Topical ionic contra‐viral therapy comprised of digoxin and furosemide as a potential novel treatment approach for common warts

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 31; no. 12; pp. 2088 - 2090
• Main Authors: Kolk, T., Dillingh, M.R., Rijneveld, R., Klaassen, E.S., Koning, M.N.C., Kouwenhoven, S.T.P., Genders, R.E., Bouwes Bavinck, J. N., Feiss, G., Rissmann, R., Burggraaf, J.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.12.2017
• Subjects: Administration, Topical; Digoxin - administration & dosage; Drug Combinations; Female; Furosemide - administration & dosage; Humans; Male; Original Artilces and Short Reports; Short Report; Skin Diseases - drug therapy; Sodium Potassium Chloride Symporter Inhibitors - administration & dosage; Warts - drug therapy; Young Adult

Background DNA viruses such as HPV rely on K+ influx for replication. Both digoxin and furosemide inhibit the K+ influx by interacting with cell membrane ion co‐transporters (Na+/K+‐ATPase and Na+‐K+‐2Cl− co‐transporter‐1, respectively). We therefore hypothesized that these two compounds in a topica...