Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops

• Published in: Advanced science Vol. 11; no. 34; pp. e2309473 - n/a
• Main Authors: Zheng, Kai‐Yu, Gao, Bo, Wang, Hua‐Jie, He, Jin‐Gang, Chen, Hong‐Sheng, Hu, Zhuang‐Li, Long, Li‐Hong, Chen, Jian‐Guo, Wang, Fang
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2024; John Wiley and Sons Inc; Wiley
• Subjects: Aging; Animals; Antidepressants; Behavior; Behavior, Animal - drug effects; Clinical trials; Colon; Depression - drug therapy; Depression - metabolism; Disease Models, Animal; Drinking water; Dysbiosis - drug therapy; Female; Females; Gastrointestinal Microbiome - drug effects; gut microbiota; Hormone replacement therapy; Melatonin; Melatonin - pharmacology; menopausal depression; Menopause; Mental depression; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Microbiota; Ovariectomy; Sucrose; Surgery; Tryptophan - metabolism; Tryptophan - pharmacology; tryptophans; menopausal depression; melatonin; gut microbiota; tryptophans

Melatonin (N‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition is altered during menopausal period. The possible role of microbiome in the treatment effect of melatonin on menopausal depression remains unknown. Here, it is shown...