Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker...

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Published inAlzheimer's & dementia Vol. 17; no. 8; pp. 1391 - 1402
Main Authors Disbrow, Elizabeth, Stokes, Karen Y., Ledbetter, Christina, Patterson, James, Kelley, Roger, Pardue, Sibile, Reekes, Tyler, Larmeu, Lana, Batra, Vinita, Yuan, Shuai, Cvek, Urska, Trutschl, Marjan, Kilgore, Phillip, Alexander, J. Steven, Kevil, Christopher G.
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.08.2021
Subjects
ADAS‐cog
brain volume
Cognitive function
FLAIR
H2S
MRI
H2S
FLAIR
Cognitive function
ADAS-cog
MRI
brain volume
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Abstract While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention. Scheme for sulfide dysregulation in ADRD. In ADRD, increased accumulation of sulfides, measured in plasma, may reflect increased formation of H2S metabolites produced in the vascular compartment. Several sulfide species are known to impair blood brain barrier leading to persistent excitotoxic stress and subsequent destructive changes in brain microvascular structure and cognitive function seen in ADRD.
AbstractList While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.
While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H 2 S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H 2 S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H 2 S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H 2 S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H 2 S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H 2 S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention. Scheme for sulfide dysregulation in ADRD. In ADRD, increased accumulation of sulfides, measured in plasma, may reflect increased formation of H 2 S metabolites produced in the vascular compartment. Several sulfide species are known to impair blood brain barrier leading to persistent excitotoxic stress and subsequent destructive changes in brain microvascular structure and cognitive function seen in ADRD.
While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention. Scheme for sulfide dysregulation in ADRD. In ADRD, increased accumulation of sulfides, measured in plasma, may reflect increased formation of H2S metabolites produced in the vascular compartment. Several sulfide species are known to impair blood brain barrier leading to persistent excitotoxic stress and subsequent destructive changes in brain microvascular structure and cognitive function seen in ADRD.
Abstract While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H 2 S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H 2 S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H 2 S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H 2 S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H 2 S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H 2 S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention.
Author Patterson, James
Batra, Vinita
Alexander, J. Steven
Stokes, Karen Y.
Disbrow, Elizabeth
Trutschl, Marjan
Kilgore, Phillip
Pardue, Sibile
Larmeu, Lana
Kelley, Roger
Yuan, Shuai
Ledbetter, Christina
Kevil, Christopher G.
Cvek, Urska
Reekes, Tyler
AuthorAffiliation 10 Department of Pathology and Translational Pathobiology Department of Pathology and Cell Biology and Anatomy LSU Health Shreveport Shreveport Louisiana USA
6 Department of Neurosurgery LSU Health Shreveport Shreveport Louisiana USA
7 Department of Psychiatry and Behavioral Medicine LSU Health Shreveport Shreveport Louisiana USA
1 Department of Neurology LSU Health Shreveport Shreveport Louisiana USA
2 Center for Brain Health LSU Health Shreveport Shreveport Louisiana USA
3 Center for Cardiovascular Diseases and Sciences LSU Health Shreveport Shreveport Louisiana USA
