The AP‐1 pathway; A key regulator of cellular transformation modulated by oncogenic viruses

Summary Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B virus, hepatitis C virus,...

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Published inReviews in medical virology Vol. 30; no. 1; pp. e2088 - n/a
Main Authors Mirzaei, Habibollah, Khodadad, Nastaran, Karami, Chiman, Pirmoradi, Roya, Khanizadeh, Sayyad
Format Journal Article
LanguageEnglish
Published England Wiley Periodicals Inc 01.01.2020
Subjects
AP‐1
Cancer
Deregulation
Epstein-Barr virus
Hepatitis
Hepatitis B
Hepatitis C
Human papillomavirus
Kaposi's sarcoma
oncogenic viruses
Sarcoma
Signal transduction
Tumor viruses
Tumorigenesis
Viruses
AP-1
cancer
oncogenic viruses
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Abstract Summary Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein‐Barr virus, human T‐cell lymphotropic virus type 1, and Kaposi's sarcoma‐associated herpes virus, are common causes of cancer. This review discusses how these oncoviruses by acting through various aspects of the host cell signaling machinery such as the AP‐1 pathway might affect oncoviral tumorigenesis, replication, and pathogenesis. The review also briefly considers how the pathway might be targeted during infections with these oncogenic viruses.
AbstractList Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein-1 (AP-1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus type 1, and Kaposi's sarcoma-associated herpes virus, are common causes of cancer. This review discusses how these oncoviruses by acting through various aspects of the host cell signaling machinery such as the AP-1 pathway might affect oncoviral tumorigenesis, replication, and pathogenesis. The review also briefly considers how the pathway might be targeted during infections with these oncogenic viruses.
Summary Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway whose deregulation renders the host more susceptible to cancer development. Oncogenic viruses, including hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein‐Barr virus, human T‐cell lymphotropic virus type 1, and Kaposi's sarcoma‐associated herpes virus, are common causes of cancer. This review discusses how these oncoviruses by acting through various aspects of the host cell signaling machinery such as the AP‐1 pathway might affect oncoviral tumorigenesis, replication, and pathogenesis. The review also briefly considers how the pathway might be targeted during infections with these oncogenic viruses.
Author Khanizadeh, Sayyad
Khodadad, Nastaran
Pirmoradi, Roya
Mirzaei, Habibollah
Karami, Chiman
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  surname: Mirzaei
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  surname: Khodadad
  fullname: Khodadad, Nastaran
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  surname: Karami
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  surname: Khanizadeh
  fullname: Khanizadeh, Sayyad
  email: khanizadeh.s@lums.ac.ir
  organization: Lorestan University of Medical Sciences
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Keywords AP-1
cancer
oncogenic viruses
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Snippet Summary Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway...
Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein-1 (AP-1) signaling is one such pathway whose...
Cancer progression is critically associated with modulation of host cell signaling pathways. Activator protein‐1 (AP‐1) signaling is one such pathway whose...
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pubmed
wiley
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Publisher
StartPage e2088
SubjectTerms AP‐1
Cancer
Deregulation
Epstein-Barr virus
Hepatitis
Hepatitis B
Hepatitis C
Human papillomavirus
Kaposi's sarcoma
oncogenic viruses
Sarcoma
Signal transduction
Tumor viruses
Tumorigenesis
Viruses
Title The AP‐1 pathway; A key regulator of cellular transformation modulated by oncogenic viruses
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Frmv.2088
https://www.ncbi.nlm.nih.gov/pubmed/31788897
https://www.proquest.com/docview/2337695467
https://search.proquest.com/docview/2320641014
Volume 30
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