Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

• Published in: IUBMB life Vol. 74; no. 7; pp. 655 - 671
• Main Authors: Moreno, Andrea, Taleb, Victor, Sebastián, María, Anoz‐Carbonell, Ernesto, Martínez‐Júlvez, Marta, Medina, Milagros
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2022
• Subjects: enzyme kinetics; enzyme species‐specific traits; flavin biosynthesis; FMN:adenylyltransferase; kinetics limiting steps; riboflavin kinase

The biosynthesis of the flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), cofactors used by 2% of proteins, occurs through the sequential action of two ubiquitous activities: a riboflavinkinase (RFK) that phosphorylates the riboflavin (RF) precursor to FMN, and a FMN:adenylyltransfe...