Bayesian adaptive designs in single ascending dose trials in healthy volunteers - Guédé, David; Reigner, Bruno; Vandenhende, Francois; Derks, Mike; Beyer, Ulrich; Jordan, Paul; Worth, Eric; Diack, Cheikh; Frey, Nicolas; Peck, Richard (British journal of clinical pharmacology, 2014)
Keywords: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Bayes Theorem; Bayesian adaptive design; Clinical Trials, Phase I as Topic - methods; Clinical Trials, Phase I as Topic - standards; Computer Simulation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Maximum Tolerated Dose; Methods in Clinical Pharmacology Series; safety; Sample Size; single ascending dose trial; single ascending dose trial; safety; Bayesian adaptive design