Pharmacokinetic–pharmacodynamic modelling of neutrophil response to G‐CSF in healthy subjects and patients with chemotherapy‐induced neutropenia - Melhem, Murad; Delor, Isabelle; Pérez‐Ruixo, Juan Jose; Harrold, John; Chow, Andrew; Wu, Liviawati; Jacqmin, Philippe (British journal of clinical pharmacology, 2018)
Keywords: Adrenal Cortex Hormones - adverse effects; Adult; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; cancer; Female; Filgrastim - adverse effects; Filgrastim - pharmacokinetics; Filgrastim - pharmacology; Healthy Volunteers; Hematologic Agents - adverse effects; Hematologic Agents - blood; Hematologic Agents - pharmacokinetics; Hematologic Agents - pharmacology; Humans; Leukocyte Count; Male; modelling and simulation; Models, Biological; Neutropenia - chemically induced; Neutrophils - drug effects; Pharmacokinetic Dynamic Relationships; pharmacokinetic–pharmacodynamic; Polyethylene Glycols - adverse effects; Polyethylene Glycols - pharmacokinetics; Polyethylene Glycols - pharmacology; Randomized Controlled Trials as Topic - statistics & numerical data; cancer; modelling and simulation; pharmacokinetic-pharmacodynamic