Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence

Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellu...

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Published inInternational journal of molecular sciences Vol. 22; no. 20; p. 11237
Main Authors Khoi, Chong-Sun, Chen, Jia-Huang, Lin, Tzu-Yu, Chiang, Chih-Kang, Hung, Kuan-Yu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.10.2021
MDPI
Subjects
Animals
Apoptosis
Biomarkers
Carcinogens - toxicity
Cell cycle
DNA damage
Food contamination & poisoning
Humans
Kidney diseases
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kinases
Nitric oxide
Ochratoxins - toxicity
Oxidative stress
Plasma
Proteins
Review
Urine
ochratoxin A
molecular interaction
nephrotoxicity
prevention
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Abstract Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
AbstractList Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
Author Hung, Kuan-Yu
Chen, Jia-Huang
Lin, Tzu-Yu
Chiang, Chih-Kang
Khoi, Chong-Sun
AuthorAffiliation 2 Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan
3 Department of Internal Medicine, College of Medicine and Hospital, National Taiwan University, Taipei 106, Taiwan; kyhung@ntu.edu.tw
1 Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, Taiwan; d05447005@ntu.edu.tw (C.-S.K.); f04447010@ntu.edu.tw (J.-H.C.)
4 Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei 10002, Taiwan
AuthorAffiliation_xml – name: 4 Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei 10002, Taiwan
– name: 1 Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 106, Taiwan; d05447005@ntu.edu.tw (C.-S.K.); f04447010@ntu.edu.tw (J.-H.C.)
– name: 2 Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan
– name: 3 Department of Internal Medicine, College of Medicine and Hospital, National Taiwan University, Taipei 106, Taiwan; kyhung@ntu.edu.tw
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Cites_doi 10.1016/j.cbi.2005.10.106
10.2147/DMSO.S287287
10.1080/10408398.2012.724480
10.1021/acs.jafc.7b02115
10.1007/s00204-017-2107-6
10.1016/j.tox.2020.152582
10.1007/BF02954817
10.1515/hsz-2020-0167
10.1016/j.ab.2017.07.009
10.1007/s12550-016-0261-y
10.1016/j.fct.2018.11.015
10.1016/j.taap.2013.01.021
10.1016/j.toxlet.2017.04.013
10.1007/s00204-021-02993-6
10.1016/j.tox.2017.03.009
10.1007/s12011-018-1532-6
10.1016/j.fct.2020.111436
10.1023/A:1007662101880
10.1016/j.tox.2004.08.004
10.1016/j.fct.2020.111516
10.1007/s004240000321
10.3109/1354750X.2012.692392
10.1016/j.toxicon.2017.07.013
10.1002/tox.22443
10.3389/fvets.2020.00136
10.1002/mnfr.200600137
10.1021/jf011015z
10.1006/taap.2000.8987
10.1016/j.tox.2006.06.004
10.1038/srep08078
10.1081/JDI-200026744
10.1021/tx200430f
10.1016/j.jphotobiol.2014.01.016
10.1002/jcb.25425
10.1016/j.fct.2019.110720
10.1093/toxsci/kfp090
10.1021/tx049650x
10.1016/j.taap.2015.09.023
10.18632/oncotarget.14270
10.1016/j.redox.2013.09.003
10.1016/j.tox.2021.152681
10.1292/jvms.16-0226
10.1080/15376516.2017.1411412
10.1016/j.rvsc.2021.07.007
10.1016/j.tox.2017.07.004
10.1016/j.toxicon.2020.05.014
10.3390/toxins11110638
10.3390/antiox9040332
10.1016/j.biocel.2017.01.003
10.3390/cells9010143