8 Vascular Medicine Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA
9 Dept. of Computer Science Laboratory for Advanced Biomedical Informatics Louisiana State University Shreveport Shreveport Louisiana USA
5 Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport Louisiana USA
4 Department of Pharmacology LSU Health Shreveport Shreveport Louisiana USA
AuthorAffiliation_xml – name: 8 Vascular Medicine Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA
– name: 2 Center for Brain Health LSU Health Shreveport Shreveport Louisiana USA
– name: 3 Center for Cardiovascular Diseases and Sciences LSU Health Shreveport Shreveport Louisiana USA
– name: 1 Department of Neurology LSU Health Shreveport Shreveport Louisiana USA
– name: 4 Department of Pharmacology LSU Health Shreveport Shreveport Louisiana USA
– name: 10 Department of Pathology and Translational Pathobiology Department of Pathology and Cell Biology and Anatomy LSU Health Shreveport Shreveport Louisiana USA
– name: 9 Dept. of Computer Science Laboratory for Advanced Biomedical Informatics Louisiana State University Shreveport Shreveport Louisiana USA
– name: 6 Department of Neurosurgery LSU Health Shreveport Shreveport Louisiana USA
– name: 7 Department of Psychiatry and Behavioral Medicine LSU Health Shreveport Shreveport Louisiana USA
– name: 5 Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport Louisiana USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33710769$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.ejphar.2019.01.072
10.1073/pnas.1005866107
10.3233/JAD-180772
10.1016/j.neuron.2013.10.008
10.1016/j.nlm.2013.05.006
10.1093/jnen/62.12.1287
10.1038/nrn1387
10.1002/ajmg.a.10847
10.15252/emmm.201910695
10.1001/archneur.64.12.1734
10.1161/CIRCULATIONAHA.118.032410
10.1007/3-540-32967-6_7
10.1016/j.neuroimage.2011.11.032
10.1016/S1474-4422(09)70299-6
10.3389/fphar.2017.00686
10.1016/S1474-4422(13)70124-8
10.3389/fnagi.2018.00406
10.1126/science.1566067
10.7555/JBR.27.20120100
10.3233/JAD-131085
10.1179/016164106X130506
10.1016/j.freeradbiomed.2011.01.025
10.1016/S1474-4422(17)30159-X
10.1037/1082-989X.7.4.422
10.1016/j.neuint.2009.12.011
10.1093/cvr/cvv198
10.1016/j.redox.2018.01.007
10.1177/0271678X18803374
10.1038/nrn3114
10.1016/j.redox.2016.08.004
10.1111/j.1749-6632.1994.tb44398.x
10.1371/journal.pone.0117982
10.1016/S1474-4422(11)70072-2
10.3233/JAD-190654
10.1016/j.bbrc.2015.07.115
10.1016/j.jalz.2018.09.008
10.1161/ATVBAHA.118.311402
10.1159/000494113
10.1161/01.STR.0000143317.70478.b3
10.1161/ATVBAHA.120.314084
10.1016/j.jalz.2018.07.222
10.1089/ars.2008.2132
10.1016/j.jns.2012.07.032
10.14336/AD.2019.0226
10.1515/BC.2004.023
10.1007/s12017-018-8505-y
10.1016/j.redox.2020.101567
10.1523/JNEUROSCI.16-03-01066.1996
10.1212/WNL.0000000000006310
10.1016/j.jalz.2018.08.005
10.1016/j.jalz.2019.06.001
10.1016/j.neuint.2013.09.003
10.1111/joim.12192
10.1016/j.freeradbiomed.2012.04.007
10.1186/s12916-014-0206-2
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Keywords H2S
FLAIR
Cognitive function
ADAS-cog
MRI
brain volume
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References 2010; 56
2017; 8
2012; 322
2013; 27
2019; 849
2010; 107
2019; 11
2019; 10
2015; 464
2019; 15
2013; 63
2004; 5
2011; 10
2011; 12
2015; 107
2012; 59
2012; 52
2009; 11
2018; 138
2013; 12
2006; 28
2004; 35
2007; 64
1994; 747
2007; 22
2014; 12
2018; 38
2010; 9
2004; 385
1989; 1
2020; 40
2013; 104
2002; 7
2015; 10
2019; 103
2006
2020; 34
2014; 275
2014; 41
2018; 66
1996; 16
2018; 20
2020; 73
2017; 16
1992; 256
2017; 13
2011; 50
2013; 80
2018; 91
2019
2018
2008; 88
2003; 62
2003; 116A
2018; 10
2016; 9
2018; 15
e_1_2_6_51_1
Liu XQ (e_1_2_6_52_1) 2008; 88
e_1_2_6_53_1
e_1_2_6_32_1
e_1_2_6_30_1
e_1_2_6_19_1
e_1_2_6_13_1
e_1_2_6_36_1
e_1_2_6_11_1
e_1_2_6_34_1
e_1_2_6_17_1
Kelly C (e_1_2_6_58_1) 2019
e_1_2_6_15_1
