A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

• Published in: Cell biochemistry and function Vol. 39; no. 2; pp. 190 - 217
• Main Authors: Gunata, Mehmet, Parlakpinar, Hakan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2021
• Subjects: acute myocardial infarction; Angioplasty; Antioxidants; Biomarkers; Blood flow; Cardiomyocytes; Cardiovascular diseases; Cardiovascular system; Coronary artery disease; Damage; Drug therapy; experimental models; Fibroblasts; Genetics; Health services; Heart diseases; Heart surgery; Immune system; Injuries; ischaemia/reperfusion injury; Ischemia; Leukocytes; Leukocytes (polymorphonuclear); Morbidity; Muscles; oxidative stress; Pathophysiology; pharmacological treatment; Pharmacology; Platelets; Reperfusion; Smooth muscle; Thrombolysis; ischaemia/reperfusion injury; pharmacological treatment; experimental models; acute myocardial infarction; oxidative stress

Cardiovascular diseases are known to be the most fatal diseases worldwide. Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common cardiovascular diseases. According to the World Health Organization estimates, ischaemic heart disease is the leading global cause of dea...