10.1080/15592294.2019.1644878
10.1515/aiht-2017-68-2905
10.1515/jvetres-2017-0071
10.1007/s12550-015-0223-9
10.1016/j.fct.2018.08.026
10.1080/02652030210151895
10.1016/j.fct.2014.04.039
10.1016/j.toxicon.2020.04.097
10.1111/jpn.12682
10.1016/j.biopha.2019.109629
10.1016/j.fct.2016.12.002
10.1111/j.1439-0396.2008.00838.x
10.1016/j.toxicon.2020.03.012
10.1016/j.tox.2014.07.012
10.1016/j.etap.2015.12.005
10.1016/j.fct.2019.110883
10.1016/j.toxrep.2019.11.015
10.1080/02652039609374384
10.1016/j.tiv.2019.03.016
10.1016/j.tox.2012.12.005
10.1016/j.fct.2018.09.070
10.1002/jcp.29425
10.1016/j.lfs.2019.116735
10.1002/mnfr.201200456
10.1007/s00204-019-02434-5
10.1002/jcb.26197
10.3920/WMJ2014.1795
10.1016/j.reprotox.2006.04.022
10.1016/j.toxicon.2021.08.002
10.3390/antiox10081239
10.1016/S0168-1605(02)00310-0
10.1016/S1532-0456(01)00248-4
10.1021/tx900295a
10.1016/j.bbrc.2011.06.190
10.3390/toxins13030190
10.5414/CNP83S064
10.1021/tx049877s
10.1016/j.chemosphere.2017.05.030
10.1007/s12192-017-0790-0
10.1016/j.fct.2018.10.004
10.1002/mnfr.200500124
10.1016/j.toxicon.2019.07.014
10.1007/s11906-009-0011-z
10.1016/j.toxicon.2021.06.005
10.1096/fj.201800742R
10.1002/tox.23308
10.1007/s00204-014-1311-x
10.1016/j.tox.2019.152324
10.1016/S0925-4439(02)00159-X
10.3390/molecules25061386
10.3390/toxins11110615
10.1016/j.ijbiomac.2019.11.221
10.1016/j.ecoenv.2019.109637
10.1016/j.cbi.2017.10.020
10.1016/j.fct.2016.12.037
10.1080/02652030500309368
10.1016/0278-6915(84)90170-4
10.1007/s00204-020-02829-9
10.1007/s00204-003-0501-8
10.1002/jcp.26753
10.1016/j.mrfmmm.2014.05.001
10.1177/096032719801700207
10.1016/0041-008X(91)90332-9
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Keywords ochratoxin A
molecular interaction
nephrotoxicity
prevention
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References Fadl (ref_111) 2020; 184
Munoz (ref_19) 2017; 33
Darbuka (ref_43) 2021; 199
Damiano (ref_97) 2020; 235
Taniwaki (ref_4) 2003; 82
Yang (ref_63) 2014; 765
Raghubeer (ref_82) 2017; 137
ref_95
Aleo (ref_71) 1991; 107
Ostry (ref_16) 2005; 21
Meucci (ref_14) 2017; 79
Li (ref_102) 2020; 2020
Malir (ref_17) 2012; 17
Gekle (ref_37) 2000; 293
Zhang (ref_115) 2020; 13
Gerding (ref_20) 2015; 31
Mitchell (ref_23) 2017; 100
Zhou (ref_56) 2017; 278
Gan (ref_106) 2021; 139
Yaman (ref_27) 2015; 89
Gong (ref_26) 2019; 123
ref_24
Gagliano (ref_6) 2006; 225
Meki (ref_28) 2001; 130
Zheng (ref_109) 2013; 268
Creppy (ref_59) 1984; 22
Silva (ref_22) 2020; 135
Liu (ref_92) 2020; 181
Li (ref_55) 2015; 8
Bodiga (ref_110) 2020; 401
Damiano (ref_93) 2018; 233
Sheu (ref_8) 2017; 8
Qi (ref_45) 2018; 121
Agarwal (ref_61) 2020; 429
Kamp (ref_47) 2005; 49
ref_77
Gan (ref_103) 2020; 146
Kosicki (ref_15) 2021; 200
Wagner (ref_104) 2009; 93
Petrik (ref_38) 2003; 77
Palabiyik (ref_107) 2017; 68
Faucet (ref_51) 2004; 17
Gurbuz (ref_65) 2020; 180
Li (ref_90) 2019; 168
Sage (ref_2) 2002; 50
Nogaim (ref_96) 2020; 7
Liu (ref_114) 2020; 141
Limbeck (ref_57) 2018; 92
Gan (ref_83) 2017; 32
Fusi (ref_81) 2018; 102
Schwerdt (ref_36) 1999; 15
Raghubeer (ref_87) 2019; 57
Gan (ref_44) 2017; 182
Li (ref_46) 2021; 95
Zhang (ref_58) 2020; 15
Chebotareva (ref_72) 2017; 22
Qian (ref_78) 2018; 122