e_1_2_6_38_1
e_1_2_6_57_1
e_1_2_6_62_1
e_1_2_6_43_1
e_1_2_6_41_1
e_1_2_6_60_1
Alzheimer's Association Calcium Hypothesis W (e_1_2_6_20_1) 2017; 13
e_1_2_6_9_1
e_1_2_6_5_1
e_1_2_6_7_1
Struyfs H (e_1_2_6_56_1) 2014; 41
Kautzky A (e_1_2_6_55_1) 2018; 10
e_1_2_6_24_1
e_1_2_6_49_1
e_1_2_6_3_1
e_1_2_6_22_1
e_1_2_6_28_1
e_1_2_6_45_1
e_1_2_6_26_1
e_1_2_6_47_1
e_1_2_6_54_1
e_1_2_6_10_1
e_1_2_6_31_1
e_1_2_6_50_1
Khachaturian ZS (e_1_2_6_21_1) 1989; 1
e_1_2_6_14_1
e_1_2_6_35_1
e_1_2_6_12_1
e_1_2_6_33_1
e_1_2_6_18_1
e_1_2_6_39_1
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Monllau A (e_1_2_6_59_1) 2007; 22
References_xml – volume: 16
  start-page: 1066
  year: 1996
  end-page: 1071
  article-title: The possible role of hydrogen sulfide as an endogenous neuromodulator
  publication-title: J Neurosci
– volume: 10
  start-page: 406
  year: 2018
  article-title: Prediction of autopsy verified neuropathological change of Alzheimer's disease using machine learning and MRI
  publication-title: Front Aging Neurosci
– volume: 12
  start-page: 723
  year: 2011
  end-page: 738
  article-title: Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
  publication-title: Nat Rev Neurosci
– volume: 27
  start-page: 296
  year: 2013
  end-page: 304
  article-title: Hydrogen sulfide protects against amyloid beta‐peptide induced neuronal injury via attenuating inflammatory responses in a rat model
  publication-title: J Biomed Res
– volume: 56
  start-page: 508
  year: 2010
  end-page: 515
  article-title: Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells
  publication-title: Neurochem Int
– volume: 116A
  start-page: 310
  year: 2003
  end-page: 311
  article-title: Endogenous hydrogen sulfide overproduction in down syndrome
  publication-title: Am J Med Genet A
– volume: 256
  start-page: 184
  year: 1992
  end-page: 185
  article-title: Alzheimer's disease: the amyloid cascade hypothesis
  publication-title: Science
– volume: 747
  start-page: 1
  year: 1994
  end-page: 11
  article-title: Calcium hypothesis of Alzheimer's disease and brain aging
  publication-title: Ann N Y Acad Sci
– volume: 12
  start-page: 822
  year: 2013
  end-page: 838
  article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
  publication-title: Lancet Neurol
– volume: 63
  start-page: 492
  year: 2013
  end-page: 497
  article-title: Physiological role of hydrogen sulfide and polysulfide in the central nervous system
  publication-title: Neurochem Int
– volume: 35
  start-page: 2623
  year: 2004
  end-page: 2627
  article-title: Atherosclerosis of cerebral arteries in Alzheimer's disease
  publication-title: Stroke
– volume: 15
  start-page: 106
  year: 2019
  end-page: 152
  article-title: Alzheimer's disease neuroimaging I: understanding disease progression and improving Alzheimer's disease clinical trials: recent highlights from the Alzheimer's disease neuroimaging initiative
  publication-title: Alzheimers Dement
– volume: 80
  start-page: 844
  year: 2013
  end-page: 866
  article-title: The pathobiology of vascular dementia
  publication-title: Neuron
– volume: 40
  start-page: 874
  year: 2020
  end-page: 884
  article-title: Reactive sulfur species: a new redox player in cardiovascular pathophysiology
  publication-title: Arterioscler Thromb Vasc Biol
– year: 2018
– volume: 464
  start-page: 1254
  year: 2015
  end-page: 1259
  article-title: Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells
  publication-title: Biochem Biophys Res Commun
– volume: 8
  start-page: 686
  year: 2017
  article-title: The role of hydrogen sulfide on cardiovascular homeostasis: an overview with update on immunomodulation
  publication-title: Front Pharmacol
– volume: 52
  start-page: 2276
  year: 2012
  end-page: 2283
  article-title: Analytical measurement of discrete hydrogen sulfide pools in biological specimens
