Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP‐5862, in patients with B‐cell malignancies and in healthy subjects using a population pharmacokinetic approach - Edlund, Helena; Bellanti, Francesco; Liu, Huan; Vishwanathan, Karthick; Tomkinson, Helen; Ware, Joseph; Sharma, Shringi; Buil‐Bruna, Núria (British journal of clinical pharmacology, 2022)
Keywords: acalabrutinib; ACP‐5862; Benzamides - pharmacokinetics; between‐occasion variability; B‐cell malignancies; Healthy Volunteers; Humans; Models, Biological; Neoplasms; pharmacokinetics; pH‐dependent solubility; population pharmacokinetics; Pyrazines - pharmacokinetics; Short Communication; Short Communications; pH-dependent solubility; between-occasion variability; pharmacokinetics; ACP-5862; B-cell malignancies; acalabrutinib; population pharmacokinetics