Crupi (ref_33) 2020; 7
Wu (ref_11) 2015; 55
Mally (ref_48) 2005; 18
Yang (ref_67) 2019; 33
Manderville (ref_50) 2012; 25
Hsieh (ref_13) 2004; 26
Fernandes (ref_91) 2018; 28
Wafa (ref_12) 1998; 17
Fuchs (ref_5) 2005; 22
Zrinski (ref_60) 2000; 167
Jarmi (ref_85) 2009; 11
Cavin (ref_32) 2009; 110
Ren (ref_101) 2019; 190
Eder (ref_69) 2000; 440
Jorgensen (ref_3) 1996; 13
Yang (ref_84) 2017; 382
Veres (ref_70) 2014; 132
Aljawish (ref_113) 2017; 99
Le (ref_80) 2020; 143
Yang (ref_64) 2014; 70
Yang (ref_73) 2019; 133
Liang (ref_30) 2015; 5
Damiano (ref_35) 2018; 119
ref_66
Stefanovic (ref_10) 2015; 83
Schaaf (ref_29) 2002; 1588
Li (ref_108) 2019; 234
Zorova (ref_68) 2018; 552
Pyo (ref_79) 2020; 94
Imaoka (ref_89) 2020; 444
Ciarcia (ref_98) 2016; 117
Stachurska (ref_76) 2013; 57
Loboda (ref_88) 2017; 389
Loboda (ref_86) 2017; 84
Gan (ref_105) 2017; 65
Patil (ref_7) 2006; 22
Zhang (ref_42) 2021; 450
Lee (ref_31) 2018; 122
ref_34
Gan (ref_53) 2019; 93
Ozden (ref_54) 2015; 289
Hibi (ref_49) 2013; 304
Li (ref_39) 2011; 411
Hennemeier (ref_75) 2014; 324
Jiang (ref_99) 2020; 121
Kamp (ref_62) 2005; 206
Mantle (ref_52) 2010; 23
Ali (ref_21) 2017; 275
Marin (ref_74) 2019; 184
Dalcero (ref_1) 2002; 19
Manderville (ref_9) 2007; 51
ref_100
ref_41
ref_40
Aljawish (ref_112) 2016; 41
Trujillo (ref_94) 2013; 1
Ringot (ref_18) 2006; 159
Pietruszka (ref_25) 2017; 61
References_xml – volume: 159
  start-page: 18
  year: 2006
  ident: ref_18
  article-title: Toxicokinetics and toxicodynamics of ochratoxin A, an update
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2005.10.106
– volume: 13
  start-page: 4801
  year: 2020
  ident: ref_115
  article-title: Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway
  publication-title: Diabetes Metab. Syndr. Obes.
  doi: 10.2147/DMSO.S287287
– volume: 55
  start-page: 1860
  year: 2015
  ident: ref_11
  article-title: Ochratoxin A and human health risk: A review of the evidence
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2012.724480
– volume: 65
  start-page: 6972
  year: 2017
  ident: ref_105
  article-title: Overexpression and Low Expression of Selenoprotein S Impact Ochratoxin A-Induced Porcine Cytotoxicity and Apoptosis in Vitro
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.7b02115
– volume: 92
  start-page: 995
  year: 2018
  ident: ref_57
  article-title: Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-017-2107-6
– volume: 444
  start-page: 152582
  year: 2020
  ident: ref_89
  article-title: Microphysiological system modeling of ochratoxin A-associated nephrotoxicity
  publication-title: Toxicology
  doi: 10.1016/j.tox.2020.152582
– volume: 21
  start-page: 49
  year: 2005
  ident: ref_16
  article-title: Monitoring of mycotoxin biomarkers in the Czech Republic
  publication-title: Mycotoxin Res.
  doi: 10.1007/BF02954817
– volume: 401
  start-page: 1257
  year: 2020
  ident: ref_110
  article-title: Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation
  publication-title: Biol. Chem.
  doi: 10.1515/hsz-2020-0167
– volume: 552
  start-page: 50
  year: 2018
  ident: ref_68
  article-title: Mitochondrial membrane potential
  publication-title: Anal. Biochem.
