drug effects; Cell Proliferation - drug effects; Collagen; Control stability; Down-Regulation - drug effects; Immunoglobulin G; Inflammation; Inflammation - pathology; Interleukin 1; Interleukin 1 receptors; Interleukin-1beta - metabolism; Lesions; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Monocytes - drug effects; Monocytes - metabolism; Muscles; Myocardial infarction; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Neutralization Tests; Phenotype; Signal Transduction - drug effects; Smooth muscle; Thromboembolism; Thrombosis

Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcom...