Cell viability and cytotoxicity assays: Biochemical elements and cellular compartments

Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In...

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Published inCell biochemistry and function Vol. 42; no. 3; pp. e4007 - n/a
Main Authors Khalef, Lefsih, Lydia, Radja, Filicia, Khettar, Moussa, Berkoud
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.04.2024
Subjects
Adenosine
Assaying
Assessments
Biochemistry
Biomolecules
Cell adhesion
Cell death
Cell membranes
Cell survival
Cell viability
Classification
Compartments
Cytotoxicity
cytotoxicity assay
DNA fragmentation
Drug development
Drug screening
Enzymatic activity
Enzyme activity
Evaluation
Membrane permeability
Mortality
Reliability analysis
Toxicity
cell death
cytotoxicity assay
cell viability
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Abstract Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5′‐triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost‐effective, and high‐throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process. Significance statement Various perspectives exist regarding the definitions of cell viability, cell death, and cytotoxicity. This review article aims to provide an up‐to‐date classification of commonly used in vitro cytotoxicity assays. The goal is to provide an in‐depth exploration of their underlying principles, the biochemical components involved, the specific cellular compartments targeted, and a comprehensive analysis of their respective strengths and limitations. Potential false positive results exists in cytotoxicity assessments. For instance, when there is a decrease in viability following a proliferation assay, the utilization of mandatory cell death confirmation assays. Therefore, meticulous consideration of the specific mechanisms underlying cell death, along with the incorporation of appropriate confirmation assays, becomes imperative in ensuring the accuracy and reliability of cytotoxicity assessments.
AbstractList Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5′‐triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost‐effective, and high‐throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process.
Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5′‐triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost‐effective, and high‐throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process. Significance statement Various perspectives exist regarding the definitions of cell viability, cell death, and cytotoxicity. This review article aims to provide an up‐to‐date classification of commonly used in vitro cytotoxicity assays. The goal is to provide an in‐depth exploration of their underlying principles, the biochemical components involved, the specific cellular compartments targeted, and a comprehensive analysis of their respective strengths and limitations. Potential false positive results exists in cytotoxicity assessments. For instance, when there is a decrease in viability following a proliferation assay, the utilization of mandatory cell death confirmation assays. Therefore, meticulous consideration of the specific mechanisms underlying cell death, along with the incorporation of appropriate confirmation assays, becomes imperative in ensuring the accuracy and reliability of cytotoxicity assessments.
Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5'-triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost-effective, and high-throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process.Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5'-triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost-effective, and high-throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process.
Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability and cytotoxicity based on morphological, biochemical, and functional perspectives. As this domain continues to experience ongoing growth, revealing new mechanisms orchestrating diverse cell cytotoxicity pathways, we suggest a revised classification for multiple assays employed in evaluating cell viability and cell death. This classification is rooted in the cellular compartment and/or biochemical element involved, with a specific focus on mechanistic and essential aspects of the process. The assays are founded on diverse cell functions, encompassing metabolic activity, enzyme activity, cell membrane permeability and integrity, adenosine 5′‐triphosphate content, cell adherence, reduction equivalents, dye inclusion or exclusion, constitutive protease activity, colony formation, DNA fragmentation and nuclear splitting. These assays present straightforward, reliable, sensitive, reproducible, cost‐effective, and high‐throughput approaches for appraising the effects of newly formulated chemotherapeutic biomolecules on the cell survival during the drug development process. Various perspectives exist regarding the definitions of cell viability, cell death, and cytotoxicity. This review article aims to provide an up‐to‐date classification of commonly used in vitro cytotoxicity assays. The goal is to provide an in‐depth exploration of their underlying principles, the biochemical components involved, the specific cellular compartments targeted, and a comprehensive analysis of their respective strengths and limitations. Potential false positive results exists in cytotoxicity assessments. For instance, when there is a decrease in viability following a proliferation assay, the utilization of mandatory cell death confirmation assays. Therefore, meticulous consideration of the specific mechanisms underlying cell death, along with the incorporation of appropriate confirmation assays, becomes imperative in ensuring the accuracy and reliability of cytotoxicity assessments.
Author Khalef, Lefsih
Lydia, Radja
Filicia, Khettar
Moussa, Berkoud
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  organization: Université Mouloud Mammeri de Tizi ouzou
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  givenname: Radja
  surname: Lydia
  fullname: Lydia, Radja
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  surname: Filicia
  fullname: Filicia, Khettar
  organization: Université Mouloud Mammeri de Tizi ouzou
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  givenname: Berkoud
  surname: Moussa
  fullname: Moussa, Berkoud
  organization: Université Mouloud Mammeri de Tizi ouzou
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38593323$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1146/annurev.physiol.60.1.619
10.1099/jmm.0.46915-0
10.21769/BioProtoc.1984
10.1007/978-1-4614-8220-8_18
10.3390/pharmaceutics15020612
10.1146/annurev-anchem-062011-143134
10.1016/j.devcel.2020.09.029
10.2174/1570163815666180925095433
10.3727/095535491820873191
10.1016/j.cbi.2019.108868
10.1007/BF02618887
10.3168/jds.S0022-0302(50)91981-3
10.2131/jts.42.569
10.1038/nrd3373
10.1002/cyto.a.20012
10.1016/0165-1161(87)90011-2
10.1016/S0037-1963(01)90051-4
10.1292/jvms.65.1161
10.1080/17435390902788086
10.1016/j.eururo.2005.12.043
10.1016/j.ab.2004.02.007
10.1002/cbdv.202201098
10.17305/bjbms.2018.3323
10.1016/j.phytochem.2018.06.015
10.1074/jbc.M203080200
10.7314/APJCP.2013.14.9.5461
10.1016/0006-3002(63)90513-4
10.3181/00379727-98-23985
10.1021/bc034189q
10.1101/pdb.prot087205
10.1038/nprot.2006.339
10.1517/17460441.3.6.655
10.1021/nl047996m
10.1046/j.1432-1327.2000.01606.x
10.1021/bi047374f
10.1038/s41596-021-00615-0
10.1248/bpb.19.1518
10.1016/0022-1759(86)90215-2
10.1016/j.mimet.2012.03.005
10.1021/nn800596w
10.1002/cmdc.201600629
10.1097/00007890-196411000-00001
10.1016/S0142-9612(02)00445-3
10.1016/j.ymeth.2013.02.011
10.1021/acs.accounts.9b00289
10.1007/s004180050402
10.1002/cyto.990130802
10.1016/j.yrtph.2018.06.003
10.2307/3578650
10.1093/jnci/82.13.1107
10.1002/(SICI)1097-0320(19991101)37:3<197::AID-CYTO6>3.0.CO;2-L
10.1016/S0003-9861(02)00217-5
10.1016/S0014-4827(85)80052-5
10.1385/1-59259-869-2:039
10.1007/978-1-61779-080-5_19
10.1053/sarh.2003.50005
10.1016/j.bbamcr.2020.118787
10.1016/0003-2697(86)90314-3
10.1021/nl801661w
10.15419/ajhs.v8i2.514
10.1016/j.sjbs.2012.12.002
10.1016/B978-012529650-2/50047-0
10.3390/ijms222312827
10.1016/S0022-1759(02)00437-4
10.1096/fj.02-0142fje
10.1385/MB:26:3:249
10.1016/S0002-9440(10)65001-8
10.3389/fimmu.2019.03030
10.1038/srep15348
10.1146/annurev.cellbio.21.012704.131040
10.1016/j.ymeth.2009.02.016
10.1016/j.ab.2015.09.010
10.1038/cdd.2009.185
10.1016/0014-4827(70)90573-2
10.1021/pr300018c
10.1016/j.smim.2014.10.001
10.20892/j.issn.2095-3941.2021.0504
10.3390/chemosensors6020018
10.1016/0009-2797(77)90154-5
10.1590/S1806-83242009000300006
10.15171/bi.2015.01
10.1007/978-1-61779-108-6_12
10.1371/journal.pone.0091558
10.1091/mbc.12.6.1569
10.1002/path.1711700102
10.1016/j.cgh.2020.06.008
10.1016/j.bbcan.2016.10.002
10.1128/CDLI.8.6.1131-1135.2001
10.5455/jrmds.2017526
10.1371/journal.pone.0028338
10.4049/jimmunol.148.7.2207
10.1093/nar/gkg308
10.1002/fft2.44
10.2174/1871520621999201230202614
10.1007/978-3-7091-0885-7_15
10.1038/15690
10.1016/S0887-2333(97)00107-0
10.1016/S1383-5718(02)00251-6
10.1007/978-1-59745-339-4_12
10.1002/cptx.21
10.1161/01.CIR.99.21.2757
10.1038/s41598-021-97894-0
10.1016/0921-8777(94)00043-6
10.1016/j.etap.2007.03.001
10.1177/002215549904700614
10.1089/adt.2005.3.675
10.1371/journal.pone.0126313
10.1385/1-59259-687-8:17
10.1016/0014-4827(53)90094-9
10.1007/978-1-61779-108-6_7
10.1177/096032719501401201
10.1002/0471142735.ima03bs21
10.5772/intechopen.71923
10.1016/j.acthis.2018.02.005
10.1007/BF01962793
10.1038/nprot.2006.179
10.1002/smll.200600218
10.1016/S0753-3322(98)80010-3
10.1007/978-1-61779-860-3_5
10.1007/s00784-012-0792-3
10.1097/CAD.0000000000001131
10.1158/0008-5472.CAN-03-2630
10.1093/humrep/dem011
10.1038/cdd.2009.44
10.1016/j.cgh.2020.04.001
10.1007/978-1-61779-108-6_2
10.1182/blood.V84.5.1415.bloodjournal8451415
10.1128/AEM.68.11.5728-5736.2002
10.1016/S0006-291X(02)00587-9
10.1042/CBI20100083
10.1042/bj3080591
10.1016/j.ab.2007.04.007
10.1016/0022-1759(83)90438-6
10.1007/s10495-022-01735-y
10.1093/mutage/gep027
10.1016/j.drup.2010.09.001
10.3389/fcell.2021.645593
10.1002/(SICI)1097-0320(19971101)29:3<191::AID-CYTO1>3.0.CO;2-F
10.1007/s11033-018-4258-9
10.1186/1743-8977-8-8
10.1016/0022-1759(93)90011-U
10.1007/s10541-005-0104-5
10.1016/0959-8049(93)90297-S
10.1002/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R
10.1080/01926230701320337
10.1080/15376516.2019.1566424
10.3329/bjp.v12i2.30892
10.1371/journal.pntd.0000759
10.2174/1389201017666160808160513
10.1111/1567-1364.12202
10.14293/genint.14.1.001
10.1016/0014-4827(68)90475-8
10.1128/JCM.41.1.506-508.2003
10.1385/1-59259-869-2:069
10.1038/nprot.2008.75
10.1016/j.jim.2010.03.019
10.1016/S0027-5107(01)00123-3
10.1038/cddiscovery.2016.101
10.1053/j.gastro.2020.02.055
10.1016/0003-2697(90)90310-6
10.1007/BF01666038
10.1023/A:1018729308878
10.1016/j.biomaterials.2007.02.034
10.1016/j.btre.2015.04.004
10.1186/s12943-016-0517-3
10.1083/jcb.119.3.493
10.1016/j.brainresrev.2006.08.002
10.1016/j.jss.2006.07.034
10.1039/c1pp05014a
10.1016/S0361-090X(02)00171-X
10.1016/0022-1759(83)90303-4
10.1016/0014-4827(88)90265-0
10.1016/0022-1759(95)00072-I
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wiley_primary_10_1002_cbf_4007_CBF4007
ProviderPackageCode CITATION
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PublicationCentury 2000
PublicationDate April 2024
2024-04-00
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PublicationDateYYYYMMDD 2024-04-01
PublicationDate_xml – month: 04
  year: 2024
  text: April 2024
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Bognor Regis
PublicationTitle Cell biochemistry and function
PublicationTitleAlternate Cell Biochem Funct
PublicationYear 2024
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References 2002; 16
1979; 35
1993; 29
2010; 13
2010; 17
2004; 26
2013; 61
1999; 47
2020; 17
2014; 26
2011; 54
2016; 2016
2020; 10
2022; 22
2004; 329
2018; 45
2003; 278
2012; 11
1990; 185
2022; 27
2003; 274
2020; 18
2017; 72
1987; 47
2018; 6
1950; 33
1963; 77
2000; 16
2010; 358
2022; 40
2014; 14
2019; 29
1992; 119
2020; 1867
2005; 70
1988; 175
2022; 33
1993; 136
2003; 41
2010; 4
2009; 16
1998; 12
1968; 52
1986; 94
2006; 50
1996; 19
2005; 110
1997; 21
1992; 148
2012; 508
1997; 29
1953; 5
1998; 60
2018; 23
2016; 17
2011; 6
2016; 15
2011; 8
2003; 31
1995; 5
1994; 84
2003; 32
1999
2014; 545
2018; 18
2016; 6
2006; 42
2010; 48
1977; 16
2004; 58
1995; 308
2022; 8
2002; 68
1999; 37
2005; 5
2003; 24
2002; 403
2003; 27
2020; 315
1985; 159
2001; 38
2005; 3
2020; 158
1999; 112
2018; 97
2005; 11
1987; 182
1964; 2
2018; 120
2017; 5
2017; 42
2004; 64
2017; 3
2021; 22
2019; 52
2008a
2013; 20
1993; 160
1958; 98
1995; 336
2005; 21
2008; 8
2011; 10
1992; 13
2020; 55
2008; 3
2007; 35
2009; 48
2007; 28
2023; 20
2013; 14
2013; 17
2020; 1
2007; 139
2000
1988; 48
1983; 64
2003; 2
1983; 65
1999; 99
1970; 62
1993; 170
2014; 9
1998; 52
2001; 12
2007; 22
2007; 24
2009; 23
2021; 9
1991; 3
2009; 25
2007; 366
2009; 24
2015; 5
2023; 14
2003; 534
1986; 159
2012
2011
2023; 15
2002; 294
1995; 14
1985; 9
2015; 10
2016; 1866
2008; 446
2011; 35
2005
1999; 4
2004
2006; 1
2006; 2
2000; 156
1999; 1
2007; 53
2001; 66
1985; 45
1972; 7
2015; 7
2007; 56
2005; 44
1990; 82
2021; 16
2008b; 3
2018; 154
2018; 2018
2021; 11
2023
2000; 267
2022
2004; 15
2017; 12
2021; 19
2001; 8
1983; 43
2017
2014
2013
2009; 3
2012; 89
1995; 184
2012; 5
1998; 31
2001; 478
2003; 65
2016; 492
e_1_2_9_79_1
e_1_2_9_94_1
e_1_2_9_10_1
e_1_2_9_56_1
e_1_2_9_33_1
Naseer MI (e_1_2_9_45_1) 2009; 25
e_1_2_9_71_1
e_1_2_9_107_1
e_1_2_9_122_1
e_1_2_9_145_1
Henriksson E (e_1_2_9_60_1) 2006; 42
e_1_2_9_18_1
e_1_2_9_183_1
e_1_2_9_160_1
e_1_2_9_22_1
e_1_2_9_68_1
e_1_2_9_83_1
e_1_2_9_6_1
e_1_2_9_119_1
e_1_2_9_134_1
e_1_2_9_157_1
e_1_2_9_195_1
e_1_2_9_172_1
e_1_2_9_72_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_95_1
Johnston G (e_1_2_9_96_1) 2010; 48
e_1_2_9_129_1
e_1_2_9_144_1
e_1_2_9_167_1
e_1_2_9_106_1
e_1_2_9_121_1
e_1_2_9_19_1
e_1_2_9_182_1
Agarwal A (e_1_2_9_93_1) 2022; 40
e_1_2_9_61_1
e_1_2_9_46_1
e_1_2_9_84_1
e_1_2_9_23_1
e_1_2_9_5_1
e_1_2_9_118_1
e_1_2_9_133_1
e_1_2_9_156_1
e_1_2_9_179_1
Özlem Sultan A. (e_1_2_9_188_1) 2017
e_1_2_9_69_1
e_1_2_9_110_1
e_1_2_9_171_1
e_1_2_9_194_1
e_1_2_9_31_1
e_1_2_9_77_1
e_1_2_9_54_1
e_1_2_9_92_1
e_1_2_9_109_1
e_1_2_9_101_1
e_1_2_9_124_1
e_1_2_9_147_1
e_1_2_9_39_1
e_1_2_9_162_1
e_1_2_9_16_1
e_1_2_9_185_1
e_1_2_9_20_1
e_1_2_9_89_1
e_1_2_9_43_1
e_1_2_9_66_1
e_1_2_9_81_1
e_1_2_9_113_1
e_1_2_9_159_1
e_1_2_9_136_1
e_1_2_9_151_1
e_1_2_9_197_1
e_1_2_9_28_1
e_1_2_9_174_1
Weisenthal LM (e_1_2_9_90_1) 1983; 43
e_1_2_9_78_1
e_1_2_9_32_1
e_1_2_9_55_1
Alamoudi WA (e_1_2_9_111_1) 2018; 23
e_1_2_9_108_1
e_1_2_9_70_1
e_1_2_9_100_1
Anil S (e_1_2_9_8_1) 2023
e_1_2_9_123_1
e_1_2_9_169_1
e_1_2_9_146_1
e_1_2_9_17_1
e_1_2_9_184_1
Scudiero DA (e_1_2_9_2_1) 1988; 48
e_1_2_9_21_1
e_1_2_9_67_1
e_1_2_9_44_1
e_1_2_9_7_1
e_1_2_9_82_1
Carmichael J (e_1_2_9_53_1) 1987; 47
e_1_2_9_112_1
e_1_2_9_135_1
e_1_2_9_158_1
e_1_2_9_173_1
e_1_2_9_196_1
e_1_2_9_29_1
e_1_2_9_150_1
e_1_2_9_75_1
e_1_2_9_98_1
e_1_2_9_190_1
Raza A (e_1_2_9_117_1) 1985; 45
e_1_2_9_103_1
e_1_2_9_126_1
e_1_2_9_149_1
e_1_2_9_14_1
e_1_2_9_141_1
e_1_2_9_187_1
e_1_2_9_37_1
e_1_2_9_164_1
e_1_2_9_41_1
e_1_2_9_64_1
e_1_2_9_87_1
e_1_2_9_138_1
e_1_2_9_115_1
e_1_2_9_199_1
e_1_2_9_26_1
e_1_2_9_49_1
e_1_2_9_130_1
e_1_2_9_176_1
e_1_2_9_153_1
e_1_2_9_191_1
e_1_2_9_99_1
e_1_2_9_91_1
e_1_2_9_102_1
e_1_2_9_148_1
e_1_2_9_125_1
e_1_2_9_38_1
e_1_2_9_140_1
e_1_2_9_163_1
e_1_2_9_186_1
Kumar P (e_1_2_9_76_1) 2018; 2018
e_1_2_9_42_1
e_1_2_9_88_1
Pop C (e_1_2_9_30_1) 2008
Marshall NJ (e_1_2_9_58_1) 1995; 5
e_1_2_9_65_1
e_1_2_9_80_1
Eslin Ustun K (e_1_2_9_15_1) 2022
e_1_2_9_114_1
e_1_2_9_137_1
e_1_2_9_9_1
e_1_2_9_152_1
e_1_2_9_175_1
e_1_2_9_198_1
e_1_2_9_27_1
Srinivasula SM (e_1_2_9_139_1) 2001
e_1_2_9_50_1
e_1_2_9_73_1
e_1_2_9_35_1
e_1_2_9_12_1
Degterev A (e_1_2_9_40_1) 2014
Berridge MV (e_1_2_9_52_1) 2005
e_1_2_9_128_1
e_1_2_9_166_1
e_1_2_9_105_1
e_1_2_9_189_1
e_1_2_9_120_1
e_1_2_9_143_1
e_1_2_9_181_1
e_1_2_9_62_1
Alamoudi WA (e_1_2_9_25_1) 2018; 23
e_1_2_9_24_1
e_1_2_9_85_1
Barbisan LF (e_1_2_9_161_1) 2003; 2
e_1_2_9_4_1
e_1_2_9_155_1
e_1_2_9_178_1
e_1_2_9_132_1
e_1_2_9_193_1
Fang IJ (e_1_2_9_86_1) 2012
e_1_2_9_170_1
e_1_2_9_74_1
e_1_2_9_51_1
e_1_2_9_13_1
e_1_2_9_97_1
Honda O (e_1_2_9_168_1) 2000; 16
e_1_2_9_127_1
e_1_2_9_104_1
e_1_2_9_36_1
e_1_2_9_59_1
e_1_2_9_142_1
e_1_2_9_165_1
e_1_2_9_180_1
e_1_2_9_63_1
e_1_2_9_3_1
Vega‐Avila E (e_1_2_9_47_1) 2011; 54
e_1_2_9_116_1
e_1_2_9_177_1
e_1_2_9_131_1
e_1_2_9_154_1
e_1_2_9_48_1
e_1_2_9_192_1
References_xml – start-page: Ch. 3
  year: 2022
– volume: 99
  start-page: 2757
  issue: 21
  year: 1999
  end-page: 2764