  doi: 10.1016/j.ab.2017.07.009
– volume: 33
  start-page: 39
  year: 2017
  ident: ref_19
  article-title: Evidence of ochratoxin A conjugates in urine samples from infants and adults
  publication-title: Mycotoxin Res.
  doi: 10.1007/s12550-016-0261-y
– volume: 123
  start-page: 374
  year: 2019
  ident: ref_26
  article-title: Molecular signatures of cytotoxic effects in human embryonic kidney 293cells treated with single and mixture of ochratoxin A and citrinin
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2018.11.015
– volume: 268
  start-page: 123
  year: 2013
  ident: ref_109
  article-title: Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2013.01.021
– volume: 275
  start-page: 19
  year: 2017
  ident: ref_21
  article-title: Ochratoxin A and its metabolites in urines of German adults—An assessment of variables in biomarker analysis
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2017.04.013
– volume: 95
  start-page: 1489
  year: 2021
  ident: ref_46
  article-title: Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-021-02993-6
– volume: 382
  start-page: 75
  year: 2017
  ident: ref_84
  article-title: Ochratoxin A induced premature senescence in human renal proximal tubular cells
  publication-title: Toxicology
  doi: 10.1016/j.tox.2017.03.009
– volume: 190
  start-page: 273
  year: 2019
  ident: ref_101
  article-title: Research Progress on the Toxic Antagonism of Selenium Against Mycotoxins
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-018-1532-6
– volume: 293
  start-page: 837
  year: 2000
  ident: ref_37
  article-title: Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 141
  start-page: 111436
  year: 2020
  ident: ref_114
  article-title: Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2020.111436
– volume: 15
  start-page: 405
  year: 1999
  ident: ref_36
  article-title: The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells
  publication-title: Cell Biol. Toxicol.
  doi: 10.1023/A:1007662101880
– volume: 206
  start-page: 413
  year: 2005
  ident: ref_62
  article-title: Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells
  publication-title: Toxicology
  doi: 10.1016/j.tox.2004.08.004
– volume: 143
  start-page: 111516
  year: 2020
  ident: ref_80
  article-title: Ochratoxin A induces glomerular injury through activating the ERK/NF-κB signaling pathway
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2020.111516
– volume: 440
  start-page: 521
  year: 2000
  ident: ref_69
  article-title: Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells
  publication-title: Pflugers Arch.
  doi: 10.1007/s004240000321
– volume: 17
  start-page: 577
  year: 2012
  ident: ref_17
  article-title: Ochratoxin A exposure biomarkers in the Czech Republic and comparison with foreign countries
  publication-title: Biomarkers
  doi: 10.3109/1354750X.2012.692392
– volume: 137
  start-page: 48
  year: 2017
  ident: ref_82
  article-title: Acute Ochratoxin A exposure induces inflammation and apoptosis in human embryonic kidney (HEK293) cells
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2017.07.013
– volume: 32
  start-page: 2277
  year: 2017
  ident: ref_83
  article-title: Effects of ochratoxin A on ER stress, MAPK signaling pathway and autophagy of kidney and spleen in pigs
  publication-title: Environ. Toxicol.
  doi: 10.1002/tox.22443
– volume: 7
  start-page: 136
  year: 2020
  ident: ref_33
  article-title: Protective Effect of Hydroxytyrosol Against Oxidative Stress Induced by the Ochratoxin in Kidney Cells: In vitro and in vivo Study
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2020.00136
– volume: 51
  start-page: 61
  year: 2007
  ident: ref_9
  article-title: Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.200600137
– volume: 50
  start-page: 1306
  year: 2002
  ident: ref_2
  article-title: Fungal flora and ochratoxin a production in grapes and musts from france
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf011015z
– volume: 167
  start-page: 132
  year: 2000
  ident: ref_60
  article-title: Studies of ochratoxin A-induced inhibition of phenylalanine hydroxylase and its reversal by phenylalanine
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1006/taap.2000.8987
– volume: 225
  start-page: 214
  year: 2006
  ident: ref_6
  article-title: Early cytotoxic effects of ochratoxin A in rat liver: A morphological, biochemical and molecular study
  publication-title: Toxicology
  doi: 10.1016/j.tox.2006.06.004
– volume: 5
  start-page: 8078
  year: 2015
  ident: ref_30
  article-title: Apoptosis signal-regulating kinase 1 promotes Ochratoxin A-induced renal cytotoxicity
  publication-title: Sci. Rep.