  publication-title: Free Radic Biol Med
– volume: 66
  start-page: 429
  year: 2018
  end-page: 437
  article-title: Tau Protein Dysfunction after Brain Ischemia
  publication-title: J Alzheimers Dis
– volume: 88
  start-page: 2246
  year: 2008
  end-page: 2249
  article-title: Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer's disease and vascular dementia and the significance thereof
  publication-title: Zhonghua Yi Xue Za Zhi
– volume: 22
  start-page: 493
  year: 2007
  end-page: 501
  article-title: Diagnostic value and functional correlations of the ADAS‐Cog scale in Alzheimer's disease: data on NORMACODEM project
  publication-title: Neurologia
– volume: 11
  year: 2019
  article-title: Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology
  publication-title: EMBO Mol Med
– volume: 13
  year: 2017
  article-title: Calcium hypothesis of Alzheimer's disease and brain aging: a framework for integrating new evidence into a comprehensive theory of pathogenesis
  publication-title: Alzheimers Dement
– volume: 10
  year: 2015
  article-title: Role of hydrogen sulfide in early blood‐brain barrier disruption following transient focal cerebral ischemia
  publication-title: PLoS One
– volume: 107
  start-page: 10719
  year: 2010
  end-page: 10724
  article-title: H2S mediates O2 sensing in the carotid body
  publication-title: Proc Natl Acad Sci U S A
– volume: 849
  start-page: 146
  year: 2019
  end-page: 153
  article-title: Role of hydrogen sulfide in cognitive deficits: evidences and mechanisms
  publication-title: Eur J Pharmacol
– volume: 12
  start-page: 206
  year: 2014
  article-title: The overlap between vascular disease and Alzheimer's disease–lessons from pathology
  publication-title: BMC Med
– volume: 10
  start-page: 819
  year: 2011
  end-page: 828
  article-title: The projected effect of risk factor reduction on Alzheimer's disease prevalence
  publication-title: Lancet Neurol
– start-page: 213
  year: 2006
  end-page: 254
  article-title: Nitric oxide and the vascular endothelium
  publication-title: Handb Exp Pharmacol
– volume: 34
  year: 2020
  article-title: The role of nitric oxide in brain disorders: autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders
  publication-title: Redox Biol
– volume: 107
  start-page: 590
  year: 2015
  end-page: 600
  article-title: Cystathionine gamma‐lyase regulates arteriogenesis through NO‐dependent monocyte recruitment
  publication-title: Cardiovasc Res
– volume: 38
  start-page: 2126
  year: 2018
  end-page: 2136
  article-title: Cystathionine gamma‐Lyase modulates flow‐dependent vascular remodeling
  publication-title: Arterioscler Thromb Vasc Biol
– year: 2019
– volume: 5
  start-page: 347
  year: 2004
  end-page: 360
  article-title: Neurovascular regulation in the normal brain and in Alzheimer's disease
  publication-title: Nat Rev Neurosci
– volume: 50
  start-page: 1021
  year: 2011
  end-page: 1031
  article-title: Measurement of plasma hydrogen sulfide in vivo and in vitro
  publication-title: Free Radic Biol Med
– volume: 103
  start-page: 50
  year: 2019
  end-page: 60
  article-title: Mechanisms of hydrogen sulfide against the progression of severe Alzheimer's disease in transgenic mice at different ages
  publication-title: Pharmacology
– volume: 7
  start-page: 422
  year: 2002
  end-page: 445
  article-title: Mediation in experimental and nonexperimental studies: new procedures and recommendations
  publication-title: Psychol Methods
– volume: 15
  start-page: 961
  year: 2019
  end-page: 984
  article-title: Preventing dementia by preventing stroke: the Berlin Manifesto
  publication-title: Alzheimers Dement
– volume: 322
  start-page: 141
  year: 2012
  end-page: 147
  article-title: Does vascular pathology contribute to Alzheimer's changes?