  article-title: Significance of myocytes with positive DNA in situ nick end‐labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair
  publication-title: Circulation
– volume: 48
  start-page: 46
  issue: 1
  year: 2009
  end-page: 53
  article-title: The comet assay: a sensitive method for detecting DNA damage in individual cells
  publication-title: Methods
– volume: 35
  start-page: 1475
  year: 1979
  end-page: 1476
  article-title: The pharmacological relevance of vital staining with neutral red
  publication-title: Experientia
– volume: 2018
  start-page: 465
  issue: 6
  year: 2018
  end-page: 468
  article-title: Analysis of cell viability by the lactate dehydrogenase assay
  publication-title: Cold Spring Harb Protoc
– volume: 534
  start-page: 15
  issue: 1
  year: 2003
  end-page: 20
  article-title: A cross‐platform public domain PC image‐analysis program for the comet assay
  publication-title: Mutat Res
– volume: 13
  start-page: 795
  issue: 8
  year: 1992
  end-page: 808
  article-title: Features of apoptotic cells measured by flow cytometry
  publication-title: Cytometry
– start-page: 39
  year: 2005
  end-page: 48
– volume: 52
  start-page: 2147
  issue: 8
  year: 2019
  end-page: 2157
  article-title: Fluorescent probes for the visualization of cell viability
  publication-title: Acc Chem Res
– volume: 403
  start-page: 160
  issue: 2
  year: 2002
  end-page: 170
  article-title: Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N‐terminal amino group of synthetic substrates for enzyme activity
  publication-title: Arch Biochem Biophys
– volume: 6
  issue: 21
  year: 2016
  article-title: Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation
  publication-title: BIO‐PROTOCOL
– volume: 42
  start-page: 569
  issue: 5
  year: 2017
  end-page: 577
  article-title: Development of a modified 3T3 neutral red uptake phototoxicity test protocol for evaluation of poorly water‐soluble substances
  publication-title: J Toxicol Sci
– volume: 3
  start-page: 655
  issue: 6
  year: 2008b
  end-page: 669
  article-title: Update on cytotoxicity assays for drug development
  publication-title: Expert Opin Drug Discovery
– volume: 16
  start-page: 1456
  issue: 11
  year: 2002
  end-page: 1457
  article-title: 3H‐thymidine is a defective tool with which to measure rates of DNA synthesis
  publication-title: FASEB J
– start-page: 103
  year: 2011
  end-page: 114
– volume: 5
  start-page: 69
  issue: 2
  year: 1995
  end-page: 84
  article-title: A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function
  publication-title: Growth Regul
– volume: 11
  issue: 1
  year: 2021
  article-title: Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models
  publication-title: Sci Rep
– volume: 35
  start-page: 335
  issue: 4
  year: 2011
  end-page: 343
  article-title: Kojic acid, a secondary metabolite from Aspergillus sp., acts as an inducer of macrophage activation
  publication-title: Cell Biol Int
– volume: 158
  start-page: 1831
  issue: 6
  year: 2020
  end-page: 1833.e3
  article-title: Evidence for gastrointestinal infection of SARS‐CoV‐2
  publication-title: Gastroenterology
– volume: 64
  start-page: 313
  issue: 3
  year: 1983
  end-page: 320
  article-title: An enzyme‐release assay for natural cytotoxicity
  publication-title: J Immunol Methods
– volume: 44
  start-page: 9785
  issue: 28
  year: 2005
  end-page: 9794
  article-title: Association of the minor groove binding drug Hoechst 33258 with d (CGCGAATTCGCG) 2: volumetric, calorimetric, and spectroscopic characterizations
  publication-title: Biochemistry
– volume: 119
  start-page: 493
  issue: 3
  year: 1992
  end-page: 501
  article-title: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
  publication-title: J Cell Biol
– volume: 72
  start-page: 2.26.1
  issue: 1
  year: 2017
  end-page: 2.26.10
  article-title: Quantification of lactate dehydrogenase for cell viability testing using cell lines and primary cultured astrocytes
  publication-title: Curr Protoc Toxicol
– volume: 10
  issue: 6
  year: 2015
  article-title: Differential effects of cold atmospheric plasma in the treatment of malignant glioma
  publication-title: PLoS One
– volume: 110
  start-page: 69
  year: 2005
  end-page: 78
– volume: 20
  issue: 2
  year: 2023
  article-title: Cytotoxic activity of herbal medicines as assessed : a review
  publication-title: Chem Biodiversity
– volume: 1
  start-page: 1112
  issue: 3
  year: 2006
  end-page: 1116
  article-title: Sulforhodamine B colorimetric assay for cytotoxicity screening
  publication-title: Nat Protoc
– volume: 2016
  issue: 9
  year: 2016
  article-title: Analyzing cell death by nuclear staining with Hoechst 33342
  publication-title: Cold Spring Harb Protoc
– start-page: 631
  year: 2000
  end-page: 651
– volume: 10
  start-page: 221
  issue: 3
  year: 2011
  end-page: 237
  article-title: Cell death assays for drug discovery
  publication-title: Nat Rev Drug Discovery
– volume: 12
  start-page: 115
  issue: 2
  year: 2017
  end-page: 118
  article-title: MTT assay to evaluate the cytotoxic potential of a drug
  publication-title: Bangladesh Journal of Pharmacology
– volume: 28
  start-page: 2946
  issue: 19
  year: 2007
  end-page: 2958
  article-title: The effect of nano‐ and micron‐sized particles of cobalt–chromium alloy on human fibroblasts
  publication-title: Biomaterials
– volume: 7
  start-page: 323
  issue: 6
  year: 1972
  end-page: 329
  article-title: The dye‐exclusion test for cell viability: persistence of differential staining following fixation
  publication-title: In Vitro
– volume: 159
  start-page: 235
  issue: 1
  year: 1985
  end-page: 246
  article-title: Measurement of cell proliferation in microculture using hoechst 33342 for the rapid semiautomated microfluorimetric determination of chromatin DNA
  publication-title: Exp Cell Res
– volume: 56
  start-page: 733
  issue: 6
  year: 2007
  end-page: 737
  article-title: Use of a colorimetric assay to measure differences in cytotoxicity of mycobacterium tuberculosis strains
  publication-title: J Med Microbiol
– volume: 13
  start-page: 172
  issue: 6
  year: 2010
  end-page: 179
  article-title: Apoptosis assays for quantifying the bioactivity of anticancer drug products
  publication-title: Drug Resist Updates
– volume: 184
  start-page: 39
  issue: 1
  year: 1995
  end-page: 51
  article-title: A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
  publication-title: J Immunol Methods
– volume: 3
  start-page: 675
  issue: 6
  year: 2005
  end-page: 682
  article-title: Optimization, application, and interpretation of lactate dehydrogenase measurements in microwell determination of cell number and toxicity
  publication-title: Assay Drug Dev Technol
– volume: 6
  issue: 2
  year: 2018
  article-title: The use of hoechst dyes for DNA staining and beyond
  publication-title: Chemosensors
– volume: 308
  start-page: 591
  issue: 2
  year: 1995
  end-page: 598
  article-title: Ca2+ concentration during binding determines the manner in which annexin V binds to membranes
  publication-title: Biochem J
– volume: 24
  start-page: 98
  issue: 2
  year: 2007
  end-page: 105
  article-title: Modulatory effects of curcumin on γ‐radiation‐induced cellular damage in primary culture of isolated rat hepatocytes
  publication-title: Environ Toxicol Pharmacol
– volume: 3
  start-page: 279
  issue: 2
  year: 2009
  end-page: 290
  article-title: Cytotoxicity and genotoxicity of silver nanoparticles in human cells
  publication-title: ACS Nano
– volume: 1
  start-page: 2315
  issue: 5
  year: 2006
  end-page: 2319
  article-title: Clonogenic assay of cells
  publication-title: Nat Protoc
– volume: 22
  issue: 23
  year: 2021
  article-title: The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single‐cell analysis
  publication-title: Int J Mol Sci
– volume: 2
  start-page: 295
  issue: 3
  year: 2003
  end-page: 308
  article-title: Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine
  publication-title: Genet Mol Res
– volume: 10
  start-page: 822
  issue: 5
  year: 2011
  end-page: 831
  article-title: Targeted photodynamic therapy of breast cancer cells using antibody‐phthalocyanine‐gold nanoparticle conjugates
  publication-title: Photochem Photobiol Sci
– volume: 9
  start-page: 7
  issue: 1
  year: 1985
  end-page: 9
  article-title: A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR‐90