  doi: 10.1038/srep08078
– volume: 26
  start-page: 311
  year: 2004
  ident: ref_13
  article-title: Does human ochratoxin A aggravate proteinuria in patients with chronic renal disease?
  publication-title: Ren Fail.
  doi: 10.1081/JDI-200026744
– volume: 25
  start-page: 252
  year: 2012
  ident: ref_50
  article-title: An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx200430f
– volume: 132
  start-page: 1
  year: 2014
  ident: ref_70
  article-title: Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A
  publication-title: J. Photochem. Photobiol. B
  doi: 10.1016/j.jphotobiol.2014.01.016
– volume: 117
  start-page: 1352
  year: 2016
  ident: ref_98
  article-title: Recombinant Mitochondrial Manganese Containing Superoxide Dismutase Protects Against Ochratoxin A-Induced Nephrotoxicity
  publication-title: J. Cell Biochem.
  doi: 10.1002/jcb.25425
– volume: 133
  start-page: 110720
  year: 2019
  ident: ref_73
  article-title: Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2019.110720
– volume: 110
  start-page: 84
  year: 2009
  ident: ref_32
  article-title: Ochratoxin A-mediated DNA and protein damage: Roles of nitrosative and oxidative stresses
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kfp090
– volume: 18
  start-page: 1253
  year: 2005
  ident: ref_48
  article-title: Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx049650x
– volume: 289
  start-page: 203
  year: 2015
  ident: ref_54
  article-title: Assessment of global and gene-specific DNA methylation in rat liver and kidney in response to non-genotoxic carcinogen exposure
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2015.09.023
– volume: 8
  start-page: 19376
  year: 2017
  ident: ref_8
  article-title: Ochratoxin A induces ER stress and apoptosis in mesangial cells via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14270
– volume: 1
  start-page: 448
  year: 2013
  ident: ref_94
  article-title: Renoprotective effect of the antioxidant curcumin: Recent findings
  publication-title: Redox. Biol.
  doi: 10.1016/j.redox.2013.09.003
– volume: 450
  start-page: 152681
  year: 2021
  ident: ref_42
  article-title: Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A
  publication-title: Toxicology
  doi: 10.1016/j.tox.2021.152681
– volume: 79
  start-page: 440
  year: 2017
  ident: ref_14
  article-title: Serum levels of ochratoxin A in dogs with chronic kidney disease (CKD): A retrospective study
  publication-title: J. Vet. Med. Sci.
  doi: 10.1292/jvms.16-0226
– volume: 28
  start-page: 328
  year: 2018
  ident: ref_91
  article-title: N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats
  publication-title: Toxicol. Mech. Methods
  doi: 10.1080/15376516.2017.1411412
– volume: 139
  start-page: 94
  year: 2021
  ident: ref_106
  article-title: Effects of Selenium-enriched probiotics on ochratoxin A-induced kidney injury and DNMTs expressions in piglets
  publication-title: Res. Vet. Sci.
  doi: 10.1016/j.rvsc.2021.07.007
– volume: 389
  start-page: 42
  year: 2017
  ident: ref_88
  article-title: Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo
  publication-title: Toxicology
  doi: 10.1016/j.tox.2017.07.004
– volume: 184
  start-page: 1
  year: 2020
  ident: ref_111
  article-title: Trial for reduction of Ochratoxin A residues in fish feed by using nano particles of hydrated sodium aluminum silicates (NPsHSCAS) and copper oxide
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2020.05.014
– ident: ref_24
  doi: 10.3390/toxins11110638
– ident: ref_95
  doi: 10.3390/antiox9040332
– volume: 84
  start-page: 46
  year: 2017
  ident: ref_86
  article-title: Effect of heme oxygenase-1 on ochratoxin A-induced nephrotoxicity in mice
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2017.01.003
– ident: ref_66
  doi: 10.3390/cells9010143
– volume: 15
  start-page: 199
  year: 2020
  ident: ref_58
  article-title: An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest
  publication-title: Epigenetics
  doi: 10.1080/15592294.2019.1644878
– volume: 68
  start-page: 135
  year: 2017
  ident: ref_107
  article-title: Lycopene restores trace element levels in ochratoxin A-treated rats
  publication-title: Arh. Hig. Rada Toksikol.
