Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high‐fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib - Mohamed, Mohamed‐Eslam F.; Jungerwirth, Steven; Asatryan, Armen; Jiang, Ping; Othman, Ahmed A. (British journal of clinical pharmacology, 2017)
Keywords: Adult; Area Under Curve; Autoimmune Diseases - drug therapy; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inducers - pharmacokinetics; Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics; Diet, High-Fat; Dietary Fats - pharmacokinetics; Drug Interactions; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Heterocyclic Compounds, 3-Ring - pharmacology; Heterocyclic Compounds, 3-Ring - therapeutic use; high‐fat meal; Humans; JAK1 inhibitor; Janus Kinase 1 - antagonists & inhibitors; ketoconazole; Ketoconazole - pharmacokinetics; Liver-Specific Organic Anion Transporter 1 - antagonists & inhibitors; Male; Middle Aged; pharmacokinetics; Protein Kinase Inhibitors - pharmacology; rifampin; Rifampin - pharmacokinetics; upadacitinib; Young Adult; high-fat meal; upadacitinib; pharmacokinetics; JAK1 inhibitor; ketoconazole; rifampin