  publication-title: J Tissue Cult Methods
– volume: 1
  start-page: 332
  issue: 3
  year: 2020
  end-page: 349
  article-title: Guidelines for cell viability assays
  publication-title: Food Frontiers
– volume: 47
  start-page: 837
  issue: 6
  year: 1999
  end-page: 839
  article-title: Improved detection of apoptotic cells using a modified in situ TUNEL technique
  publication-title: J Histochem Cytochem
– volume: 508
  start-page: 41
  year: 2012
  end-page: 59
– volume: 40
  start-page: 228
  issue: 2
  year: 2022
  article-title: Sperm vitality and necrozoospermia: diagnosis, management, and results of a global survey of clinical practice
  publication-title: WJMH
– volume: 54
  start-page: 10
  year: 2011
  end-page: 14
  article-title: An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells
  publication-title: Proc West Pharmacol Soc
– volume: 16
  start-page: 1093
  issue: 8
  year: 2009
  end-page: 1107
  article-title: Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
  publication-title: Cell Death Differ
– volume: 26
  start-page: 249
  issue: 3
  year: 2004
  end-page: 261
  article-title: The comet assay for DNA damage and repair
  publication-title: Mol Biotechnol
– volume: 18
  start-page: 367
  issue: 4
  year: 2018
  end-page: 374
  article-title: Simple, reliable, and time‐efficient colorimetric method for the assessment of mitochondrial function and toxicity
  publication-title: Bosn J Basic Med Sci
– volume: 29
  start-page: 368
  issue: 5
  year: 2019
  end-page: 377
  article-title: A review on potential toxicity of dental material and screening their biocompatibility
  publication-title: Toxicol Mech Methods
– volume: 22
  start-page: 703
  issue: 4
  year: 2022
  end-page: 712
  article-title: Different methods for cell viability and proliferation assay: essential tools in pharmaceutical studies
  publication-title: Anti Cancer Agents Med Chem
– volume: 5
  start-page: 331
  issue: 2
  year: 2005
  end-page: 338
  article-title: Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles
  publication-title: Nano Lett
– volume: 1
  start-page: 454
  issue: 7
  year: 1999
  end-page: 456
  article-title: Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey
  publication-title: Nature Cell Biol
– volume: 23
  start-page: 1505
  issue: 5
  year: 2018
  end-page: 1513
  article-title: A simplified colorimetric method for rapid detection of cell viability and toxicity in adherent cell culture systems
  publication-title: J BUON
– volume: 45
  start-page: 1469
  issue: 5
  year: 2018
  end-page: 1478
  article-title: An overview of apoptosis assays detecting DNA fragmentation
  publication-title: Mol Biol Rep
– volume: 17
  start-page: 1213
  issue: 14
  year: 2016
  end-page: 1221
  article-title: Cell proliferation and cytotoxicity assays
  publication-title: Curr Pharm Biotechnol
– volume: 136
  start-page: 130
  issue: 1
  year: 1993
  end-page: 136
  article-title: Radiation‐induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay
  publication-title: Radiat Res
– year: 2004
– volume: 148
  start-page: 2207
  issue: 7
  year: 1992
  end-page: 2216
  article-title: Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
  publication-title: J Immunol
– start-page: Ch. 1
  year: 2023
– volume: 26
  start-page: 497
  issue: 6
  year: 2014
  end-page: 511
  article-title: Cell death and autophagy in tuberculosis
  publication-title: Sem Immunol
– volume: 3
  year: 2017
  article-title: A quantitative real‐time approach for discriminating apoptosis and necrosis
  publication-title: Cell Death Discov
– volume: 139
  start-page: 143
  issue: 1
  year: 2007
  end-page: 156
  article-title: Screening and detection of apoptosis
  publication-title: J Surg Res
– volume: 89
  start-page: 216
  issue: 3
  year: 2012
  end-page: 221
  article-title: A comparison of TO‐PRO‐1 iodide and 5‐CFDA‐AM staining methods for assessing viability of planktonic algae with epifluorescence microscopy
  publication-title: J Microbiol Meth
– volume: 27
  start-page: 482
  issue: 7‐8
  year: 2022
  end-page: 508
  article-title: Programmed cell death detection methods: a systematic review and a categorical comparison
  publication-title: Apoptosis
– volume: 65
  start-page: 55
  issue: 1‐2
  year: 1983
  end-page: 63
  article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
  publication-title: J Immunol Methods
– volume: 156
  start-page: 1307
  issue: 4
  year: 2000
  end-page: 1316
  article-title: Increased phosphorylated extracellular Signal‐Regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice
  publication-title: Am J Pathol
– volume: 48
  start-page: 325
  issue: 4
  year: 2010
  end-page: 327
  article-title: Automated handheld instrument improves counting precision across multiple cell lines
  publication-title: Future Sci
– volume: 16
  start-page: 69
  issue: 1
  year: 1977
  end-page: 88
  article-title: Trypan blue: identification and teratogenic and oncogenic activities of its coloured constituents
  publication-title: Chem Biol Interact
– volume: 32
  start-page: 345
  issue: 6
  year: 2003
  end-page: 369
  article-title: Apoptosis: programmed cell death at a molecular level
  publication-title: Semin Arthritis Rheum
– volume: 11
  start-page: 127
  year: 2005
  end-page: 152
– volume: 175
  start-page: 184
  issue: 1
  year: 1988
  end-page: 191
  article-title: A simple technique for quantitation of low levels of DNA damage in individual cells
  publication-title: Exp Cell Res
– volume: 64
  start-page: 316
  issue: 1
  year: 2004
  end-page: 321
  article-title: Enhanced radiation‐induced cell killing and prolongation of γH2AX foci expression by the histone deacetylase inhibitor MS‐275
  publication-title: Cancer Res
– volume: 120
  start-page: 159
  issue: 3
  year: 2018
  end-page: 167
  article-title: Tetrazolium salts and formazan products in cell biology: viability assessment, fluorescence imaging, and labeling perspectives
  publication-title: Acta Histochem
– volume: 3
  start-page: 161
  issue: 2
  year: 2009
  end-page: 171
  article-title: CeO2 nanoparticles induce DNA damage towards human dermal fibroblasts
  publication-title: Nanotoxicology
– volume: 294
  start-page: 934
  issue: 5
  year: 2002
  end-page: 939
  article-title: Necrosis has orderly DNA fragmentations
  publication-title: Biochem Biophys Res Commun
– volume: 4
  issue: 7
  year: 2010
  article-title: Development and validation of a quantitative, high‐throughput, fluorescent‐based bioassay to detect schistosoma viability
  publication-title: PLoS Neglected Trop Dis
– volume: 77
  start-page: 383
  year: 1963
  end-page: 393
  article-title: Studies on succinate‐tetrazolium reductase systems. iii. points of coupling of four different tetrazolium salts
  publication-title: Biochem Biophys Acta
– volume: 5
  issue: 1
  year: 2015
  article-title: Light‐induced cell damage in live‐cell super‐resolution microscopy
  publication-title: Sci Rep
– volume: 20
  start-page: 131
  issue: 2
  year: 2013
  end-page: 139
  article-title: Apoptosis and necrosis of human breast cancer cells by an aqueous extract of garden cress ( ) seeds
  publication-title: Saudi J Biol Sci
– volume: 55
  start-page: 259
  issue: 3
  year: 2020
  end-page: 271
  article-title: Cellular mechanisms and regulation of quiescence
  publication-title: Dev Cell
– volume: 35
  start-page: 495
  issue: 4
  year: 2007
  end-page: 516
  article-title: Apoptosis: a review of programmed cell death
  publication-title: Toxicol Pathol
– volume: 14
  start-page: 5461
  issue: 9
  year: 2013
  end-page: 5465
  article-title: Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
  publication-title: Asian Pac J Cancer Prev
– volume: 19
  start-page: 1518
  issue: 11
  year: 1996
  end-page: 1520
  article-title: A combined assay of cell viability and in vitro cytotoxicity with a highly water‐soluble tetrazolium salt, neutral red and crystal violet
  publication-title: Biol Pharm Bull
– start-page: 45
  year: 2011
  end-page: 56
– volume: 53
  start-page: 198
  issue: 1
  year: 2007
  end-page: 214
  article-title: BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation
  publication-title: Brain Res Rev
– year: 2004
  article-title: Cell Viability Assays
– volume: 14
  start-page: 935
  issue: 12
  year: 1995
  end-page: 944
  article-title: Assessing cellular proliferation: what's worth measuring?
