Proteomic analysis of glutamine-treated human intestinal epithelial HCT-8 cells under basal and inflammatory conditions

• Published in: Proteomics (Weinheim) Vol. 6; no. 13; pp. 3926 - 3937
• Main Authors: Thébault, Sandrine, Deniel, Nicolas, Marion, Rachel, Charlionet, Roland, Tron, François, Cosquer, David, Leprince, Jérôme, Vaudry, Hubert, Ducrotté, Philippe, Déchelotte, Pierre
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.07.2006; WILEY‐VCH Verlag; Wiley-VCH Verlag
• Subjects: Cell Behavior; Cell Line; Cellular Biology; Chemical Sciences; Glutamine; Glutamine - pharmacology; Humans; Inflammation; Inflammation - metabolism; Intestinal cells; Intestinal Mucosa; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Life Sciences; Medicinal Chemistry; Neurobiology; Neurons and Cognition; Pharmaceutical sciences; Pharmacology; Proteolysis; Proteome; Proteome analysis

Glutamine (Gln) promotes intestinal growth and maintains gut structure and function, especially in situations of injury and during inflammation. Several mechanisms could contribute to Gln protective effects on gut. Proteomics enable us to characterize differentially expressed proteins in tissues in...