Population pharmacokinetics of a triple‐secured fibrinogen concentrate administered to afibrinogenaemic patients: Observed age‐ and body weight‐related differences and consequences for dose adjustment in children

• Published in: British journal of clinical pharmacology Vol. 86; no. 2; pp. 329 - 337
• Main Authors: Bellon, Anne, Fuseau, Eliane, Roumanie, Olivier, Lamazure, Jennifer, Stevens, Wil, Dahmane, Amel, Barthez‐Toullec, Malika, Golly, Dominique, Henriet, Céline, Bridey, Françoise
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.02.2020
• Subjects: coagulation, congenital disorders, NONMEM, paediatrics, population analysis; Original; coagulation, congenital disorders, NONMEM, paediatrics, population analysis

Aims The pharmacokinetics (PK) of a triple‐secured fibrinogen concentrate (FC) was assessed in patients ≥40 kg by noncompartmental analysis over a period of 14 days with multiple blood samples. Limited PK time point assessments in children lead to consideration of using Bayesian estimation for paedi...