  publication-title: Hum Exp Toxicol
– volume: 11
  start-page: 3269
  issue: 6
  year: 2012
  end-page: 3280
  article-title: Changes in mitochondrial proteome of renal tubular cells induced by calcium oxalate monohydrate crystal adhesion and internalization are related to mitochondrial dysfunction
  publication-title: J Proteome Res
– volume: 4
  start-page: 183
  issue: 2
  year: 1999
  end-page: 191
  article-title: Adhesion‐mediated signaling in the regulation of mammary epithelial cell survival
  publication-title: J Mammary Gland Biol Neoplasia
– volume: 5
  start-page: 56
  issue: 1
  year: 1953
  end-page: 69
  article-title: Studies on the mechanism of Janus Green B staining of mitochondria
  publication-title: Exp Cell Res
– volume: 315
  year: 2020
  article-title: Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity
  publication-title: Chem Biol Interact
– volume: 278
  start-page: 5639
  issue: 8
  year: 2003
  end-page: 5645
  article-title: BCL‐2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA*
  publication-title: J Biol Chem
– volume: 336
  start-page: 69
  issue: 1
  year: 1995
  end-page: 77
  article-title: The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
  publication-title: Mutat Res
– volume: 19
  start-page: 398
  issue: 4
  year: 2021
  end-page: 414
  article-title: Methods for monitoring cancer cell pyroptosis
  publication-title: Cancer Biol Med
– volume: 170
  start-page: 1
  issue: 1
  year: 1993
  end-page: 8
  article-title: In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
  publication-title: J Pathol
– volume: 446
  start-page: 351
  year: 2008
  end-page: 367
– volume: 1866
  start-page: 300
  issue: 2
  year: 2016
  end-page: 319
  article-title: Guidelines for the selection of functional assays to evaluate the hallmarks of cancer
  publication-title: Biochim Biophys Acta
– volume: 12
  start-page: 251
  issue: 3
  year: 1998
  end-page: 258
  article-title: Simultaneous evaluation of cell viability by neutral red, MTT and crystal violet staining assays of the same cells
  publication-title: Toxicol In Vitro
– volume: 15
  start-page: 482
  issue: 3
  year: 2004
  end-page: 490
  article-title: Cellular trajectories of peptide‐modified gold particle complexes:  comparison of nuclear localization signals and peptide transduction domains
  publication-title: Bioconjug Chem
– volume: 12
  start-page: 1569
  issue: 6
  year: 2001
  end-page: 1582
  article-title: Involvement of p38 in apoptosis‐associated membrane blebbing and nuclear condensation
  publication-title: Mol Biol Cell
– volume: 14
  start-page: 1068
  issue: 7
  year: 2014
  end-page: 1079
  article-title: Comparison of methods used for assessing the viability and vitality of yeast cells
  publication-title: FEMS Yeast Res
– volume: 366
  start-page: 197
  issue: 2
  year: 2007
  end-page: 206
  article-title: A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers
  publication-title: Anal Biochem
– volume: 6
  issue: 12
  year: 2011
  article-title: A novel multiplex cell viability assay for high‐throughput RNAi screening
  publication-title: PLoS One
– start-page: 41
  year: 2012
  end-page: 47
– volume: 8
  start-page: 3069
  issue: 9
  year: 2008
  end-page: 3074
  article-title: Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity
  publication-title: Nano Lett
– volume: 82
  start-page: 1107
  issue: 13
  year: 1990
  end-page: 1112
  article-title: New colorimetric cytotoxicity assay for anticancer‐drug screening
  publication-title: J Natl Cancer Inst
– volume: 14
  year: 2023
  article-title: The detection of DNA damage response in MCF7 and MDA‐MB‐231 breast cancer cell lines after x‐ray exposure
  publication-title: Genome Integr
– volume: 478
  start-page: 89
  issue: 1‐2
  year: 2001
  end-page: 96
  article-title: Comet assay and early apoptosis
  publication-title: Mutat Res
– volume: 97
  start-page: 24
  year: 2018
  end-page: 32
  article-title: A comparison of cytotoxicity assays in medical device regulatory studies
  publication-title: RTP
– volume: 42
  start-page: 320
  issue: 10
  year: 2006
  end-page: 323
  article-title: Differences in estimates of cisplatin‐induced cell kill between colorimetric and cell count/colony assays
  publication-title: In Vitro Cell Dev Biol Anim
– volume: 41
  start-page: 506
  issue: 1
  year: 2003
  end-page: 508
  article-title: Uses and limitations of the XTT assay in studies of candida growth and metabolism
  publication-title: J Clin Microbiol
– volume: 29
  start-page: 191
  issue: 3
  year: 1997
  end-page: 196
  article-title: Laser scanning cytometry distinguishes lymphocytes, monocytes, and granulocytes by differences in their chromatin structure
  publication-title: Cytometry
– volume: 24
  start-page: 1121
  issue: 7
  year: 2003
  end-page: 1131
  article-title: cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
  publication-title: Biomaterials
– volume: 52
  start-page: 338
  issue: 2‐3
  year: 1968
  end-page: 348
  article-title: Deposition of Janus green B and pinocyanol in mitochondria of supravitally stained KB cells
  publication-title: Exp Cell Res
– volume: 66
  start-page: 1
  year: 2001
  end-page: 27
– volume: 22
  start-page: 1304
  issue: 5
  year: 2007
  end-page: 1309
  article-title: The use of alamar blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells
  publication-title: Hum Reprod
– volume: 9
  issue: 3
  year: 2014
  article-title: Epigenetic silencing of apoptosis‐inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells
  publication-title: PLoS One
– volume: 358
  start-page: 81
  issue: 1
  year: 2010
  end-page: 92
  article-title: Conventional apoptosis assays using propidium iodide generate a significant number of false positives that prevent accurate assessment of cell death
  publication-title: J Immunol Methods
– start-page: 7
  year: 2011
  end-page: 12
– volume: 47
  start-page: 936
  issue: 4
  year: 1987
  end-page: 942
  article-title: Evaluation of a tetrazolium‐based semiautomated colorimetric assay: assessment of chemosensitivity testing
  publication-title: Cancer Res
– volume: 70
  start-page: 222
  year: 2005
  end-page: 230
  article-title: Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
  publication-title: Biochemistry. Biokhimiia
– volume: 329
  start-page: 35
  issue: 1
  year: 2004
  end-page: 42
  article-title: Use of cellular glucose‐6‐phosphate dehydrogenase for cell quantitation: applications in cytotoxicity and apoptosis assays
  publication-title: Anal Biochem
– start-page: 219
  year: 2011
  end-page: 236
– volume: 65
  start-page: 1161
  issue: 11
  year: 2003
  end-page: 1166
  article-title: Detection of radiation‐induced apoptosis using the comet assay
  publication-title: J Vet Med Sci
– volume: 15
  issue: 2
  year: 2023
  article-title: Experimental methods for the biological evaluation of nanoparticle‐based drug delivery risks
  publication-title: Pharmaceutics
– volume: 18
  start-page: 1663
  issue: 8
  year: 2020
  end-page: 1672
  article-title: Diarrhea during COVID‐19 infection: pathogenesis, epidemiology, prevention, and management
  publication-title: Clin Gastroenterol Hepatol
– volume: 3
  start-page: 1125
  issue: 7
  year: 2008
  end-page: 1131
  article-title: Neutral red uptake assay for the estimation of cell viability/cytotoxicity
  publication-title: Nat Protoc
– volume: 12
  start-page: 381
  issue: 5
  year: 2017
  end-page: 389
  article-title: Old drug scaffold, new activity: thalidomide‐correlated compounds exert different effects on breast cancer cell growth and progression
  publication-title: ChemMedChem
– volume: 45
  start-page: 2283
  issue: 5
  year: 1985
  end-page: 2287
  article-title: Double labeling of S‐phase murine cells with bromodeoxyuridine and a second DNA‐specific probe
  publication-title: Cancer Res
– volume: 61
  start-page: 117
  issue: 2
  year: 2013
  end-page: 129
  article-title: Determination of apoptotic and necrotic cell death and
  publication-title: Methods
– start-page: 491
  year: 2013
  end-page: 550
– volume: 31
  start-page: 2178
  issue: 8
  year: 2003
  end-page: 2186
  article-title: Ensemble and single‐molecule fluorescence spectroscopic study of the binding modes of the bis‐benzimidazole derivative Hoechst 33258 with DNA