  doi: 10.1515/aiht-2017-68-2905
– volume: 61
  start-page: 483
  year: 2017
  ident: ref_25
  article-title: Occurrence of Ochratoxin a in Animal Tissues and Feeds in Poland in 2014–2016
  publication-title: J. Vet. Res.
  doi: 10.1515/jvetres-2017-0071
– volume: 31
  start-page: 127
  year: 2015
  ident: ref_20
  article-title: A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach
  publication-title: Mycotoxin Res.
  doi: 10.1007/s12550-015-0223-9
– volume: 121
  start-page: 15
  year: 2018
  ident: ref_45
  article-title: Mitigation of cell apoptosis induced by ochratoxin A (OTA) is possibly through organic cation transport 2 (OCT2) knockout
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2018.08.026
– volume: 19
  start-page: 1065
  year: 2002
  ident: ref_1
  article-title: Detection of ochratoxin A in animal feeds and capacity to produce this mycotoxin by Aspergillus section Nigri in Argentina
  publication-title: Food Addit. Contam.
  doi: 10.1080/02652030210151895
– volume: 70
  start-page: 40
  year: 2014
  ident: ref_64
  article-title: Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by ochratoxin A in human embryonic kidney cells (HEK-293)
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2014.04.039
– volume: 181
  start-page: 82
  year: 2020
  ident: ref_92
  article-title: Regulation of taurine in OTA-induced apoptosis and autophagy
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2020.04.097
– volume: 102
  start-page: 350
  year: 2018
  ident: ref_81
  article-title: Ochratoxin A cytotoxicity on Madin-Darby canine kidney cells in the presence of alpha-tocopherol: Effects on cell viability and tight junctions
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/jpn.12682
– volume: 121
  start-page: 109629
  year: 2020
  ident: ref_99
  article-title: Maintenance of mitochondrial function by astaxanthin protects against bisphenol A-induced kidney toxicity in rats
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2019.109629
– volume: 99
  start-page: 209
  year: 2017
  ident: ref_113
  article-title: Chitosan nanoparticles plus quercetin suppress the oxidative stress, modulate DNA fragmentation and gene expression in the kidney of rats fed ochratoxin A-contaminated diet
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2016.12.002
– volume: 93
  start-page: 547
  year: 2009
  ident: ref_104
  article-title: Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells
  publication-title: J. Anim. Physiol. Anim. Nutr.
  doi: 10.1111/j.1439-0396.2008.00838.x
– volume: 180
  start-page: 11
  year: 2020
  ident: ref_65
  article-title: Ochratoxin A causes cell cycle arrest in G1 and G1/S phases through p53 in HK-2 cells
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2020.03.012
– volume: 324
  start-page: 116
  year: 2014
  ident: ref_75
  article-title: Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells
  publication-title: Toxicology
  doi: 10.1016/j.tox.2014.07.012
– volume: 2020
  start-page: 4048706
  year: 2020
  ident: ref_102
  article-title: Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens
  publication-title: Oxid. Med. Cell Longev.
– volume: 41
  start-page: 279
  year: 2016
  ident: ref_112
  article-title: Grafting of gallic acid onto chitosan nano particles enhances antioxidant activities in vitro and protects against ochratoxin A toxicity in catfish (Clarias gariepinus)
  publication-title: Environ. Toxicol. Pharmacol.
  doi: 10.1016/j.etap.2015.12.005
– volume: 135
  start-page: 110883
  year: 2020
  ident: ref_22
  article-title: Ochratoxin A and Portuguese children: Urine biomonitoring, intake estimation and risk assessment
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2019.110883
– volume: 7
  start-page: 142
  year: 2020
  ident: ref_96
  article-title: Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A
  publication-title: Toxicol. Rep.
  doi: 10.1016/j.toxrep.2019.11.015
– volume: 13
  start-page: 95
  year: 1996
  ident: ref_3
  article-title: Ochratoxin A in Danish cereals 1986–1992 and daily intake by the Danish population
  publication-title: Food Addit. Contam.
