Redox regulation by SOD2 modulates colorectal cancer tumorigenesis through AMPK‐mediated energy metabolism

• Published in: Molecular carcinogenesis Vol. 59; no. 5; pp. 545 - 556
• Main Authors: Zhou, Chen, Lyu, Li‐hua, Miao, Hui‐kai, Bahr, Tyler, Zhang, Qiong‐ying, Liang, Ting, Zhou, Huai‐bin, Chen, Guo‐rong, Bai, Yidong
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2020
• Subjects: AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Antioxidants; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell migration; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Colorectal cancer; colorectal cancer (CRC); Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Disease Progression; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glycolysis; Homeostasis; Humans; Hydrogen peroxide; Malignancy; Manganese; manganese superoxide dismutase (MnSOD/SOD2); Metabolism; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - pathology; Oxidation-Reduction; Oxidative Stress; Prognosis; Reactive Oxygen Species - metabolism; redox; Superoxide dismutase; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Tumor Cells, Cultured; Tumorigenesis; colorectal cancer (CRC); manganese superoxide dismutase (MnSOD/SOD2); glycolysis; redox

Colorectal cancer (CRC) is a common malignancy. Many reports have implicated aberrant mitochondrial activity in the progression of CRC, with particular emphasis on the dysregulation of redox signaling and oxidative stress. In this study, we focused on manganese superoxide dismutase (MnSOD/SOD2), a k...