Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography–tandem mass spectrometry

• Published in: Journal of separation science Vol. 43; no. 16; pp. 3183 - 3196
• Main Authors: Sun, Lu‐Ning, Zhang, Ye, Yang, Yu‐Qing, Shen, Ye, Ying, Yu‐Wen, Su, Yu‐Wen, Zhang, Xue‐Hui, Liu, Yun, Huang, Xu, Wang, Yong‐Qing
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.08.2020
• Subjects: acetates; Acetic acid; Acetonitrile; Ammonia; Ammonium acetate; Blood plasma; chemical species; chiral liquid chromatography/enantiomers; Chromatography; dialysis; Enantiomers; enantioselectivity; humans; Inhibitors; Ions; isotope labeling; lansoprazole; Liquid chromatography; Mass spectrometry; protein binding; proton pump; proton pump inhibitors; Protons; Scientific imaging; separation; spectrometers; Spectroscopy; tandem mass spectrometry

Proton pump inhibitors, including omeprazole, rabeprazole, lansoprazole, and pantoprazole, achieved simultaneous enantioselective determination in the human plasma by chiral liquid chromatography–tandem mass spectrometry. The four corresponding stable isotope‐labeled proton pump inhibitors were adop...