Neutrophil Count Is Associated With Reduced Gray Matter and Enlarged Ventricles in First-Episode Psychosis

Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain v...

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Published inSchizophrenia bulletin Vol. 45; no. 4; pp. 846 - 858
Main Authors Núñez, Christian, Stephan-Otto, Christian, Usall, Judith, Bioque, Miquel, Lobo, Antonio, González-Pinto, Ana, Pina-Camacho, Laura, Vieta, Eduard, Castro-Fornieles, Josefina, Rodriguez-Jimenez, Roberto, Butjosa, Anna, Janssen, Joost, Cabrera, Bibiana, Parellada, Mara, Bernardo, Miquel, Mezquida, Gisela, Amoretti, Silvia, Rodríguez-Toscano, Elisa, Alemán, Yasser, Zorrilla, Iñaki, García, Sainza, De-la-Cámara, Concepción, Barcones, Fe, Sanjuan, Julio, Jose Escartí, María, Mané, Anna, Cáceres, Iris, Tomioka, Yoko, Sánchez-Moreno, Jose, de la Serna, Elena, Baeza, Immaculada, Contreras, Fernando, Albacete, Àuria, Morales-Muñoz, Isabel, Dompablo, Mónica, Dolz, Montserrat, Rubio-Abadal, Elena, Pomarol-Clotet, Edith, Sarró, Salvador
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 18.06.2019
Subjects
Immune system
Neutrophils
Psychosis
Regular
Tissues
structural neuroimaging
neuroimmunology
hallucinations
avolition
leucocytes
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Abstract Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = -0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl's gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
AbstractList Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = −0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl’s gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = -0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl's gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = -0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl's gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = -0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl's gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T 1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (β = −0.117, P < .001) and increased cerebrospinal fluid volume (β = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl’s gyrus, among many others. Neutrophil count was also associated with the total PANSS score (β = 0.173, P = .038), including those items assessing hallucinations (β = 0.182, P = .028) and avolition (β = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
Author Pina-Camacho, Laura
Barcones, Fe
Jose Escartí, María
Bioque, Miquel
Mezquida, Gisela
Usall, Judith
Bernardo, Miquel
Rodríguez-Toscano, Elisa
Sanjuan, Julio
Núñez, Christian
Janssen, Joost
Lobo, Antonio
Vieta, Eduard
Morales-Muñoz, Isabel
Dompablo, Mónica
Butjosa, Anna
Alemán, Yasser
De-la-Cámara, Concepción
Contreras, Fernando
Baeza, Immaculada
Dolz, Montserrat
Pomarol-Clotet, Edith
Cáceres, Iris
Castro-Fornieles, Josefina
Mané, Anna
Zorrilla, Iñaki
García, Sainza
Parellada, Mara
Stephan-Otto, Christian
Rodriguez-Jimenez, Roberto
Sarró, Salvador
González-Pinto, Ana
Tomioka, Yoko
de la Serna, Elena
Cabrera, Bibiana
Sánchez-Moreno, Jose
Rubio-Abadal, Elena
Albacete, Àuria
Amoretti, Silvia
AuthorAffiliation 4 Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clínic de Barcelona, Barcelona, Spain
13 Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
14 Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
2 Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain
1 Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
12 Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
10 Child and Adolescent Psychiatry and Psychology Department, Clinic Institute of Neurosciences, Hospital Clínic de Barcelona, Barcelona, Spain
6 Department of Medicine and Psychiatry, Instituto de Investigación Sanitaria Aragón, Universidad de Zaragoza, Zaragoza, Spain
11 Department of Medicine, University of Barcelona, Barcelona, Spain
5 Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
7 International Mood Disorde
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30107610$$D View this record in MEDLINE/PubMed
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Keywords structural neuroimaging
neuroimmunology
hallucinations
avolition
leucocytes
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Snippet Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as...
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SubjectTerms Immune system
Neutrophils
Psychosis
Regular
Tissues
Title Neutrophil Count Is Associated With Reduced Gray Matter and Enlarged Ventricles in First-Episode Psychosis
URI https://www.ncbi.nlm.nih.gov/pubmed/30107610
https://www.proquest.com/docview/3192249881
https://www.proquest.com/docview/2088752270
https://pubmed.ncbi.nlm.nih.gov/PMC6581126
Volume 45
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