Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects

• Published in: Clinical pharmacology in drug development Vol. 7; no. 2; pp. 188 - 195
• Main Authors: Nomoto, Maiko, Pastino, Gina, Rege, Bhaskar, Aluri, Jagadeesh, Ferry, Jim, Han, David
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2018
• Subjects: avatrombopag; ethnic differences; Pharmacodynamics; Pharmacokinetics; Pharmacology; platelet count; thrombocytopenia; White people; platelet count; pharmacokinetics; avatrombopag; thrombocytopenia; ethnic differences

Avatrombopag, an orally administered, small‐molecule thrombopoietin receptor (c‐Mpl) agonist, is currently in clinical development for the potential treatment of severe thrombocytopenia in patients with chronic liver disease undergoing an elective procedure. The objectives of this study were to char...