Sensitivity of estimated tacrolimus population pharmacokinetic profile to assumed dose timing and absorption in real‐world data and simulated data

• Published in: British journal of clinical pharmacology Vol. 88; no. 6; pp. 2863 - 2874
• Main Authors: Williams, Michael L., Weeks, Hannah L., Beck, Cole, Birdwell, Kelly A., Van Driest, Sara L., Choi, Leena
• Format: Journal Article
• Language: English
• Published: England 01.06.2022
• Subjects: absorption; biostatistics; Computer Simulation; Half-Life; Humans; Models, Biological; Research Design; Tacrolimus - pharmacokinetics; therapeutic drug monitoring; biostatistics; absorption; therapeutic drug monitoring
• ISSN: 0306-5251; 1365-2125; 1365-2125
• DOI: 10.1111/bcp.15218

Aims Use of electronic health record (EHR) data to estimate population pharmacokinetic (PK) profiles necessitates several assumptions. We sought to investigate sensitivity to some of these assumptions about dose timing and absorption rates. Methods A population PK study with 363 subjects was perform...