  publication-title: Nucleic Acids Res
– volume: 8
  issue: 1
  year: 2011
  article-title: Problems and challenges in the development and validation of human cell‐based assays to determine nanoparticle‐induced immunomodulatory effects
  publication-title: Part Fibre Toxicol
– volume: 33
  start-page: 853
  issue: 12
  year: 1950
  end-page: 864
  article-title: Resazurin reducing time as an indicator of bovine semen fertilizing capacity
  publication-title: J Dairy Sci
– start-page: 17
  year: 1999
  end-page: 23
– volume: 23
  start-page: 255
  year: 2009
  end-page: 262
  article-title: A simple method to measure cell viability in proliferation and cytotoxicity assays
  publication-title: Braz Oral Res
– volume: 84
  start-page: 1415
  issue: 5
  year: 1994
  end-page: 1420
  article-title: Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
  publication-title: Blood
– volume: 3
  start-page: 207
  issue: 7
  year: 1991
  end-page: 212
  article-title: Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
  publication-title: Cancer Commun
– year: 2017
  article-title: In vitro cytotoxicity and cell viability assays: principles
– volume: 2
  start-page: 685
  issue: 6
  year: 1964
  end-page: 694
  article-title: Evaluation of the trypan blue technique for determination of cell viability
  publication-title: Transplantation
– volume: 8
  start-page: 1131
  issue: 6
  year: 2001
  end-page: 1135
  article-title: Calcein‐Acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants
  publication-title: Clin Diagn Lab Immunol
– volume: 52
  start-page: 252
  issue: 6
  year: 1998
  end-page: 258
  article-title: Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity
  publication-title: Biomed Pharmacother
– volume: 33
  start-page: 6
  issue: 1
  year: 2022
  end-page: 10
  article-title: Key considerations when using the sulforhodamine B assay for screening novel anticancer agents
  publication-title: Anticancer Drugs
– start-page: 151
  year: 2008a
  end-page: 162
– start-page: 335
  year: 2014
  end-page: 361
– volume: 7
  start-page: 9
  year: 2015
  end-page: 16
  article-title: Validation of three viable‐cell counting methods: manual, semi‐automated, and automated
  publication-title: Biotechnol Rep
– volume: 98
  start-page: 188
  issue: 1
  year: 1958
  end-page: 192
  article-title: Determination of cell viability
  publication-title: Proc Soc Exp Biol Med
– volume: 31
  start-page: 1
  issue: 1
  year: 1998
  end-page: 9
  article-title: Annexin V‐affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure
  publication-title: Cytometry
– volume: 16
  start-page: 4963
  issue: 11
  year: 2021
  end-page: 4991
  article-title: Analysis of clonogenic growth
  publication-title: Nat Protoc
– volume: 62
  start-page: 421
  issue: 2
  year: 1970
  end-page: 432
  article-title: Terminal lens cell differentiation
  publication-title: Exp Cell Res
– volume: 154
  start-page: 47
  year: 2018
  end-page: 55
  article-title: Biochemical and biophysical characterization of water‐soluble pectin from Opuntia ficus‐indica and its potential cytotoxic activity
  publication-title: Phytochemistry
– volume: 17
  start-page: 534
  issue: 3
  year: 2010
  end-page: 539
  article-title: The cleaved‐caspase‐3 antibody is a marker of caspase‐9‐like DRONC activity in Drosophila
  publication-title: Cell Death Differ
– volume: 159
  start-page: 109
  issue: 1
  year: 1986
  end-page: 113
  article-title: Determination of cell number in monolayer cultures
  publication-title: Anal Biochem
– volume: 29
  start-page: 1573
  issue: 11
  year: 1993
  end-page: 1577
  article-title: Genistein inhibits tumour cell growth but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival
  publication-title: Eur J Cancer
– volume: 185
  start-page: 377
  issue: 2
  year: 1990
  end-page: 382
  article-title: An enzyme‐linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures
  publication-title: Anal Biochem
– volume: 545
  start-page: 1
  year: 2014
  end-page: 33
– volume: 267
  start-page: 5421
  issue: 17
  year: 2000
  end-page: 5426
  article-title: Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
  publication-title: Eur J Biochem
– volume: 160
  start-page: 81
  issue: 1
  year: 1993
  end-page: 88
  article-title: The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
  publication-title: J Immunol Methods
– volume: 24
  start-page: 439
  issue: 5
  year: 2009
  end-page: 445
  article-title: Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an study in Balb/3T3 mouse fibroblasts
  publication-title: Mutagenesis
– volume: 1867
  issue: 10
  year: 2020
  article-title: Kinetic and protective role of autophagy in manganese‐exposed BV‐2 cells
  publication-title: Biochim Biophys Acta Mol Cell Res
– volume: 21
  start-page: 35
  issue: 1
  year: 2005
  end-page: 56
  article-title: Mechanisms of apoptosis through structural biology
  publication-title: Annu Rev Cell Dev Biol
– volume: 17
  start-page: 841
  year: 2013
  end-page: 850
  article-title: Comparison of different live/dead stainings for detection and quantification of adherent microorganisms in the initial oral biofilm
  publication-title: Clin Oral Investig
– volume: 68
  start-page: 5728
  issue: 11
  year: 2002
  end-page: 5736
  article-title: Identification of DNA‐synthesizing bacterial cells in coastal North Sea plankton
  publication-title: Appl Environ Microbiol
– volume: 50
  start-page: 141
  issue: 1
  year: 2006
  end-page: 147
  article-title: Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines
  publication-title: Eur Urol
– volume: 27
  start-page: 47
  issue: 1
  year: 2003
  end-page: 54
  article-title: The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours
  publication-title: Cancer Detect Prev
– volume: 112
  start-page: 155
  year: 1999
  end-page: 161
  article-title: Early detection of staurosporine‐induced apoptosis by comet and annexin V assays
  publication-title: Histochem Cell Biol
– volume: 37
  start-page: 197
  issue: 3
  year: 1999
  end-page: 204
  article-title: Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity
  publication-title: Cytometry
– volume: 48
  start-page: 4827
  issue: 17
  year: 1988
  end-page: 4833
  article-title: Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
  publication-title: Cancer Res
– volume: 15
  start-page: 34
  issue: 1
  year: 2016
  article-title: Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells
  publication-title: Mol Cancer
– volume: 2
  start-page: 1412
  issue: 12
  year: 2006
  end-page: 1417
  article-title: Evaluation of quantum dot cytotoxicity based on intracellular uptake
  publication-title: Small
– volume: 25
  start-page: 500
  issue: 3
  year: 2009
  end-page: 504
  article-title: Effect of fetal calf serum on cellular proliferation of mouse Y1 adrenocortical cells
  publication-title: Pak J Med Sci
– volume: 60
  start-page: 619
  issue: 1
  year: 1998
  end-page: 642
  article-title: The mitochondrial death/life regulator in apoptosis and necrosis
  publication-title: Annu Rev Physiol
– volume: 18
  start-page: 3054
  issue: 13
  year: 2020
  end-page: 3055
  article-title: Putative mechanisms of diarrhea in COVID‐19
  publication-title: Clin Gastroenterol Hepatol
– volume: 9
  year: 2021
– volume: 58
  start-page: 45
  issue: 1
  year: 2004
  end-page: 52
  article-title: A short history of the initial application of anti–5‐BrdU to the detection and measurement of S phase
  publication-title: Cytometry, Part A
– volume: 43
  start-page: 258
  issue: 1
  year: 1983
  end-page: 264
  article-title: Comparison of dye exclusion assays with a clonogenic assay in the determination of drug‐induced cytotoxicity
  publication-title: Cancer Res
– volume: 94
  start-page: 57
  issue: 1
  year: 1986
  end-page: 63
  article-title: Use of MTT colorimetric assay to measure cell activation
  publication-title: J Immunol Methods
– volume: 21
  start-page: A.3B.1
  issue: 1
  year: 1997
  end-page: A.3B.2
  article-title: Trypan blue exclusion test of cell viability
  publication-title: Curr Protoc Immunol
– volume: 492
  start-page: 8
  year: 2016
  end-page: 12
  article-title: Application of a non‐hazardous vital dye for cell counting with automated cell counters
  publication-title: Anal Biochem
– start-page: Ch. 1
  year: 2017
– volume: 10
