Long‐term survivors of early breast cancer treated with chemotherapy are characterized by a pro‐inflammatory biomarker profile compared to matched controls

• Published in: European journal of heart failure Vol. 22; no. 7; pp. 1239 - 1246
• Main Authors: Tromp, Jasper, Boerman, Liselotte M., Sama, Iziah E., Maass, Saskia W.M.C., Maduro, John H., Hummel, Yoran M., Berger, Marjolein Y., Bock, Geertruida H., Gietema, Jourik A., Berendsen, Annette J., Meer, Peter
• Format: Journal Article
• Language: English
• Published: Oxford, UK John Wiley & Sons, Ltd 01.07.2020
• Subjects: Aged; Biomarkers; Breast Neoplasms - drug therapy; Cardiotoxicity; CARDIO‐ONCOLOGY; Female; Heart Failure; Humans; Middle Aged; Pathophysiology; Stroke Volume; Survivors; Ventricular Function, Left; Biomarkers; Cardio-oncology; Cardiotoxicity; Pathophysiology

Background Chemo‐ and radiotherapy for breast cancer (BC) can lead to cardiotoxicity even years after the initial treatment. The pathophysiology behind these late cardiac effects is poorly understood. Therefore, we studied a large panel of biomarkers from different pathophysiological domains in long...