Prominin-1 Localizes to the Open Rims of Outer Segment Lamellae in Xenopus laevis Rod and Cone Photoreceptors

• Published in: Investigative ophthalmology & visual science Vol. 53; no. 1; pp. 361 - 373
• Main Authors: Han, Zhou, Anderson, David W., Papermaster, David S.
• Format: Journal Article
• Language: English
• Published: United States Association for Research in Vision and Ophthalmology, Inc 01.01.2012
• Subjects: AC133 Antigen; Animals; Animals, Genetically Modified; Antibody Specificity; Antigens, CD - metabolism; Brain - metabolism; Eye Proteins - metabolism; Female; Fluorescent Antibody Technique, Indirect; Glycoproteins - metabolism; Green Fluorescent Proteins - metabolism; Immunoblotting; Kidney - metabolism; Microscopy, Electron; Peptide Fragments; Peptides - metabolism; Protein Processing, Post-Translational; Rabbits; Recombinant Fusion Proteins - metabolism; Retinal Cone Photoreceptor Cells - metabolism; Rod Cell Outer Segment - metabolism; Transgenes; Vision, Ocular - physiology; Xenopus laevis

Prominin-1 expresses in rod and cone photoreceptors. Mutations in the prominin-1 gene cause retinal degeneration in humans. In this study, the authors investigated the expression and subcellular localization of xlProminin-1 protein, the Xenopus laevis ortholog of prominin-1, in rod and cone photorec...