Low dose‐eplerenone treatment decreases aortic stiffness in patients with resistant hypertension

• Published in: The journal of clinical hypertension (Greenwich, Conn.) Vol. 19; no. 7; pp. 669 - 676
• Main Authors: Kalizki, Tatjana, Schmidt, Bernhard M.W., Raff, Ulrike, Reinold, Annemarie, Schwarz, Thomas K., Schneider, Markus P., Schmieder, Roland E., Schneider, Andreas
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.07.2017
• Subjects: Aged; aldosterone; aortic stiffness; Arterial Stiffness; Blood Pressure Determination - instrumentation; Carotid Intima-Media Thickness - instrumentation; Coronary Vasospasm - drug therapy; Coronary Vasospasm - physiopathology; Double-Blind Method; Eplerenone; Female; Humans; hypertension; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Mineralocorticoid Receptor Antagonists - administration & dosage; Mineralocorticoid Receptor Antagonists - pharmacology; Original Paper; Prospective Studies; Pulse Wave Analysis - instrumentation; pulse wave velocity; Serum Albumin, Human - urine; Spironolactone - administration & dosage; Spironolactone - analogs & derivatives; Spironolactone - pharmacology; Vascular Stiffness - drug effects; aortic stiffness; pulse wave velocity; hypertension; aldosterone

Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)‐control in patients with treatment resistant hypertension (TRH), but the co...