  year: 2020
  article-title: Phagocytosis of necrotic debris at sites of injury and inflammation
  publication-title: Front Immunol
– volume: 5
  start-page: 33
  issue: 2
  year: 2017
  end-page: 34
  article-title: An overview of the most common methods for assessing cell viability
  publication-title: J Res Med Dent
– volume: 38
  start-page: 179
  issue: 2
  year: 2001
  end-page: 193
  article-title: Flow cytometry in analysis of cell cycle and apoptosis
  publication-title: Sem Hematol
– volume: 23
  start-page: 1505
  year: 2018
  end-page: 1513
  article-title: A simplified colorimetric method for rapid detection of cell viability and toxicity in adherent cell culture systems
  publication-title: J BUON
– volume: 182
  start-page: 265
  issue: 5
  year: 1987
  end-page: 274
  article-title: Incidence of chromosome aberrations in mammalian sperm stained with Hoechst 33342 and UV‐laser irradiated during flow sorting
  publication-title: Mutat Res
– volume: 5
  start-page: 181
  issue: 1
  year: 2012
  end-page: 205
  article-title: Assessing nanoparticle toxicity
  publication-title: Annu Rev Anal Chem
– volume: 5
  start-page: 25
  issue: 1
  year: 2015
  end-page: 28
  article-title: An update to DNA ladder assay for apoptosis detection
  publication-title: Bioimpacts
– volume: 16
  start-page: 283
  issue: 2
  year: 2000
  end-page: 288
  article-title: Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide
  publication-title: Int J Oncol
– volume: 17
  start-page: 2
  issue: 1
  year: 2020
  end-page: 22
  article-title: Do we have a satisfactory cell viability assay? Review of the currently commercially‐available assays
  publication-title: Curr Drug Discovery Technol
– volume: 8
  start-page: 43
  issue: 2
  year: 2022
  article-title: Histological stains and their application in teaching and research
  publication-title: Asian J Health Sci
– volume: 274
  start-page: 77
  issue: 1
  year: 2003
  end-page: 82
  article-title: Chemiluminescence‐based BrdU ELISA to measure DNA synthesis
  publication-title: J Immunol Methods
– ident: e_1_2_9_41_1
  doi: 10.1146/annurev.physiol.60.1.619
– start-page: 351
  volume-title: Methods in Enzymology
  year: 2008
  ident: e_1_2_9_30_1
– ident: e_1_2_9_182_1
  doi: 10.1099/jmm.0.46915-0
– ident: e_1_2_9_181_1
  doi: 10.21769/BioProtoc.1984
– ident: e_1_2_9_138_1
  doi: 10.1007/978-1-4614-8220-8_18
– ident: e_1_2_9_5_1
  doi: 10.3390/pharmaceutics15020612
– ident: e_1_2_9_85_1
  doi: 10.1146/annurev-anchem-062011-143134
– ident: e_1_2_9_81_1
  doi: 10.1016/j.devcel.2020.09.029
– ident: e_1_2_9_28_1
  doi: 10.2174/1570163815666180925095433
– ident: e_1_2_9_63_1
  doi: 10.3727/095535491820873191
– ident: e_1_2_9_127_1
  doi: 10.1016/j.cbi.2019.108868
– ident: e_1_2_9_24_1
  doi: 10.1007/BF02618887
– ident: e_1_2_9_46_1
  doi: 10.3168/jds.S0022-0302(50)91981-3
– ident: e_1_2_9_104_1
  doi: 10.2131/jts.42.569
– ident: e_1_2_9_173_1
  doi: 10.1038/nrd3373
– ident: e_1_2_9_112_1
  doi: 10.1002/cyto.a.20012
– start-page: Ch. 1
  volume-title: Genotoxicity
  year: 2017
  ident: e_1_2_9_188_1
– ident: e_1_2_9_130_1
  doi: 10.1016/0165-1161(87)90011-2
– ident: e_1_2_9_171_1
  doi: 10.1016/S0037-1963(01)90051-4
– ident: e_1_2_9_153_1
  doi: 10.1292/jvms.65.1161
– ident: e_1_2_9_157_1
  doi: 10.1080/17435390902788086
– ident: e_1_2_9_120_1
  doi: 10.1016/j.eururo.2005.12.043
– ident: e_1_2_9_16_1
  doi: 10.1016/j.ab.2004.02.007
– ident: e_1_2_9_91_1
  doi: 10.1002/cbdv.202201098
– ident: e_1_2_9_107_1
  doi: 10.17305/bjbms.2018.3323
– ident: e_1_2_9_23_1
  doi: 10.1016/j.phytochem.2018.06.015
– ident: e_1_2_9_106_1
  doi: 10.1074/jbc.M203080200
– volume: 23
  start-page: 1505
  issue: 5
  year: 2018
  ident: e_1_2_9_111_1
  article-title: A simplified colorimetric method for rapid detection of cell viability and toxicity in adherent cell culture systems
  publication-title: J BUON
– ident: e_1_2_9_195_1
  doi: 10.7314/APJCP.2013.14.9.5461
– ident: e_1_2_9_55_1
  doi: 10.1016/0006-3002(63)90513-4
– ident: e_1_2_9_89_1
  doi: 10.3181/00379727-98-23985
– ident: e_1_2_9_79_1
  doi: 10.1021/bc034189q
– ident: e_1_2_9_129_1
  doi: 10.1101/pdb.prot087205
– ident: e_1_2_9_193_1
  doi: 10.1038/nprot.2006.339
– ident: e_1_2_9_12_1
  doi: 10.1517/17460441.3.6.655
– ident: e_1_2_9_70_1
  doi: 10.1021/nl047996m
– ident: e_1_2_9_50_1
  doi: 10.1046/j.1432-1327.2000.01606.x
– ident: e_1_2_9_126_1
  doi: 10.1021/bi047374f
– ident: e_1_2_9_44_1
  doi: 10.1038/s41596-021-00615-0
– ident: e_1_2_9_11_1
  doi: 10.1248/bpb.19.1518
– ident: e_1_2_9_59_1
  doi: 10.1016/0022-1759(86)90215-2
– ident: e_1_2_9_72_1
  doi: 10.1016/j.mimet.2012.03.005
– ident: e_1_2_9_3_1
  doi: 10.1021/nn800596w
– ident: e_1_2_9_164_1
  doi: 10.1002/cmdc.201600629
– ident: e_1_2_9_22_1
  doi: 10.1097/00007890-196411000-00001
– ident: e_1_2_9_174_1
  doi: 10.1016/S0142-9612(02)00445-3
– ident: e_1_2_9_176_1
  doi: 10.1016/j.ymeth.2013.02.011
– ident: e_1_2_9_21_1
  doi: 10.1021/acs.accounts.9b00289
– ident: e_1_2_9_155_1
  doi: 10.1007/s004180050402
– ident: e_1_2_9_34_1
  doi: 10.1002/cyto.990130802
– ident: e_1_2_9_26_1
  doi: 10.1016/j.yrtph.2018.06.003
– ident: e_1_2_9_154_1
  doi: 10.2307/3578650
– ident: e_1_2_9_177_1
  doi: 10.1093/jnci/82.13.1107
– ident: e_1_2_9_156_1
  doi: 10.1002/(SICI)1097-0320(19991101)37:3<197::AID-CYTO6>3.0.CO;2-L
– ident: e_1_2_9_186_1
  doi: 10.1016/S0003-9861(02)00217-5
– ident: e_1_2_9_128_1
  doi: 10.1016/S0014-4827(85)80052-5
– ident: e_1_2_9_179_1
  doi: 10.1385/1-59259-869-2:039
– ident: e_1_2_9_18_1
  doi: 10.1007/978-1-61779-080-5_19
– ident: e_1_2_9_144_1
  doi: 10.1053/sarh.2003.50005
– ident: e_1_2_9_101_1
  doi: 10.1016/j.bbamcr.2020.118787
– ident: e_1_2_9_183_1
  doi: 10.1016/0003-2697(86)90314-3
– volume: 48
  start-page: 325
  issue: 4
  year: 2010
  ident: e_1_2_9_96_1
  article-title: Automated handheld instrument improves counting precision across multiple cell lines
  publication-title: Future Sci
– ident: e_1_2_9_159_1
  doi: 10.1021/nl801661w
– ident: e_1_2_9_92_1
  doi: 10.15419/ajhs.v8i2.514
– ident: e_1_2_9_147_1
  doi: 10.1016/j.sjbs.2012.12.002
– ident: e_1_2_9_75_1
  doi: 10.1016/B978-012529650-2/50047-0
– ident: e_1_2_9_84_1
  doi: 10.3390/ijms222312827
– ident: e_1_2_9_119_1
  doi: 10.1016/S0022-1759(02)00437-4
– ident: e_1_2_9_114_1
  doi: 10.1096/fj.02-0142fje
– start-page: 1
  volume-title: Methods in Cell Biology
  year: 2001
  ident: e_1_2_9_139_1
– ident: e_1_2_9_36_1
  doi: 10.1385/MB:26:3:249
– ident: e_1_2_9_113_1
  doi: 10.1016/S0002-9440(10)65001-8
– ident: e_1_2_9_175_1
  doi: 10.3389/fimmu.2019.03030
– ident: e_1_2_9_131_1
  doi: 10.1038/srep15348
– ident: e_1_2_9_137_1
  doi: 10.1146/annurev.cellbio.21.012704.131040
– ident: e_1_2_9_150_1
  doi: 10.1016/j.ymeth.2009.02.016
– ident: e_1_2_9_94_1
  doi: 10.1016/j.ab.2015.09.010
– ident: e_1_2_9_143_1
  doi: 10.1038/cdd.2009.185
– ident: e_1_2_9_163_1
  doi: 10.1016/0014-4827(70)90573-2
– ident: e_1_2_9_184_1
– ident: e_1_2_9_110_1
  doi: 10.1021/pr300018c
– ident: e_1_2_9_122_1
  doi: 10.1016/j.smim.2014.10.001
– ident: e_1_2_9_39_1
  doi: 10.20892/j.issn.2095-3941.2021.0504
– ident: e_1_2_9_124_1
  doi: 10.3390/chemosensors6020018
– ident: e_1_2_9_97_1
  doi: 10.1016/0009-2797(77)90154-5
– ident: e_1_2_9_17_1
  doi: 10.1590/S1806-83242009000300006
– ident: e_1_2_9_145_1
  doi: 10.15171/bi.2015.01
– ident: e_1_2_9_187_1
  doi: 10.1007/978-1-61779-108-6_12
– volume: 23
  start-page: 1505
  year: 2018
  ident: e_1_2_9_25_1
  article-title: A simplified colorimetric method for rapid detection of cell viability and toxicity in adherent cell culture systems
  publication-title: J BUON
– volume: 2
  start-page: 295
  issue: 3
  year: 2003
  ident: e_1_2_9_161_1
  article-title: Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine
  publication-title: Genet Mol Res
– ident: e_1_2_9_141_1
  doi: 10.1371/journal.pone.0091558
– ident: e_1_2_9_198_1
  doi: 10.1091/mbc.12.6.1569
– ident: e_1_2_9_146_1
  doi: 10.1002/path.1711700102
– ident: e_1_2_9_49_1
  doi: 10.1016/j.cgh.2020.06.008
– volume: 40
  start-page: 228
  issue: 2
  year: 2022
  ident: e_1_2_9_93_1
  article-title: Sperm vitality and necrozoospermia: diagnosis, management, and results of a global survey of clinical practice
  publication-title: WJMH
– ident: e_1_2_9_196_1
  doi: 10.1016/j.bbcan.2016.10.002
