The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor Complex

• Published in: The Journal of immunology (1950) Vol. 181; no. 4; pp. 2799 - 2805
• Main Authors: Wright, Jill F, Bennett, Frann, Li, Bilian, Brooks, Jonathan, Luxenberg, Deborah P, Whitters, Matthew J, Tomkinson, Kathleen N, Fitz, Lori J, Wolfman, Neil M, Collins, Mary, Dunussi-Joannopoulos, Kyri, Chatterjee-Kishore, Moitreyee, Carreno, Beatriz M
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.08.2008
• Subjects: Cell Line; Dimerization; Dose-Response Relationship, Immunologic; Humans; Interleukin-17 - antagonists & inhibitors; Interleukin-17 - chemistry; Interleukin-17 - metabolism; Interleukin-17 - physiology; Protein Binding - immunology; Receptors, Interleukin - metabolism; Receptors, Interleukin - physiology; Receptors, Interleukin-17 - metabolism; Receptors, Interleukin-17 - physiology; Signal Transduction - immunology

IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. We recently reported that activated human CD4(+) T cells produce not only IL-17A and IL-17F homodimers but also an IL-17F/IL-17A heterodimeric cytokine. All three c...