CircRNA‐0077930 from hyperglycaemia‐stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells

• Published in: Cell biochemistry and function Vol. 38; no. 8; pp. 1056 - 1068
• Main Authors: Wang, Sha, Zhan, Junkun, Lin, Xiao, Wang, Yanjiao, Wang, Yi, Liu, Youshuo
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2020
• Subjects: Aging; Bioinformatics; circRNA; Depletion; Diabetes; Diabetes mellitus; Endothelial cells; Exosomes; high‐glucose; Hyperglycemia; Kidney diseases; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Muscles; Oxidative stress; p53 Protein; Senescence; Smooth muscle; smooth muscle cell; Superoxide dismutase; Umbilical vein; vein endothelial cell exosomes; high-glucose; senescence; smooth muscle cell; circRNA; vein endothelial cell exosomes

Vascular smooth muscle aging leads to diabetic complications such as cardiovascular and kidney diseases or diabetic foot. Therefore, understanding the mechanism of smooth muscle cell senescence in a high‐glucose (HG) environment is essential. The purpose of this study was to determine whether and ho...