– ident: e_1_2_9_140_1
– ident: e_1_2_9_67_1
  doi: 10.1128/CDLI.8.6.1131-1135.2001
– ident: e_1_2_9_71_1
  doi: 10.5455/jrmds.2017526
– ident: e_1_2_9_123_1
  doi: 10.1371/journal.pone.0028338
– ident: e_1_2_9_133_1
  doi: 10.4049/jimmunol.148.7.2207
– ident: e_1_2_9_125_1
  doi: 10.1093/nar/gkg308
– volume: 54
  start-page: 10
  year: 2011
  ident: e_1_2_9_47_1
  article-title: An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells
  publication-title: Proc West Pharmacol Soc
– ident: e_1_2_9_61_1
  doi: 10.1002/fft2.44
– ident: e_1_2_9_189_1
  doi: 10.2174/1871520621999201230202614
– ident: e_1_2_9_185_1
  doi: 10.1007/978-3-7091-0885-7_15
– ident: e_1_2_9_135_1
  doi: 10.1038/15690
– ident: e_1_2_9_103_1
  doi: 10.1016/S0887-2333(97)00107-0
– ident: e_1_2_9_160_1
  doi: 10.1016/S1383-5718(02)00251-6
– ident: e_1_2_9_31_1
  doi: 10.1007/978-1-59745-339-4_12
– ident: e_1_2_9_20_1
  doi: 10.1002/cptx.21
– ident: e_1_2_9_38_1
  doi: 10.1161/01.CIR.99.21.2757
– ident: e_1_2_9_19_1
  doi: 10.1038/s41598-021-97894-0
– volume: 47
  start-page: 936
  issue: 4
  year: 1987
  ident: e_1_2_9_53_1
  article-title: Evaluation of a tetrazolium‐based semiautomated colorimetric assay: assessment of chemosensitivity testing
  publication-title: Cancer Res
– volume: 16
  start-page: 283
  issue: 2
  year: 2000
  ident: e_1_2_9_168_1
  article-title: Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide
  publication-title: Int J Oncol
– ident: e_1_2_9_149_1
  doi: 10.1016/0921-8777(94)00043-6
– ident: e_1_2_9_151_1
  doi: 10.1016/j.etap.2007.03.001
– ident: e_1_2_9_165_1
  doi: 10.1177/002215549904700614
– volume: 25
  start-page: 500
  issue: 3
  year: 2009
  ident: e_1_2_9_45_1
  article-title: Effect of fetal calf serum on cellular proliferation of mouse Y1 adrenocortical cells in vitro
  publication-title: Pak J Med Sci
– ident: e_1_2_9_65_1
  doi: 10.1089/adt.2005.3.675
– ident: e_1_2_9_190_1
  doi: 10.1371/journal.pone.0126313
– ident: e_1_2_9_199_1
  doi: 10.1385/1-59259-687-8:17
– ident: e_1_2_9_109_1
  doi: 10.1016/0014-4827(53)90094-9
– ident: e_1_2_9_178_1
  doi: 10.1007/978-1-61779-108-6_7
– ident: e_1_2_9_27_1
  doi: 10.1177/096032719501401201
– ident: e_1_2_9_87_1
  doi: 10.1002/0471142735.ima03bs21
– ident: e_1_2_9_7_1
  doi: 10.5772/intechopen.71923
– ident: e_1_2_9_54_1
  doi: 10.1016/j.acthis.2018.02.005
– volume: 48
  start-page: 4827
  issue: 17
  year: 1988
  ident: e_1_2_9_2_1
  article-title: Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
  publication-title: Cancer Res
– ident: e_1_2_9_100_1
  doi: 10.1007/BF01962793
– ident: e_1_2_9_180_1
  doi: 10.1038/nprot.2006.179
– start-page: 1
  volume-title: Methods in Enzymology
  year: 2014
  ident: e_1_2_9_40_1
– ident: e_1_2_9_69_1
  doi: 10.1002/smll.200600218
– ident: e_1_2_9_162_1
  doi: 10.1016/S0753-3322(98)80010-3
– ident: e_1_2_9_166_1
  doi: 10.1007/978-1-61779-860-3_5
– ident: e_1_2_9_74_1
  doi: 10.1007/s00784-012-0792-3
– ident: e_1_2_9_43_1
  doi: 10.1097/CAD.0000000000001131
– ident: e_1_2_9_197_1
  doi: 10.1158/0008-5472.CAN-03-2630
– ident: e_1_2_9_48_1
  doi: 10.1093/humrep/dem011
– volume: 45
  start-page: 2283
  issue: 5
  year: 1985
  ident: e_1_2_9_117_1
  article-title: Double labeling of S‐phase murine cells with bromodeoxyuridine and a second DNA‐specific probe
  publication-title: Cancer Res
– ident: e_1_2_9_29_1
  doi: 10.1038/cdd.2009.44
– ident: e_1_2_9_68_1
  doi: 10.1016/j.cgh.2020.04.001
– volume: 42
  start-page: 320
  issue: 10
  year: 2006
  ident: e_1_2_9_60_1
  article-title: Differences in estimates of cisplatin‐induced cell kill in vitro between colorimetric and cell count/colony assays
  publication-title: In Vitro Cell Dev Biol Anim
– ident: e_1_2_9_88_1
  doi: 10.1007/978-1-61779-108-6_2
– ident: e_1_2_9_132_1
  doi: 10.1182/blood.V84.5.1415.bloodjournal8451415
– ident: e_1_2_9_116_1
  doi: 10.1128/AEM.68.11.5728-5736.2002
– ident: e_1_2_9_33_1
  doi: 10.1016/S0006-291X(02)00587-9
– ident: e_1_2_9_99_1
  doi: 10.1042/CBI20100083
– ident: e_1_2_9_4_1
  doi: 10.1042/bj3080591
– ident: e_1_2_9_10_1
  doi: 10.1016/j.ab.2007.04.007
– ident: e_1_2_9_77_1
  doi: 10.1016/0022-1759(83)90438-6
– ident: e_1_2_9_142_1
  doi: 10.1007/s10495-022-01735-y
– ident: e_1_2_9_158_1
  doi: 10.1093/mutage/gep027
– ident: e_1_2_9_80_1
  doi: 10.1016/j.drup.2010.09.001
– ident: e_1_2_9_83_1
  doi: 10.3389/fcell.2021.645593
– ident: e_1_2_9_136_1
  doi: 10.1002/(SICI)1097-0320(19971101)29:3<191::AID-CYTO1>3.0.CO;2-F
– ident: e_1_2_9_32_1
  doi: 10.1007/s11033-018-4258-9
– ident: e_1_2_9_121_1
  doi: 10.1186/1743-8977-8-8
– ident: e_1_2_9_57_1
  doi: 10.1016/0022-1759(93)90011-U
– ident: e_1_2_9_105_1
  doi: 10.1007/s10541-005-0104-5
– ident: e_1_2_9_51_1
  doi: 10.1016/0959-8049(93)90297-S
– ident: e_1_2_9_134_1
  doi: 10.1002/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R
– ident: e_1_2_9_148_1
  doi: 10.1080/01926230701320337
– ident: e_1_2_9_6_1
  doi: 10.1080/15376516.2019.1566424
– ident: e_1_2_9_13_1
  doi: 10.3329/bjp.v12i2.30892
– ident: e_1_2_9_73_1
  doi: 10.1371/journal.pntd.0000759
– start-page: 127
  volume-title: Biotechnology Annual Review
  year: 2005
  ident: e_1_2_9_52_1
– ident: e_1_2_9_42_1
  doi: 10.2174/1389201017666160808160513
– ident: e_1_2_9_82_1
  doi: 10.1111/1567-1364.12202
– ident: e_1_2_9_192_1
  doi: 10.14293/genint.14.1.001
– ident: e_1_2_9_108_1
  doi: 10.1016/0014-4827(68)90475-8
– start-page: Ch. 1
  volume-title: Cytotoxicity
  year: 2023
  ident: e_1_2_9_8_1
– ident: e_1_2_9_62_1
  doi: 10.1128/JCM.41.1.506-508.2003
– ident: e_1_2_9_14_1
  doi: 10.1385/1-59259-869-2:069
– ident: e_1_2_9_102_1
  doi: 10.1038/nprot.2008.75
– ident: e_1_2_9_170_1
  doi: 10.1016/j.jim.2010.03.019
– ident: e_1_2_9_35_1
  doi: 10.1016/S0027-5107(01)00123-3
– ident: e_1_2_9_172_1
  doi: 10.1038/cddiscovery.2016.101
– ident: e_1_2_9_66_1
  doi: 10.1053/j.gastro.2020.02.055
– ident: e_1_2_9_118_1
  doi: 10.1016/0003-2697(90)90310-6
– start-page: 41
  volume-title: Methods in Enzymology
  year: 2012
  ident: e_1_2_9_86_1
– volume: 2018
  start-page: 465
  issue: 6
  year: 2018
  ident: e_1_2_9_76_1
  article-title: Analysis of cell viability by the lactate dehydrogenase assay
  publication-title: Cold Spring Harb Protoc
– ident: e_1_2_9_98_1
  doi: 10.1007/BF01666038
– ident: e_1_2_9_194_1
  doi: 10.1023/A:1018729308878
– ident: e_1_2_9_78_1
  doi: 10.1016/j.biomaterials.2007.02.034
– ident: e_1_2_9_95_1
  doi: 10.1016/j.btre.2015.04.004
– start-page: Ch. 3
  volume-title: Cytotoxicity
  year: 2022
  ident: e_1_2_9_15_1
– ident: e_1_2_9_9_1
  doi: 10.1186/s12943-016-0517-3
– ident: e_1_2_9_37_1
  doi: 10.1083/jcb.119.3.493
– ident: e_1_2_9_115_1
  doi: 10.1016/j.brainresrev.2006.08.002
– ident: e_1_2_9_167_1
  doi: 10.1016/j.jss.2006.07.034
– ident: e_1_2_9_191_1
  doi: 10.1039/c1pp05014a
– ident: e_1_2_9_64_1
  doi: 10.1016/S0361-090X(02)00171-X
– ident: e_1_2_9_56_1
  doi: 10.1016/0022-1759(83)90303-4
– ident: e_1_2_9_152_1
  doi: 10.1016/0014-4827(88)90265-0
– volume: 43
  start-page: 258
  issue: 1
  year: 1983
  ident: e_1_2_9_90_1
  article-title: Comparison of dye exclusion assays with a clonogenic assay in the determination of drug‐induced cytotoxicity
  publication-title: Cancer Res
– ident: e_1_2_9_169_1
  doi: 10.1016/0022-1759(95)00072-I
– volume: 5
  start-page: 69
  issue: 2
  year: 1995
  ident: e_1_2_9_58_1
  article-title: A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function
  publication-title: Growth Regul
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Snippet Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of...
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SubjectTerms Adenosine
Assaying
Assessments
Biochemistry
Biomolecules
Cell adhesion
Cell death
Cell membranes
Cell survival
Cell viability
Classification
Compartments
Cytotoxicity
cytotoxicity assay
DNA fragmentation
Drug development
Drug screening
Enzymatic activity
Enzyme activity
Evaluation
Membrane permeability
Mortality
Reliability analysis
Toxicity
Title Cell viability and cytotoxicity assays: Biochemical elements and cellular compartments
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbf.4007
https://www.ncbi.nlm.nih.gov/pubmed/38593323
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Volume 42
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