Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR

• Published in: Advanced science Vol. 11; no. 40; pp. e2405459 - n/a
• Main Authors: Cao, Pengbo, Chen, Hongxia, Zhang, Ying, Zhang, Qi, Shi, Mengting, Han, Huihui, Wang, Xiaowen, Jin, Liang, Guo, Bingqian, Hao, Rongjiao, Zhao, Xi, Li, Yuanfeng, Gao, Chengming, Liu, Xinyi, Wang, Yahui, Yang, Aiqing, Yang, Chenning, Si, Anfeng, Li, Hua, Song, Qingfeng, He, Fuchu, Zhou, Gangqiao
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.10.2024; John Wiley and Sons Inc; Wiley
• Subjects: 8q24.13 amplification; Clinical outcomes; Datasets; epidermal growth factor receptor (EGFR) trafficking; Gene expression; hepatocellular carcinomas (HCCs); Kinases; lenvatinib; Liver cancer; Medical prognosis; Mutation; Proteins; Rab22A; TBC1D31; hepatocellular carcinomas (HCCs); epidermal growth factor receptor (EGFR) trafficking; TBC1D31; lenvatinib; 8q24.13 amplification; Rab22A

Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown. By performing a genome‐wide survey on prognosis‐associated focal CNAs in 814 HCC patients by an integrative computational framework...