IL‑6/STAT3 signaling pathway regulates the proliferation and damage of intestinal epithelial cells in patients with ulcerative colitis via H3K27ac

• Published in: Experimental and therapeutic medicine Vol. 22; no. 2; p. 890
• Main Authors: Li, Yanrong, Jia, Yujie, Cui, Tingfang, Zhang, Jiayuan
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.08.2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antibodies; Biotechnology; Cell culture; Cell proliferation; Cellular signal transduction; Colon; Development and progression; Disease; Epithelial cells; Genetic aspects; Genetic transcription; Health aspects; Immunology; Inflammatory bowel disease; Interleukin-6; Medical research; Medicine, Experimental; Permeability; Plasma; Proteins; Ulcerative colitis; China; ulcerative colitis; IL-6; H3K27ac; STAT3

The aim of the present study was to investigate the effect of the IL-6/STAT3 signaling pathway on intestinal epithelial barrier injury in patients with ulcerative colitis (UC). Fifty-two patients with UC and 21 healthy subjects were recruited. The expression level of IL-6 in plasma was determined by...