The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and Meci...
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| Published in | Cell Vol. 82; no. 5; pp. 815 - 821 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
08.09.1995
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The D. melanogaster
mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted
mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and Mecip proteins. There is also extensive functional overlap between
mei-41 and ATM. Like ATM-deficient cells,
mei-41 cells are exquisitely sensitive to ionizing radiation and display high levels of mitotic chromosome instability. We also demonstrate that
mei-41 cells, like ATM-deficient cells, fail to show an irradiation-induced delay in the entry into mitosis that is characteristic of normal cells. Thus, the
mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene. |
|---|---|
| AbstractList | The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and Mec1p proteins. There is also extensive functional overlap between mei-41 and ATM. Like ATM-deficient cells, mei-41 cells are exquisitely sensitive to ionizing radiation and display high levels of mitotic chromosome instability. We also demonstrate that mei-41 cells, like ATM-deficient cells, fail to show an irradiation-induced delay in the entry into mitosis that is characteristic of normal cells. Thus, the mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene. The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show that the predicted mei-41 protein is similar in sequence to the ATM (ataxia telangiectasia) protein from humans and to the yeast rad3 and Mecip proteins. There is also extensive functional overlap between mei-41 and ATM. Like ATM-deficient cells, mei-41 cells are exquisitely sensitive to ionizing radiation and display high levels of mitotic chromosome instability. We also demonstrate that mei-41 cells, like ATM-deficient cells, fail to show an irradiation-induced delay in the entry into mitosis that is characteristic of normal cells. Thus, the mei-41 gene of Drosophila may be considered to be a functional homolog of the human ATM gene. |
| Author | Sekelsky, Jeff J McKim, Kim S Boyd, James B Scott Hawley, R Santerre, Anne Hari, Kumar L |
| Author_xml | – sequence: 1 givenname: Kumar L surname: Hari fullname: Hari, Kumar L – sequence: 2 givenname: Anne surname: Santerre fullname: Santerre, Anne – sequence: 3 givenname: Jeff J surname: Sekelsky fullname: Sekelsky, Jeff J – sequence: 4 givenname: Kim S surname: McKim fullname: McKim, Kim S – sequence: 5 givenname: James B surname: Boyd fullname: Boyd, James B – sequence: 6 givenname: R surname: Scott Hawley fullname: Scott Hawley, R |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7671309$$D View this record in MEDLINE/PubMed |
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mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show... The D. melanogaster mei-41 gene is required for DNA repair, mitotic chromosome stability, and normal levels of meiotic recombination in oocytes. Here we show... |
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| SubjectTerms | Animals Ataxia Telangiectasia - genetics Ataxia Telangiectasia Mutated Proteins Cell Cycle - genetics Cell Cycle - radiation effects Cell Cycle Proteins Cloning, Molecular DNA Damage - physiology DNA Damage - radiation effects DNA-Binding Proteins Drosophila melanogaster Drosophila melanogaster - genetics Genes, Insect - genetics Genes, Insect - physiology Humans Molecular Sequence Data Neurons - radiation effects Phenotype Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases - genetics Protein-Serine-Threonine Kinases Proteins - genetics Sequence Homology, Amino Acid Tumor Suppressor Proteins |
| Title | The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene |
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