  publication-title: J Neurol Sci
– volume: 10
  start-page: 1282
  year: 2019
  end-page: 1292
  article-title: Physical activity and Alzheimer's disease: a narrative review
  publication-title: Aging Dis
– volume: 62
  start-page: 1287
  year: 2003
  end-page: 1301
  article-title: Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline
  publication-title: J Neuropathol Exp Neurol
– volume: 91
  start-page: e1402
  year: 2018
  end-page: e12
  article-title: An MRI measure of degenerative and cerebrovascular pathology in Alzheimer disease
  publication-title: Neurology
– volume: 275
  start-page: 296
  year: 2014
  end-page: 303
  article-title: Pathways to Alzheimer's disease
  publication-title: J Intern Med
– volume: 104
  start-page: 82
  year: 2013
  end-page: 91
  article-title: Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms
  publication-title: Neurobiol Learn Mem
– volume: 15
  start-page: 418
  year: 2019
  end-page: 428
  article-title: Hypertension and obesity moderate the relationship between beta‐amyloid and cognitive decline in midlife
  publication-title: Alzheimers Dement
– volume: 20
  start-page: 475
  year: 2018
  end-page: 490
  article-title: Neuroprotective effect of hydrogen sulfide in hyperhomocysteinemia is mediated through antioxidant action involving Nrf2
  publication-title: Neuromolecular Med
– volume: 385
  start-page: 285
  year: 2004
  end-page: 289
  article-title: Remodelling of Ca2+ homeostasis in type I cortical astrocytes by hypoxia: evidence for association with Alzheimer's disease
  publication-title: Biol Chem
– volume: 64
  start-page: 1734
  year: 2007
  end-page: 1740
  article-title: Hypertension and the risk of mild cognitive impairment
  publication-title: Arch Neurol
– volume: 59
  start-page: 3774
  year: 2012
  end-page: 3783
  article-title: An automated tool for detection of FLAIR‐hyperintense white‐matter lesions in Multiple Sclerosis
  publication-title: Neuroimage
– volume: 138
  start-page: 1951
  year: 2018
  end-page: 1962
  article-title: Higher aortic stiffness is related to lower cerebral blood flow and preserved cerebrovascular reactivity in older adults
  publication-title: Circulation
– volume: 38
  start-page: 2112
  year: 2018
  end-page: 2128
  article-title: Hypertension, dietary salt and cognitive impairment
  publication-title: J Cereb Blood Flow Metab
– volume: 1
  start-page: 17
  year: 1989
  end-page: 34
  article-title: The role of calcium regulation in brain aging: reexamination of a hypothesis
  publication-title: Aging (Milano)
– volume: 9
  start-page: 119
  year: 2010
  end-page: 128
  article-title: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
  publication-title: Lancet Neurol
– volume: 11
  start-page: 205
  year: 2009
  end-page: 214
  article-title: A source of hydrogen sulfide and a mechanism of its release in the brain
  publication-title: Antioxid Redox Signal
– volume: 41
  start-page: 903
  year: 2014
  end-page: 909
  article-title: Validation of the AD‐CSF‐index in autopsy‐confirmed Alzheimer's disease patients and healthy controls
  publication-title: J Alzheimers Dis
– volume: 16
  start-page: 661
  year: 2017
  end-page: 676
