Distribution of angiotensin II receptor subtypes in rat and human kidney

• Published in: American journal of physiology. Renal physiology Vol. 262; no. 2 Pt 2; pp. F236 - F240
• Main Authors: Sechi, L A, Grady, E F, Griffin, C A, Kalinyak, J E, Schambelan, M
• Format: Journal Article
• Language: English
• Published: United States 01.02.1992
• Subjects: 1-Sarcosine-8-Isoleucine Angiotensin II - metabolism; Angiotensin II - antagonists & inhibitors; Angiotensin II - metabolism; Angiotensin Receptor Antagonists; Animals; Autoradiography; Binding, Competitive; Biphenyl Compounds - metabolism; Humans; Imidazoles - metabolism; Kidney - metabolism; Losartan; Male; Pyridines - metabolism; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin - metabolism; Tetrazoles - metabolism; Tissue Distribution

Angiotensin II initiates a variety of physiological effects in the kidney by binding to high-affinity receptors on plasma membranes. Recently, two subtypes of angiotensin II receptors have been distinguished on the basis of differences in signal transduction mechanisms, binding affinity to agonists...