Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor

• Published in: Angewandte Chemie International Edition Vol. 60; no. 2; pp. 618 - 623
• Main Authors: Guo, Shuwen, Huang, Qiaoxian, Chen, Yuan, Wei, Jianwen, Zheng, Jun, Wang, Leyong, Wang, Yitao, Wang, Ruibing
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 11.01.2021
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; antibiotics; biofilm disruptors; Biofilms - drug effects; Calixarenes - chemistry; Cefazolin - pharmacology; Chemistry; Chemistry, Multidisciplinary; Escherichia coli - physiology; Guanidine - chemistry; guanidinium; host–guest systems; Microscopy, Confocal; Physical Sciences; pillararene; Science & Technology; Staphylococcus aureus - physiology; biofilm disruptors; BACTERIA; guanidinium; host– guest systems; MEMBRANE; antibiotics; pillararene; host-guest systems

Due to the inherent resistance of bacterial biofilms to antibiotics and their serious threat to global public health, novel therapeutic agents and strategies to tackle biofilms are urgently needed. To this end, we designed and synthesized a novel guanidinium‐functionalized pillar[5]arene (GP5) that...