N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction

• Published in: The Journal of heart and lung transplantation Vol. 40; no. 6; pp. 447 - 457
• Main Authors: Banday, Mudassir M., Kumar, Archit, Vestal, Grant, Sethi, Jaskaran, Patel, Kapil N., O'Neill, Edward B., Finan, Jon, Cheng, Feng, Lin, Muling, Davis, Nicole M., Goldberg, Hilary, Coppolino, Antonio, Mallidi, Hari R., Dunning, John, Visner, Gary, Gaggar, Amit, Seyfang, Andreas, Sharma, Nirmal S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: Allografts; BOS; Chronic Disease; CLAD; Down-Regulation; dysbiosis; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Epithelial Cells - pathology; epithelial to mesenchymal transition; Epithelial-Mesenchymal Transition - genetics; Female; fibrogenesis; Follow-Up Studies; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins - biosynthesis; Intracellular Signaling Peptides and Proteins - genetics; Lung Transplantation - adverse effects; Male; microbiome; Microbiota; Middle Aged; Primary Graft Dysfunction - genetics; Primary Graft Dysfunction - microbiology; Primary Graft Dysfunction - pathology; Retrospective Studies; RNA, Ribosomal, 16S - genetics; CLAD; BOS; epithelial to mesenchymal transition; fibrogenesis; NMI; microbiome; BAL; EMT; LPS; dysbiosis; PsA

Recent evidence suggests a role for lung microbiome in occurrence of chronic lung allograft dysfunction (CLAD). However, the mechanisms linking the microbiome to CLAD are poorly delineated. We investigated a possible mechanism involved in microbial modulation of mucosal response leading to CLAD with...