Efficacy, safety and pharmacokinetics of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control

• Published in: British journal of clinical pharmacology Vol. 85; no. 11; pp. 2547 - 2558
• Main Authors: Wang, Hongyun, Shao, Feng, Liu, Xuemei, Xu, Wen, Ou, Ning, Qin, Xianghong, Liu, Fang, Hou, Xuemei, Hu, Haitang, Jiang, Ji
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.11.2019
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage; 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects; 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacokinetics; Adult; China; Duodenal Ulcer - diagnosis; Duodenal Ulcer - drug therapy; Duodenoscopy; efficacy; Esomeprazole - administration & dosage; Esomeprazole - adverse effects; Esomeprazole - pharmacokinetics; Female; Gastric Acid - metabolism; Gastric Acidity Determination; Healthy Volunteers; Humans; ilaprazole; Infusions, Intravenous; intravenous; Male; Middle Aged; Original; pharmacokinetics; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - pharmacokinetics; proton‐pump inhibitor; Treatment Outcome; Young Adult; China; pharmacokinetics; intravenous; ilaprazole; efficacy; proton-pump inhibitor

Aims The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. Methods Three clinical studies were performed. First,...