  doi: 10.1080/02652039609374384
– volume: 57
  start-page: 211
  year: 2019
  ident: ref_87
  article-title: Ochratoxin A upregulates biomarkers associated with hypoxia and transformation in human kidney cells
  publication-title: Toxicol. In Vitro
  doi: 10.1016/j.tiv.2019.03.016
– volume: 304
  start-page: 92
  year: 2013
  ident: ref_49
  article-title: Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice
  publication-title: Toxicology
  doi: 10.1016/j.tox.2012.12.005
– volume: 122
  start-page: 120
  year: 2018
  ident: ref_78
  article-title: Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2018.09.070
– volume: 235
  start-page: 5386
  year: 2020
  ident: ref_97
  article-title: Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.29425
– volume: 234
  start-page: 116735
  year: 2019
  ident: ref_108
  article-title: Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2019.116735
– volume: 57
  start-page: 504
  year: 2013
  ident: ref_76
  article-title: Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201200456
– volume: 93
  start-page: 1067
  year: 2019
  ident: ref_53
  article-title: Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-019-02434-5
– volume: 119
  start-page: 424
  year: 2018
  ident: ref_35
  article-title: Effect of rMnSOD on Sodium Reabsorption in Renal Proximal Tubule in Ochratoxin A-Treated Rats
  publication-title: J. Cell Biochem.
  doi: 10.1002/jcb.26197
– volume: 8
  start-page: 465
  year: 2015
  ident: ref_55
  article-title: Dynamic changes of global DNA methylation and hypermethylation of cell adhesion-related genes in rat kidneys in response to Ochratoxin A
  publication-title: World Mycotoxin J.
  doi: 10.3920/WMJ2014.1795
– volume: 22
  start-page: 679
  year: 2006
  ident: ref_7
  article-title: Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats
  publication-title: Reprod. Toxicol.
  doi: 10.1016/j.reprotox.2006.04.022
– volume: 200
  start-page: 183
  year: 2021
  ident: ref_15
  article-title: Ochratoxin A levels in serum of Polish dialysis patients with chronic renal failure
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2021.08.002
– ident: ref_34
  doi: 10.3390/antiox10081239
– volume: 82
  start-page: 173
  year: 2003
  ident: ref_4
  article-title: The source of ochratoxin A in Brazilian coffee and its formation in relation to processing methods
  publication-title: Int. J. Food Microbiol.
  doi: 10.1016/S0168-1605(02)00310-0
– volume: 130
  start-page: 305
  year: 2001
  ident: ref_28
  article-title: Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney
  publication-title: Comp. Biochem. Physiol. C Toxicol. Pharmacol.
  doi: 10.1016/S1532-0456(01)00248-4
– volume: 23
  start-page: 89
  year: 2010
  ident: ref_52
  article-title: Structures of covalent adducts between DNA and ochratoxin a: A new factor in debate about genotoxicity and human risk assessment
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx900295a
– volume: 411
  start-page: 458
  year: 2011
  ident: ref_39
  article-title: p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.06.190
– ident: ref_41
  doi: 10.3390/toxins13030190
– volume: 83
  start-page: 64
  year: 2015
  ident: ref_10
  article-title: Balkan nephropathy
  publication-title: Clin. Nephrol.
  doi: 10.5414/CNP83S064
– volume: 17
  start-page: 1289
  year: 2004
  ident: ref_51
  article-title: Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx049877s
– volume: 182
  start-page: 630
  year: 2017
  ident: ref_44
  article-title: Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15 cells and porcine primary splenocytes
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2017.05.030
– volume: 22
  start-page: 319
  year: 2017
  ident: ref_72
  article-title: Heat shock proteins and kidney disease: Perspectives of HSP therapy
  publication-title: Cell Stress Chaperones
  doi: 10.1007/s12192-017-0790-0
– volume: 122
  start-page: 59
  year: 2018
  ident: ref_31
  article-title: Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2018.10.004
– volume: 49
  start-page: 1160
  year: 2005
  ident: ref_47
  article-title: Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.200500124
– volume: 168
  start-page: 141
  year: 2019
  ident: ref_90
  article-title: Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2019.07.014
– volume: 11
  start-page: 56
  year: 2009
  ident: ref_85
  article-title: Heme oxygenase and renal disease
  publication-title: Curr. Hypertens. Rep.
