ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor α production

• Published in: The American journal of clinical nutrition Vol. 76; no. 2; pp. 454 - 459
• Main Authors: Grimble, Robert F, Howell, W. Martin, O'Reilly, Gillian, Turner, Stephen J, Markovic, Olivera, Hirrell, Sharon, East, J. Malcolm, Calder, Philip C
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.08.2002
• Subjects: Adult; adverse effects; anti-inflammatory activity; Biological and medical sciences; dietary supplements; Feeding. Feeding behavior; fish oils; Fish Oils - pharmacology; Fundamental and applied biological sciences. Psychology; genes; Genetics of eukaryotes. Biological and molecular evolution; homozygosity; Human; Humans; inflammation; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; lymphotoxin; Lymphotoxin-alpha - genetics; Male; men; Middle Aged; mononuclear leukocytes; Polymerase Chain Reaction; Polymorphism, Genetic; Population genetics, reproduction patterns; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - genetics; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Monocyte; Cytokine; Biosynthesis; Inflammation; Supplemented diet; Edible oil; Population genetics; Fish oil; Feeding; Animal oil; Tumor necrosis factor α; Polymorphism

Background: Tumor necrosis factor α (TNF-α) mediates inflammation. High TNF-α production has adverse effects during disease. Polymorphisms in the TNF-α and lymphotoxin α genes influence TNF-α production. Fish oil suppresses TNF-α production and has variable antiinflammatory effects on disease. Objec...