  article-title: Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
  publication-title: Lancet Neurol
– volume: 9
  start-page: 157
  year: 2016
  end-page: 166
  article-title: Hydrogen sulfide metabolism regulates endothelial solute barrier function
  publication-title: Redox Biol
– volume: 73
  start-page: 63
  year: 2020
  end-page: 71
  article-title: Alzheimer's/Vascular spectrum dementia: classification in addition to diagnosis
  publication-title: J Alzheimers Dis
– volume: 28
  start-page: 605
  year: 2006
  end-page: 611
  article-title: Update on hypertension and Alzheimer's disease
  publication-title: Neurol Res
– volume: 15
  start-page: 158
  year: 2019
  end-page: 167
  article-title: Vascular dysfunction‐The disregarded partner of Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 15
  start-page: 480
  year: 2018
  end-page: 489
  article-title: Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease
  publication-title: Redox Biol
– ident: e_1_2_6_62_1
– ident: e_1_2_6_32_1
  doi: 10.1016/j.ejphar.2019.01.072
– ident: e_1_2_6_43_1
  doi: 10.1073/pnas.1005866107
– ident: e_1_2_6_4_1
  doi: 10.3233/JAD-180772
– ident: e_1_2_6_9_1
  doi: 10.1016/j.neuron.2013.10.008
– ident: e_1_2_6_34_1
  doi: 10.1016/j.nlm.2013.05.006
– ident: e_1_2_6_6_1
  doi: 10.1093/jnen/62.12.1287
– ident: e_1_2_6_8_1
  doi: 10.1038/nrn1387
– ident: e_1_2_6_40_1
  doi: 10.1002/ajmg.a.10847
– volume: 13
  start-page: 178‐182 e17
  year: 2017
  ident: e_1_2_6_20_1
  article-title: Calcium hypothesis of Alzheimer's disease and brain aging: a framework for integrating new evidence into a comprehensive theory of pathogenesis
  publication-title: Alzheimers Dement
  contributor:
    fullname: Alzheimer's Association Calcium Hypothesis W
– ident: e_1_2_6_41_1
  doi: 10.15252/emmm.201910695
– ident: e_1_2_6_12_1
  doi: 10.1001/archneur.64.12.1734
– volume: 88
  start-page: 2246
  year: 2008
  ident: e_1_2_6_52_1
  article-title: Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer's disease and vascular dementia and the significance thereof
  publication-title: Zhonghua Yi Xue Za Zhi
  contributor:
    fullname: Liu XQ
– ident: e_1_2_6_15_1
  doi: 10.1161/CIRCULATIONAHA.118.032410
– ident: e_1_2_6_38_1
  doi: 10.1007/3-540-32967-6_7
– ident: e_1_2_6_60_1
  doi: 10.1016/j.neuroimage.2011.11.032
– ident: e_1_2_6_23_1
  doi: 10.1016/S1474-4422(09)70299-6
– ident: e_1_2_6_25_1
  doi: 10.3389/fphar.2017.00686
– ident: e_1_2_6_37_1
  doi: 10.1016/S1474-4422(13)70124-8
– volume: 10
  start-page: 406
  year: 2018
  ident: e_1_2_6_55_1
  article-title: Prediction of autopsy verified neuropathological change of Alzheimer's disease using machine learning and MRI
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2018.00406
  contributor:
    fullname: Kautzky A
– ident: e_1_2_6_3_1
  doi: 10.1126/science.1566067
– ident: e_1_2_6_61_1
– ident: e_1_2_6_36_1
  doi: 10.7555/JBR.27.20120100
– volume: 41
  start-page: 903
  year: 2014
  ident: e_1_2_6_56_1
  article-title: Validation of the AD‐CSF‐index in autopsy‐confirmed Alzheimer's disease patients and healthy controls
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-131085
  contributor:
    fullname: Struyfs H
– ident: e_1_2_6_13_1
  doi: 10.1179/016164106X130506