  doi: 10.1007/s11906-009-0011-z
– volume: 199
  start-page: 79
  year: 2021
  ident: ref_43
  article-title: Ochratoxin A induces ERK1/2 phosphorylation-dependent apoptosis through NF-κB/ERK axis in human proximal tubule HK-2 cell line
  publication-title: Toxicon
  doi: 10.1016/j.toxicon.2021.06.005
– volume: 33
  start-page: 2212
  year: 2019
  ident: ref_67
  article-title: Precision toxicology shows that troxerutin alleviates ochratoxin A-induced renal lipotoxicity
  publication-title: FASEB J.
  doi: 10.1096/fj.201800742R
– ident: ref_40
  doi: 10.1002/tox.23308
– volume: 89
  start-page: 1313
  year: 2015
  ident: ref_27
  article-title: Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-014-1311-x
– volume: 429
  start-page: 152324
  year: 2020
  ident: ref_61
  article-title: Amelioration of ochratoxin-A induced cytotoxicity by prophylactic treatment of N-Acetyl-L-Tryptophan in human embryonic kidney cells
  publication-title: Toxicology
  doi: 10.1016/j.tox.2019.152324
– volume: 1588
  start-page: 149
  year: 2002
  ident: ref_29
  article-title: The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0925-4439(02)00159-X
– ident: ref_100
  doi: 10.3390/molecules25061386
– ident: ref_77
  doi: 10.3390/toxins11110615
– volume: 146
  start-page: 18
  year: 2020
  ident: ref_103
  article-title: GPx1-mediated DNMT1 expression is involved in the blocking effects of selenium on OTA-induced cytotoxicity and DNA damage
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2019.11.221
– volume: 184
  start-page: 109637
  year: 2019
  ident: ref_74
  article-title: MicroRNA profiling in kidney in pigs fed ochratoxin A contaminated diet
  publication-title: Ecotoxicol. Environ. Saf
  doi: 10.1016/j.ecoenv.2019.109637
– volume: 278
  start-page: 170
  year: 2017
  ident: ref_56
  article-title: Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2017.10.020
– volume: 100
  start-page: 265
  year: 2017
  ident: ref_23
  article-title: A risk assessment of dietary Ochratoxin a in the United States
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2016.12.037
– volume: 22
  start-page: 53
  year: 2005
  ident: ref_5
  article-title: Ochratoxin A in human kidney diseases
  publication-title: Food Addit. Contam.
  doi: 10.1080/02652030500309368
– volume: 22
  start-page: 883
  year: 1984
  ident: ref_59
  article-title: Inhibition of protein synthesis in mice by ochratoxin A and its prevention by phenylalanine
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/0278-6915(84)90170-4
– volume: 94
  start-page: 3329
  year: 2020
  ident: ref_79
  article-title: Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-β/Smad2/3 and Wnt1/β-catenin signaling pathways in vitro and in vivo
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-020-02829-9
– volume: 77
  start-page: 685
  year: 2003
  ident: ref_38
  article-title: Apoptosis and oxidative stress induced by ochratoxin A in rat kidney
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-003-0501-8
– volume: 233
  start-page: 8731
  year: 2018
  ident: ref_93
  article-title: Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.26753
– volume: 765
  start-page: 22
  year: 2014
  ident: ref_63
  article-title: DNA damage and S phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK 293)
  publication-title: Mutat Res.
  doi: 10.1016/j.mrfmmm.2014.05.001
– volume: 17
  start-page: 124
  year: 1998
  ident: ref_12
  article-title: Human ochratoxicosis and nephropathy in Egypt: A preliminary study
  publication-title: Hum. Exp. Toxicol.
  doi: 10.1177/096032719801700207
– volume: 107
  start-page: 73
  year: 1991
  ident: ref_71
  article-title: Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/0041-008X(91)90332-9
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Snippet Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA...
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StartPage 11237
SubjectTerms Animals
Apoptosis
Biomarkers
Carcinogens - toxicity
Cell cycle
DNA damage
Food contamination & poisoning
Humans
Kidney diseases
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kinases
Nitric oxide
Ochratoxins - toxicity
Oxidative stress
Plasma
Proteins
Review
Urine
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Title Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence
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