Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 71; no. 9; p. 1210
• Main Authors: Cantero, Jose L, Iglesias, Juan E, Van Leemput, Koen, Atienza, Mercedes
• Format: Journal Article
• Language: English
• Published: United States 01.09.2016
• Subjects: Aged; Aging; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - epidemiology; Amyloid beta-Peptides - blood; Atrophy; Biomarkers - blood; Brain - pathology; Cross-Sectional Studies; Diagnosis, Differential; Female; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Male; Memory Disorders - blood; Memory Disorders - diagnosis; Memory Disorders - epidemiology; Middle Aged; Neuropsychological Tests; Predictive Value of Tests; Sensitivity and Specificity; Aging; Biomarkers; Subjective memory complaints; Alzheimer’s disease; Plasma amyloid-beta; Hippocampus

Evidence suggests a link between the presence of subjective memory complaints (SMC) and lower volume of the hippocampus, one of the first regions to show neuropathological lesions in Alzheimer's disease. However, it remains unknown whether this pattern of hippocampal atrophy is regionally speci...