– ident: e_1_2_6_53_1
  doi: 10.1016/j.freeradbiomed.2011.01.025
– volume: 22
  start-page: 493
  year: 2007
  ident: e_1_2_6_59_1
  article-title: Diagnostic value and functional correlations of the ADAS‐Cog scale in Alzheimer's disease: data on NORMACODEM project
  publication-title: Neurologia
  contributor:
    fullname: Monllau A
– ident: e_1_2_6_50_1
  doi: 10.1016/S1474-4422(17)30159-X
– ident: e_1_2_6_63_1
  doi: 10.1037/1082-989X.7.4.422
– ident: e_1_2_6_26_1
  doi: 10.1016/j.neuint.2009.12.011
– ident: e_1_2_6_42_1
  doi: 10.1093/cvr/cvv198
– ident: e_1_2_6_51_1
  doi: 10.1016/j.redox.2018.01.007
– ident: e_1_2_6_45_1
  doi: 10.1177/0271678X18803374
– ident: e_1_2_6_10_1
  doi: 10.1038/nrn3114
– ident: e_1_2_6_48_1
  doi: 10.1016/j.redox.2016.08.004
– ident: e_1_2_6_22_1
  doi: 10.1111/j.1749-6632.1994.tb44398.x
– ident: e_1_2_6_31_1
  doi: 10.1371/journal.pone.0117982
– ident: e_1_2_6_17_1
  doi: 10.1016/S1474-4422(11)70072-2
– volume-title: Clinical Psychology
  year: 2019
  ident: e_1_2_6_58_1
  contributor:
    fullname: Kelly C
– ident: e_1_2_6_19_1
  doi: 10.3233/JAD-190654
– ident: e_1_2_6_46_1
  doi: 10.1016/j.bbrc.2015.07.115
– ident: e_1_2_6_14_1
  doi: 10.1016/j.jalz.2018.09.008
– ident: e_1_2_6_47_1
  doi: 10.1161/ATVBAHA.118.311402
– ident: e_1_2_6_35_1
  doi: 10.1159/000494113
– ident: e_1_2_6_16_1
  doi: 10.1161/01.STR.0000143317.70478.b3
– ident: e_1_2_6_27_1
  doi: 10.1161/ATVBAHA.120.314084
– ident: e_1_2_6_49_1
  doi: 10.1016/j.jalz.2018.07.222
– volume: 1
  start-page: 17
  year: 1989
  ident: e_1_2_6_21_1
  article-title: The role of calcium regulation in brain aging: reexamination of a hypothesis
  publication-title: Aging (Milano)
  contributor:
    fullname: Khachaturian ZS
– ident: e_1_2_6_28_1
  doi: 10.1089/ars.2008.2132
– ident: e_1_2_6_11_1
  doi: 10.1016/j.jns.2012.07.032
– ident: e_1_2_6_18_1
  doi: 10.14336/AD.2019.0226
– ident: e_1_2_6_44_1
  doi: 10.1515/BC.2004.023
– ident: e_1_2_6_33_1
  doi: 10.1007/s12017-018-8505-y
– ident: e_1_2_6_39_1
  doi: 10.1016/j.redox.2020.101567
– ident: e_1_2_6_29_1
  doi: 10.1523/JNEUROSCI.16-03-01066.1996
– ident: e_1_2_6_57_1
  doi: 10.1212/WNL.0000000000006310
– ident: e_1_2_6_24_1
  doi: 10.1016/j.jalz.2018.08.005
– ident: e_1_2_6_7_1
  doi: 10.1016/j.jalz.2019.06.001
– ident: e_1_2_6_30_1
  doi: 10.1016/j.neuint.2013.09.003
– ident: e_1_2_6_2_1
  doi: 10.1111/joim.12192
– ident: e_1_2_6_54_1
  doi: 10.1016/j.freeradbiomed.2012.04.007
– ident: e_1_2_6_5_1
  doi: 10.1186/s12916-014-0206-2
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Snippet While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and...
Abstract While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's...
While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and...
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wiley
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StartPage 1391
SubjectTerms ADAS‐cog
brain volume
Cognitive function
FLAIR
H2S
MRI
Title Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.12305
https://www.ncbi.nlm.nih.gov/pubmed/33710769
https://search.proquest.com/docview/2501255001
https://pubmed.ncbi.nlm.nih.gov/PMC8451930
Volume 17
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